<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26963

Description Mediator complex subunit 14
SequenceMAPVQIGSDGQLVPAGGPTSTPQPPPGAPATQGVRLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQAYLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKAEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQVNYIHELVQSRLFGDDKPLQDMYTCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYIPAKCLTLSVWNQQVLGRKTGTASVHKVTIKIDESDGSKPLQISHEPPLPACDSKLMERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKSSNPNDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGVDQSMLDDIEKSINDDMKRIVTWLLQLKFWLGEQRCRQSVKHLPTLCTDTLHLSNLTTHPVGNLSKHRLFIKLTRLPQYYIVVEMFDVPSNLTELQYKYYFLSVSQMESEDGLPSAQLFRHFKPNLEELVQDISSCRMVRPGTKRKLSGEQSAVEPKKPKRSGEMCAFNKELAHLVAMCDTNMPLIGLRSELSNMEIPHQGVQVEGDGCSHAIRILKVPPCMAVGEETRKALERSLLDCTFRLQGRNNRTWVAELIFSSCPLNSTSIKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWNSISKLYECVLEFSRSLTEMPSYLSLFSEIRLYNYRKLVLCYGSTKGSSVTIQWNSVTHRYHLALGTVGPNSGCSNCHNIILHQLQEMFNKTPNVVQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPISMEDTFMPHTQTQPPGRGVYPPLTSPPNPYHVPPSPSMITTQSPGNIHAANSPSGALRAPSPFGPTPSPSSLGISMGQTSNFASPHGTLDPSSPYTLVSASPRVGPWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPSHSPRAGTSSQAMPPPRKLPQRSWAASIPTILTHSKLHVLLLPSPMPCPVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQLEPNLTIVNSNEPGVIMFKTEVLKCRVALNPKSYQTLQLKVTPENTGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAAQLNWNVQFCLTIPPSAPPIAPPGTIAVVLKTKMLFFLQLTQRLPVPQEPISIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSSILRRFNEHHPPRPGECTIFAAVHELMANLTLNSGGRP
Length1421
PositionTail
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio.
Aromaticity0.07
Grand average of hydropathy-0.185
Instability index51.74
Isoelectric point8.69
Molecular weight158147.10
Publications
PubMed=23594743

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
blood vessel morphogenesis	GO:0048514	IMZFIN
brain development	GO:0007420	IMZFIN
embryonic viscerocranium morphogenesis	GO:0048703	IMZFIN
neural crest cell differentiation	GO:0014033	IMZFIN
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
stem cell population maintenance	GO:0019827	IMZFIN
ventricular system development	GO:0021591	IMZFIN









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26963
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     353.70|     111|     209|     536|     652|       1
---------------------------------------------------------------------------
  536-  652 (174.94/145.89)	VVEMF....DVPSNLTELQYKYYfLSVSQMESEDGLPS.AQLFRHFKPNLEELVQDISSCRMVRPGTKRKLsgeQSAVEPKKPKrSG.EMCaFNKELAHLVAMCDTNMPLIGLRSELSNMEIP
  747-  863 (178.76/126.38)	VVEMFlndwNSISKLYECVLEFS.RSLTEMPSYLSLFSeIRLYNYRKLVLCYGSTKGSSVTIQWNSVTHRY...HLALGTVGPN.SGcSNC.HNIILHQLQEMFNKTPNVVQLLQVLSDTQAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     196.73|      30|      30|     981|    1010|       2
---------------------------------------------------------------------------
  981- 1006 (47.21/17.58)	..................PHT..QTQPPGRGVYPPLTSP......PNP.YHVP
 1007- 1039 (33.89/10.47)	PSPS.................miTTQSPG.NIHAA.NSPsgalraPSP.FGPT
 1040- 1081 (39.23/13.33)	PSPSslgismgqtsnfasPHG..TLDP..SSPYTLVSAS......PRV.GPWP
 1082- 1108 (40.62/14.07)	GSP....................QVSGPSPGARIPGMSP......GNPsLHSP
 1138- 1163 (35.77/11.48)	AS...............iPTI..LTHSK...LHVLLLPS......PMP.CPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     187.54|      34|      34|     260|     293|       3
---------------------------------------------------------------------------
  232-  256 (26.05/11.78)	........LLKLEIL.VEDKE.TGDGRALVH....SMQV
  257-  290 (55.19/33.57)	NYIHE...LVQSRLF.GDDKP.LQDMYTCLHSFCLSLQL
  291-  324 (42.67/24.20)	EVLHSqtlMLIRERW.GD....LVQVERYIPAKCLTLSV
  442-  472 (29.88/14.65)	D.LHS..gMFQPMLY.GVDQSmLDDIEKSIND...DMK.
  473-  501 (33.75/17.54)	RIVTW...LLQLKFWlGEQRC.RQSV.KHLPTLC.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.21|      18|      28|     147|     166|       4
---------------------------------------------------------------------------
  147-  166 (29.48/21.02)	TTgsYPRLPTCIRDKII....PPD
  175-  196 (25.72/11.74)	TT..LNQLNQILRHRLVttdlPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.75|      13|      15|    1247|    1261|       7
---------------------------------------------------------------------------
 1247- 1261 (19.48/13.89)	QVLEKFfeTRVAGPP
 1265- 1277 (20.28/ 8.34)	NTLNAF..TKLLGAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.51|      13|      31|      70|      82|       8
---------------------------------------------------------------------------
   70-   82 (22.05/14.73)	IVQFASRTRQLFV
  103-  115 (22.46/15.16)	ISSFLDQQAYLFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.08|      13|      19|     888|     900|      11
---------------------------------------------------------------------------
  888-  900 (26.03/13.46)	CFSILPQSPT..HIR
  908-  922 (19.05/ 7.83)	CIDIYCRSRGvvAIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.53|      29|    1288|      19|      47|      13
---------------------------------------------------------------------------
   19-   47 (53.20/31.53)	TSTPQPPPGA.PATQGVRLSLLIEFLLQRT
 1309- 1338 (48.34/27.87)	TIPPSAPPIApPGTIAVVLKTKMLFFLQLT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26963 with Med14 domain of Kingdom Metazoa
Unable to open file!