<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26961

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMDPTSKSGLNQVSDVVFVIEGTANLGPYFESLRNNYILPTIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTADSLVQIIRDRGIHFSVIAPRKLPALRSLFERASSVAGPPESSHPDYSQDPFHMVLVRGIALPVAPGGGSVPVSLKPVLPPQSLPVNQNPLVPVASTAPQMNTFQNVSLHAAHDAAQKALEEAANQQQKNRFGQISTPPFSQSPVLPPGGKPSLSTVTTVSPPVLTQQQVPPQQPQQQTQVPQPGLPAVNQQPPQASQQQPNNQQTPPPTQPGMAAVPAPPPGAQQGVANKVVAWSGVLEWQEKPKASSMDSNTKLTRSLPCQVQVSQGENLNTDQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFLFTNKDMESLKGLFRIMTSGFAGCVHFPHSAPCEVRVLMLLYSSRKRIFMGLIPNDQSGFVNGIRQVITNHKQVQQQRSMQPGQVQPNQNFLNRPPGPIPVTHGNVPQQLRAAATGNQQAPVTGAPPNQVQGQAQAPGGGMLRLQNPGANPQLRSLLLSQQPQGGMQGMQGMHPIQQMVHAAPGGGAQMQPQWRQPHQGPLMVPTGPRGPVTQNPGMPSVSSVMEDEILMDLI
Length701
PositionUnknown
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio.
Aromaticity0.06
Grand average of hydropathy-0.316
Instability index54.08
Isoelectric point8.05
Molecular weight75446.12
Publications
PubMed=23594743

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26961
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     447.79|      66|      66|     239|     304|       1
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   71-  152 (59.03/15.46)	.......VDC..APES...YVQ....................CHAPTS.SAF...EFVS........W...IDSIQfmgggaescsliaeglsvalqlfddfKKMR....EQI..GQ............THKVCVLLC.NSPP......YLL...........................P..A
  153-  240 (43.72/ 9.78)	VESVSYT..............G....................CTADSLvQII...RDRG........IHFSVIAPR..........................KL.......PA..LR............SLFERASSV.AGPPesshpdYSQdpfhmvlvrgialpvapgggsvpvslkP..V
  241-  307 (104.46/32.35)	LPPQSLPVNQ..NPLV...PVA....................STAPQM.NTF...QNVS........LHAAHDAAQ..........................KALE....EAA..NQ............QQKNRFGQI.STPP......FSQ..........................sP..V
  308-  356 (71.77/20.20)	LPPGGKP......SLS...TVT....................TVSPPV.LTQ...QQVP...................................................PQQ..PQ............QQ.TQVPQP.GLPA......VNQ..........................qP..P
  357-  418 (69.94/19.52)	QASQQQPNNQ..QTPP...P.......................TQPGM.AAV...PAPP........PGAQQGVAN..........................KVVA....WSGvlEW............QEKPKASSMdSNTK......L.................................
  420-  460 (49.09/11.77)	...RSLPCQ......V...QV.....................SQGENL.NTD...Q.................WPQ..........................KLIM....QLI..PQ............QLLTTLG.....PL......F.................................
  549-  662 (49.77/12.02)	QPGQVQPNQNflNRPPgpiPVThgnvpqqlraaatgnqqapvTGAPPN.QVQgqaQAPGggmlrlqnPGAN...PQ............................LRslllSQQ..PQggmqgmqgmhpiQQMVHAA.P.GGGA......QMQ...........................PqwR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26961 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HKQVQQQRSMQPGQVQPNQNFLNRPPGPIPVTHGNVPQQLRAAATGNQQAPVTGAPPNQVQGQAQAPGGGMLRLQNPGANPQLRSLLLSQQPQGGMQGMQGMHPIQQMVHAAPGGGAQMQPQWRQPHQGPLMVPTGPRGPVTQNPGMPSVSSVME
2) LPVNQNPLVPVASTAPQMNTFQNVSLHAAHDAAQKALEEAANQQQKNRFGQISTPPFSQSPVLPPGGKPSLSTVTTVSPPVLTQQQVPPQQPQQQTQVPQPGLPAVNQQPPQASQQQPNNQQTPPPTQPGMAAVPAPPPGAQQGVA
539
246
693
391










Molecular Recognition Features






MoRF SequenceStartStop




NANANA