<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26955

Description Cyclin-dependent kinase 19
SequenceMDYDFKTKLAAERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFLEDPLPTSDVFAGCQIPYPKREFLSEDEPEEKAEKNQTQQHQQTAAQTQTQTQQAPTQQSSAQTNGTSGTAGANTGPSMQHGQDQGPPNKKTRTSGTGVHQTDYQHSSSRLGYQSNIQGSTQSQSTMGYSSSSQHSHQSHRY
Length477
PositionKinase
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio.
Aromaticity0.09
Grand average of hydropathy-0.728
Instability index44.44
Isoelectric point8.66
Molecular weight54541.06
Publications
PubMed=23594743

Function

Annotated function 
GO - Cellular Component
cytosol	GO:0005829	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central

GO - Biological Process
protein phosphorylation	GO:0006468	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26955
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.22|      14|      14|     377|     390|       1
---------------------------------------------------------------------------
  377-  390 (24.15/14.99)	QQTAAQTQTQTQQA
  393-  406 (24.07/14.93)	QQSSAQTNGTSGTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.27|      25|      40|     102|     129|       2
---------------------------------------------------------------------------
  102-  129 (44.55/37.49)	HDLWhiiKFHRASK.ANKKPM.QLP.RGMVK
  143-  170 (34.73/21.08)	HANW...VLHRDLKpANILVMgEGPeRGRVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.43|      20|      39|     417|     436|       5
---------------------------------------------------------------------------
  417-  453 (25.33/12.89)	GQDQGPPNKKTRTSGTGVHqtdyqhsssrlgyqsniQ
  454-  473 (35.09/20.53)	GSTQSQSTMGYSSSSQHSH.................Q
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26955 with CDK8 domain of Kingdom Metazoa
Unable to open file!