<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26953

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVPGPDSDWRSPAFRQKVVAQIEEAMRKAGTGHTKSSTEMESHVFTKAKTREEYLSMVARLIIHFRDIHKKAQGGPDPINALQNLPGGVPGVIGPRPPGAQMGGMGQMSMGPHAMQGVAGGQQGAGAAGPMQQMIQQQQQQQQQQQQQSIQFQTFQPQQQQQATMQSQQPSAMFQQIRLQQLQQHHQNQQMQHQNQQQQQAQNQQQQNQLHQTRMQQQLQLQQLQQQQQQQQQLHQQQVHAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQSIQQMQQQQQLQVQAQGQPQVQGQGGAVQMPPHSQQQQVLVPQMVQGQHSQMSALSQQQQLKLQQAMQARMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQVQQVQQASQLTAVPGQMMPRPGMQIPPRLPRATPNSAIPQNPVAIGGQQMPQAQQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSGPTPSPGGFQPSPSPQPSQSPASSRTPQSYPLQVPSPGPLNTPGNPSSVMSPAGASQSEDQLYMDKLRQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPNTRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPCTKKQYLCQPILDAVLANIRSPVFNHSLYRTFAPAMTAIHGPQITGPSIPSRKRKLEDDERQTIPNILQGEVARLNSKFLVNLDPSFCSNNGMVHLICKLDDKNLPSVPPLQLSIPADYPDQSPHWEDDGQQYEANPFLQTVHKNMTSKLLQLPDKHSVTALLNTWAQSVRQACLSA
Length802
PositionTail
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio.
Aromaticity0.03
Grand average of hydropathy-0.954
Instability index83.39
Isoelectric point9.58
Molecular weight89138.28
Publications
PubMed=23594743

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26953
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.69|      15|      15|     355|     369|       1
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  355-  369 (35.84/ 6.28)	QQQQQQQQQQQQQQQ
  371-  385 (35.84/ 6.28)	QQQQQQQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.39|      21|      21|     192|     212|       3
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  132-  152 (39.79/ 6.94)	MQQMIQQQQQQQQQQQQQSIQ
  192-  212 (42.24/ 7.98)	MQHQNQQQQQAQNQQQQNQLH
  216-  236 (39.36/ 6.75)	MQQQLQLQQLQQQQQQQQQLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.49|      29|      30|     464|     493|       4
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  286-  317 (44.69/ 8.25)	Q.QMQQQQQLQVQAQGQPQ.VQGQggaVQMPPHS
  462-  492 (45.80/10.87)	MpPPPQPQPSPQPPSSQPNsVSSG...PTPSPGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.29|      20|      23|     403|     423|       7
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  403-  419 (25.01/ 9.72)	....AvPGQMMPRPGMQIPPR
  510-  528 (34.04/11.71)	TPQSY.PLQ.VPSPGPLNTPG
  529-  545 (25.24/ 6.48)	NPSSV....MSPAGASQSEDQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.71|      38|     125|     603|     646|      11
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  603-  646 (66.86/37.27)	CEIaleklkNDMAVPTPPP.............PPVPCTKKQYLCQPILDAVLANIRS
  723-  773 (64.85/27.82)	CKL......DDKNLPSVPPlqlsipadypdqsPHWEDDGQQYEANPFLQTVHKNMTS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26953 with Med15 domain of Kingdom Metazoa
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