<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26953
Description |
Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MDVPGPDSDWRSPAFRQKVVAQIEEAMRKAGTGHTKSSTEMESHVFTKAKTREEYLSMVARLIIHFRDIHKKAQGGPDPINALQNLPGGVPGVIGPRPPGAQMGGMGQMSMGPHAMQGVAGGQQGAGAAGPMQQMIQQQQQQQQQQQQQSIQFQTFQPQQQQQATMQSQQPSAMFQQIRLQQLQQHHQNQQMQHQNQQQQQAQNQQQQNQLHQTRMQQQLQLQQLQQQQQQQQQLHQQQVHAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQSIQQMQQQQQLQVQAQGQPQVQGQGGAVQMPPHSQQQQVLVPQMVQGQHSQMSALSQQQQLKLQQAMQARMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQVQQVQQASQLTAVPGQMMPRPGMQIPPRLPRATPNSAIPQNPVAIGGQQMPQAQQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSGPTPSPGGFQPSPSPQPSQSPASSRTPQSYPLQVPSPGPLNTPGNPSSVMSPAGASQSEDQLYMDKLRQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPNTRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPCTKKQYLCQPILDAVLANIRSPVFNHSLYRTFAPAMTAIHGPQITGPSIPSRKRKLEDDERQTIPNILQGEVARLNSKFLVNLDPSFCSNNGMVHLICKLDDKNLPSVPPLQLSIPADYPDQSPHWEDDGQQYEANPFLQTVHKNMTSKLLQLPDKHSVTALLNTWAQSVRQACLSA |
Length | 802 |
Position | Tail |
Organism | Danio rerio (Zebrafish) (Brachydanio rerio) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes>
Danionidae> Danioninae> Danio.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.954 |
Instability index | 83.39 |
Isoelectric point | 9.58 |
Molecular weight | 89138.28 |
Publications | PubMed=23594743
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148
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GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
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GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP26953
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 71.69| 15| 15| 355| 369| 1
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355- 369 (35.84/ 6.28) QQQQQQQQQQQQQQQ
371- 385 (35.84/ 6.28) QQQQQQQQQQQQQQQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 121.39| 21| 21| 192| 212| 3
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132- 152 (39.79/ 6.94) MQQMIQQQQQQQQQQQQQSIQ
192- 212 (42.24/ 7.98) MQHQNQQQQQAQNQQQQNQLH
216- 236 (39.36/ 6.75) MQQQLQLQQLQQQQQQQQQLH
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 90.49| 29| 30| 464| 493| 4
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286- 317 (44.69/ 8.25) Q.QMQQQQQLQVQAQGQPQ.VQGQggaVQMPPHS
462- 492 (45.80/10.87) MpPPPQPQPSPQPPSSQPNsVSSG...PTPSPGG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 84.29| 20| 23| 403| 423| 7
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403- 419 (25.01/ 9.72) ....AvPGQMMPRPGMQIPPR
510- 528 (34.04/11.71) TPQSY.PLQ.VPSPGPLNTPG
529- 545 (25.24/ 6.48) NPSSV....MSPAGASQSEDQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 131.71| 38| 125| 603| 646| 11
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603- 646 (66.86/37.27) CEIaleklkNDMAVPTPPP.............PPVPCTKKQYLCQPILDAVLANIRS
723- 773 (64.85/27.82) CKL......DDKNLPSVPPlqlsipadypdqsPHWEDDGQQYEANPFLQTVHKNMTS
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