<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26949

Description Uncharacterized protein
SequenceMSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQQASAAAAAAAAAAATAAPAAPAAVAQQHPPKNGEAAVNGEENGAHAINNHSKPMEIDGDVEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNKKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDTCVHDLQAHSKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDVERGVCIHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGSLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
Length526
PositionTail
OrganismCanis lupus familiaris (Dog) (Canis familiaris)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Canidae> Canis.
Aromaticity0.07
Grand average of hydropathy-0.268
Instability index38.94
Isoelectric point5.46
Molecular weight56728.64
Publications
PubMed=16341006

Function

Annotated function 
GO - Cellular Component
histone deacetylase complex	GO:0000118	IBA:GO_Central

GO - Biological Function
transcription corepressor activity	GO:0003714	IBA:GO_Central

GO - Biological Process
histone deacetylation	GO:0016575	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26949
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     371.23|      40|      40|     334|     373|       1
---------------------------------------------------------------------------
  177-  206 (34.18/17.35)	..............LRGHESE...........VFICAWNPVS.........dlL.ASGS.GDSTAR
  225-  262 (42.91/23.73)	HCirEGGHDVP..S....NKD...........VTSLDWNSDG.........tlL.ATGS.YDGFAR
  263-  292 (31.31/15.25)	I...WTEDGNLASTLGQHKGP...........IFALKWNKKG..........nY............
  293-  344 (44.81/25.12)	IL..SAGVDKTTIIWDAHTGEakqqfpfhsapALDVDWQNNT..........tF.ASCS.TDMCIH
  345-  386 (62.80/38.28)	VC..RLGCDRPVKTFQGHTNE...........VNAIKWDPSG.........mlL.ASCS.DDMTLK
  387-  437 (58.69/35.27)	IW..SMKQDTCVHDLQAHSKE...........IYTIKWSPTGpatsnpnsnimL.ASAS.FDSTVR
  441-  479 (50.47/29.26)	VE..RGVC...IHTLTKHQEP...........VYSVAFSPDG..........kYlASGS.FDKCVH
  480-  521 (46.07/26.04)	IW..NTQSGSLVHSYRG.TGG...........IFEVCWNARG........dkvG.ASASdGSVCV.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.70|      22|      27|      94|     115|       2
---------------------------------------------------------------------------
   94-  115 (34.93/23.85)	TRQQAFREKLAQQQQASAAAAA
  122-  143 (37.77/26.41)	TAAPAAPAAVAQQHPPKNGEAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.55|      24|      28|      30|      54|       3
---------------------------------------------------------------------------
   30-   54 (35.75/25.32)	IESHISqSNINGTLVP..PAALISILQ
   60-   85 (34.80/19.94)	VEAEIS.INEDGTVFDgrPIESLSLID
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26949 with Med16 domain of Kingdom Metazoa
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