<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26948

Description Mediator of RNA polymerase II transcription subunit 13
SequenceSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEEELGYDDDFPVAVEVIVGGVRLVYPSAFVLISQNDIPVPQSVAGAGGHITVGQQGLGSGKDPSNCGMPLTPPTSPEQAVIGESGGTQSAVSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRAQSKRSQMSTPTLEEEPANNPATWDFVDPTQRVSCSCSRERCWHKLLKRCAVGPNRPPAISQPGFSAGPSSSSSLPPPASKHKTTERPEKGDKLQKRPLIPFHHRPSVADEFCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGVRPSNPESSDKWWHSYRLPPIDDAEFRPPELQGDRCDAKMEVNSESTALQRLLAQPNKRFKIWQEKQPQMQPLHFLDPLPLSQQPGDSLGEINDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGAEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEVKDFSYVHKVPTFQPLVGSSMFAPLKMLPSQCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAAIFNRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTFLPQMEGARKSQEPPISLLLLLQNQHTQPFASLSFLDYISSNSRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQSPPAAAPGQATPGNAGPLASNAGSTVSSAGSAFNPTSSSSSGNPAASSSASGSSVPPVSSSAPAPVINQISTTSSSGFSASVVGQNPGTGASSADRTQGNLGCVGDPEPGQSSSQSLQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTADEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPVKDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2057
PositionMiddle
OrganismCanis lupus familiaris (Dog) (Canis familiaris)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Canidae> Canis.
Aromaticity0.07
Grand average of hydropathy-0.387
Instability index60.12
Isoelectric point5.62
Molecular weight225081.98
Publications
PubMed=16341006

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26948
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     492.95|     127|     141|     330|     470|       1
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  286-  399 (156.58/88.42)	PPAIS.QPgfsAGpSSSSSLPPPAskhkTTERPE.KGDKLQKRPL.....................ipFHHRPSVA.DEFCMEQ.DT..................................PGQKLGLAGIDSSLEV.SS.S.RKYD.KQMAVPSR......................................NTSKQMNLNPMDSP....HSPISPL
  400-  543 (156.40/105.91)	PPTLSPQP...RG.QETESLDPPS....VPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVS.....................etalycgvrpsnpessdkwwhsyrlppiddaefrPPELQG.DRCDAKMEV.NSeS.TALQ.RLLAQPNK......................................RFKIWQEKQPQMQP....LHFLDPL
  544-  698 (131.86/71.42)	P..LSQQP....G....DSLGEIN.......DPYTFEDG.DIKYIFTANKKCKQGTEKDSLKKNKS..........eDGFGTKDvTT..................................PGHSTPVPDGKNAMSIfSS.A.TKTDvRQDNAAGRagsssltqvtdlapslhdldnifdnsdddelgavspalRSSKMPAVGAEDRPlgkdGRAAVPY
 1373- 1429 (48.12/16.66)	....................................................................YQSPPAAA.P....GQ.AT..................................PGNAGPLAS..NAGSTvSS.AgSAFN......PTS......................................SSS...SGNPAASS....SASGSSV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.72|      26|      26|     878|     903|       2
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  878-  903 (47.54/21.51)	GAGVLPSPATPRFSVPTPRTP.RTPRT
  906-  932 (41.17/17.61)	GGGTASGQGSVKYDSTDQGSPaSTPST
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.54|      20|      20|     810|     829|       3
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  810-  829 (38.88/20.75)	IPDACLF.RPSWAIPPKIEQL
  831-  851 (32.65/16.21)	MPPAAIFnRDGYNNVPSVGSL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.36|      17|      21|    1457|    1474|       4
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 1457- 1474 (27.42/17.24)	VGqNPGTGASSADRTQ.GN
 1478- 1495 (27.94/12.91)	VG.DPEPGQSSSQSLQdGQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.48|      20|      24|    1220|    1242|       5
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 1223- 1242 (37.03/24.90)	PLPI.PTLLV...GYDKD..FLTISP
 1244- 1269 (23.45/ 6.08)	SLPFwERLLLdpyGGHRDvaYIVVCP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.11|      26|      26|    1797|    1822|       6
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 1797- 1822 (45.92/30.35)	AMEPQGSFVVMPVKDAVTMGSVFGRS
 1824- 1849 (46.20/30.59)	ALNMQSSQLNTPQDASCTHILVFPTS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.15|      26|    1269|       4|      30|       7
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    4-   30 (45.39/30.30)	LSCAFTFFlHGESNVCTSVEIAQHQPI
 1275- 1300 (48.77/28.45)	LEGAKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.35|      18|      27|    1711|    1737|       8
---------------------------------------------------------------------------
 1711- 1729 (30.47/32.85)	RSkVSAR..KIGLQKLWEWCI
 1740- 1759 (27.88/ 9.70)	RV.VIGRlgRLGHGELKDWSI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.31|      17|      17|    1077|    1093|       9
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 1070- 1086 (28.94/15.80)	LLLLQNQHTQ..PFASLSF
 1087- 1105 (27.38/14.50)	LDYISSNSRQtlPCVSWSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.49|      21|      27|    2003|    2023|      10
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 2003- 2023 (37.12/27.28)	PLDSKTTSDV.LRF.VLEQ.YNAL
 2030- 2053 (26.37/16.89)	PATQDRTSCLpVHFvVLTQlYNAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.04|      23|      26|    1585|    1610|      12
---------------------------------------------------------------------------
 1588- 1610 (44.77/37.28)	YIQYLKSM..AFSVYCQCR...RPLPTQ
 1612- 1639 (30.27/14.04)	HIKSLTGFgpAASIEMTLKnpeRPSPIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.79|      20|      22|    1877|    1896|      13
---------------------------------------------------------------------------
 1856- 1871 (23.77/ 7.87)	..PANYPNEDG..FSPNN.DD
 1877- 1896 (36.86/16.20)	PFPDDMDNDIGILMTGNL.HS
 1902- 1921 (30.16/11.94)	PVPSP.GSPSGIGVGSHFqHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.86|      19|      20|    1542|    1561|      15
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 1542- 1561 (31.05/20.98)	NFWLLSLMRCyTEMLDNLPE
 1565- 1583 (34.81/18.63)	NSFILQIVPC.QYMLQTMKD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.57|      46|     640|    1304|    1354|      16
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 1304- 1354 (68.17/51.21)	LRDGIMRVGKTVAQKLTDELvSEWFnqpWSS.EENDNHSRLKLYAQVcRHHL
 1937- 1983 (81.40/43.79)	LKQQPLALGYFVSTAKAENL.PQWF...WSScPQAQNQCPLFLKASL.HHHI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.85|      14|      25|     978|     992|      20
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  978-  992 (23.67/18.64)	CACNMN.IKGADVGlY
 1004- 1018 (24.17/13.88)	CTCGFSaIMNRKLG.Y
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26948 with Med13 domain of Kingdom Metazoa
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