<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26939

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISSCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSSHCSASCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFSSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLSEEEIPDKVASWDFVEATQRTNCSCLRHKSLKPRNPGQQGQAPSLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPAQFQEAVEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAIASDAEQESKIDPYAFVEGDEEFLFPDKKDRQNSEREAVKKHKVEDGPSSVTVLSHEEDAMSLFSPSIKQDAPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGTDDKSSSKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMSNKEYGSMDITPGGTVLEGNSSSIGTQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKSLPSQCLPPIKLPEECIYRQSWTVGKLELLPSGPAVPFIKEGDGSTIDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPMQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTECGKEAEKRFEALRATSAEHVNGGLKESEKFPDELILLLQDQCTNLFSPFGAADQDPFPRIGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLFLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVAPASQSLITSPQMTNTGNANTPSATLASAASSTITVTSGVAMSSSVATANSTLTTTSTSSSSSSNLNSGVSSNKLPSFPPFGSMNSSATGSMSTQGNTVQNGQLGGQQSSALQTAGISGESSSLPAQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSSLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2042
PositionMiddle
OrganismCanis lupus familiaris (Dog) (Canis familiaris)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Canidae> Canis.
Aromaticity0.07
Grand average of hydropathy-0.406
Instability index52.95
Isoelectric point5.45
Molecular weight224225.21
Publications
PubMed=16341006

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleoplasm	GO:0005654	IEA:Ensembl
GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
triglyceride homeostasis	GO:0070328	IEA:Ensembl

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26939
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1050.11|     237|     327|     273|     533|       1
---------------------------------------------------------------------------
   49-  251 (216.44/92.77)	......................................................................INQ.HQPVYllsEEHITL.AQQ..SNSPFQVILSPFGLNGTLTGQAF.KMSDSATKKLIGEwkqfYPISSClkEMSEEKQED.........MDwEDDSLAAVEvlVAG.VRMIYP....ACFVlVPQSDIPTPSSVGSSHCSASCLG.VHQVPAST.............RDPAMSSVT.LTPPTSP..E..EvqTVDP..........QSaqkWVK....fSSVSDGF....SSDSTSHHGGKIPRK......LANHVVDRVWQE
  273-  509 (417.03/222.29)	EE..IPDKVASWD.FVEATQR.......TNCSCLRHK.........S..LK...PRN....PGQQGQAPSLSQ.QQQVL...PKHKTN.EKQEKSEKPQKRPLTPFHHRVSVSDDVG.MDTDSASQRLVIS....APDSQV..RFSNIRTND.........VA.KTPQMHGTE..MAN.SPQPPPLSPHPCDV.VDEGVTKTPSTPQSQHFYQMPTP.DPLVPSKP.............MEDRIDSLS.QSFPAQF..Q..E..AVEP..........TV...YVG.....TAVNLEE....DEANIAWKYYKVPKKKDV.EFLPPQLPSDKFKD
  574-  767 (217.21/93.16)	EEflFPDKKDRQNsEREAVKKhkvedgpSSVTVLSHEedamslfspS..IKqdaPR.....PTSHARPPSTSLiYDSDL...AVSYTDlDNLFNSDEDE...LTPGSKK.SAN...G.TDDKSSSKESKTG....NLDP.....LSCISTAD.......................LHKmYPTPPSLEQH......................................................IMGFS....PMNMsnK..E..YGSM..........DI...TPG.....GTV.LEG....NSSSIGTQ.FKI..EVDE.GFCSPK.PSE.IKD
  768-  989 (199.42/86.30)	....................................F.........SyvYK...PENcqvlVGCSMFAPLKSL.PSQCL...P..............PIKLPEECIYRQ...SWTVGkLE.......LLPS....GP..AV..PF..IKEGDgstidqeygPA.YTPQTH.......T.SFGMPPSSAPPSN..SGAGILPSPSTP......RFPTPrTPRTPRTPraggpasaqgsvkYENS.DLYSpASTPSTC..RplN..SVEPatvpsipeahSL...YVNlilseSVMNLFKdcnfDSCCICVCNMNI.KGADVgVYIPDPMQEAQYR.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.44|      46|     533|    1128|    1178|       2
---------------------------------------------------------------------------
 1128- 1178 (81.35/72.94)	CL...HPWskrndVSMQCSQ...DILRMLLFLQPVLQDAIQKKRTVRPWGVQGPLTW
 1663- 1714 (74.09/53.99)	CLshdQRW.....ILASCTDlygELLETCIINIDVPNRARRKKGSARRFGLQKLWEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     340.55|      83|     328|    1485|    1567|       3
---------------------------------------------------------------------------
 1485- 1567 (143.78/92.59)	MDRDKVGIPTDGD..SHAITYPPAIVVYIID.PFTYENKDESTN.SSNVWTLGL.LRCFLEMVQT..LPPHIKSTVSVQIVPCQYLLQPV
 1812- 1892 (111.46/69.75)	MQTSQLNTPQDT.scTHILVFPTSASVQVASaTYTTENLDLAFN.PNNDGADGMgIFDLLDTGDD..LDPDI.....INILPASPTGSPV
 1900- 1965 (85.31/51.28)	........PHGGD..AGKGQGTDRL........LSTESHDEVTNiLQQPLALGY....FVSTAKAgpLPDWFWSACPQAQYQCPLFLK..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.51|      11|      20|    1190|    1200|       5
---------------------------------------------------------------------------
 1190- 1200 (22.98/12.80)	YGTD...ESPEPLP
 1208- 1221 (17.52/ 7.66)	YDYDflvLSPFALP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.09|      24|      27|    1345|    1368|       6
---------------------------------------------------------------------------
 1345- 1368 (42.97/25.89)	PN..LVAPASQSL.ITSP.QMTNT.GNAN
 1370- 1398 (21.12/ 8.58)	PSatLASAASSTItVTSGvAMSSSvATAN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26939 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CSCLRHKSLKPRNPGQQGQAPSLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFP
2) DLDNLFNSDEDELTPGSKKSANGTDDKSSSKESKTGNLDP
3) FPDKKDRQNSEREAVKKHKVEDGPSSVTVLSHEE
4) GSPVHSPGSHYPHGGDAGKGQGTDRLLSTESH
5) SVATANSTLTTTSTSSSSSSNLNSGVSSNKLPSFPPFGSMNSSATGSMSTQGNTVQNGQLGGQQSSALQTAGISGESSSLPAQPHPDVSESTMDRDKVGIPTDGD
6) TIDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRAGGPASAQGS
293
651
578
1889
1393
836
456
690
611
1920
1497
901










Molecular Recognition Features






MoRF SequenceStartStop




NANANA