<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26938

Description Mediator complex subunit 25
SequenceMEIEPARPACPAQTWPRARRAAALRRPAPGGAQRRRTSALSTAAAAAAAVAAVAAAARGMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGYTTESLVQKIGEQGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAPPSGASLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPPAQPGAPSMAGTVAPGGVSGPAPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRVMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASAASGQPQPQGAAQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPHQGLGQPQLGPPLLHPPPAQSWPTQLPPRAPLPGKEFPGEGGGLD
Length784
PositionUnknown
OrganismCanis lupus familiaris (Dog) (Canis familiaris)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Canidae> Canis.
Aromaticity0.05
Grand average of hydropathy-0.251
Instability index61.61
Isoelectric point9.32
Molecular weight81699.78
Publications
PubMed=16341006

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26938
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.74|      17|      20|     359|     378|       4
---------------------------------------------------------------------------
  364-  380 (33.80/ 6.66)	PINPLQQAAPGV..GPP...............FS
  383-  416 (23.94/ 6.03)	PAPPLPPGPPGApkPPPasqpslvstvapgpgLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.60|      28|      30|     295|     322|       5
---------------------------------------------------------------------------
  297-  324 (53.69/15.05)	PLQPKQPVPLPPAPPSGASLSAAPQQPL
  625-  649 (34.47/ 6.46)	GLGP...ILEDQARPSQNLLQLRPPQPQ
  744-  763 (34.45/ 6.45)	G.QPQLGPPLLHPPPAQ.SW......PT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.54|      45|     258|     244|     296|       6
---------------------------------------------------------------------------
  209-  259 (56.38/21.52)	PYLL.PAVESTTYSG.....YTTESLVQKIG................eQG....ihfsivsprklPALRLLFEKAAP
  260-  296 (42.47/18.34)	PALLePLQPPTDVSQDPrhmVLVRGLVLPVG.................GGSAPG.......................
  660-  702 (36.69/ 8.44)	.............SGQP..........QPQGaaqappgapqgppgaapGPPPPG...........PILRPQNPGANP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.03|      20|      26|      83|     107|       8
---------------------------------------------------------------------------
   83-  107 (28.52/29.60)	G...TANLGPYFEGlrKHYLLPAieyFN
  109-  131 (32.51/17.84)	GppaETDFGGDYGG..TQYSLVV...FN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.02|      46|      75|     487|     540|       9
---------------------------------------------------------------------------
  487-  540 (66.42/68.61)	PCQVYVNHgeNLKTEQwpQKLIMQLIP.QQ..LLTTLGPLFRNSRMVQfhftNKDLE
  564-  612 (71.60/46.58)	PCEVRVLM..LLYSSK..KKIFMGLIPyDQsgFVNGIRQVITNHKQVQ....QQKLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.62|      24|     292|      29|      67|      10
---------------------------------------------------------------------------
   40-   67 (28.10/39.35)	LStaAAAAAAVAAVaAAARGMVPGsEGP
  337-  360 (41.52/15.01)	LS..AAQVAAQNAV.EAAKNQKAG.LGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26938 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVPLPPAPPSGASLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPPAQPGAPSMAGTVAPGGVSGPAPAQLGAPALG
2) HKQVQQQKLEQQRVMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASAASGQPQPQGAAQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPHQGLGQPQLGPPLLHPPPAQSWPTQLPPRAPLPGKEFPGEGGGLD
291
603
449
784










Molecular Recognition Features






MoRF SequenceStartStop




1) AQTWPRARRAAALRR
12
26