<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26934

Description Mediator complex subunit 12 like
SequencePFLEQDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPDVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDSPSLLAAHSPHMMIGPNSSSIGAPSPGPPGPVMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENVDEHYPKDHDMKMEIFSPMPGESCENANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNNVSSLKNDDFTMRGLRRDGNADDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMGLFNPNGIGSTDTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMLHHPQSTLWGYNLMGQPQQPGFFLQNQSLTPGGSRLDPTGSFVPTNTKQALSNMLQRRSGAMMQPPPLHAITSQQQLIQMKLLQQQQQQRLLRQAQARPFQQGPPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGGVVLSPNYNSRTYPATHSNPALMERLRQMQQQPSGYVQQQASPYLQPLTGSQSRLNHQSLQQSPLVGGGIDAVLTSTHPSLPSVPLPQDPMRPRQPQVRQQQRLLQVFENKQKQMQQPPQPQQTPQPQSQTLGLQAMQPQQPLIPKDTLKATQQSTHTCVHILNELKRRQLSNQPQQGVTPYGHPSHF
Length2120
PositionKinase
OrganismCanis lupus familiaris (Dog) (Canis familiaris)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Canidae> Canis.
Aromaticity0.07
Grand average of hydropathy-0.419
Instability index57.26
Isoelectric point7.87
Molecular weight237258.91
Publications
PubMed=16341006

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26934
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     568.63|     136|     151|    1780|    1929|       1
---------------------------------------------------------------------------
 1679- 1775 (133.44/55.92)	.................................QHHLLLYH.THPMPK.PR......S..............YYLEPLPLppEEEEEE........PTSP.....VSQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRV....DEYPQ..SNIYRV..PPNYSPISSQ
 1780- 1850 (96.26/37.46)	................................................................................................PQSTLWGYNLMGQPQQPGFFLQNQSLTPGGSRLDPTGSFVPTNTKQAL....SNMLQRRSGAMMQ..PPPLHAITSQ
 1851- 1983 (153.85/90.44)	QQLIQMKLLQQqqqqrllrqAqarPFQQGppGDQAALFAAQ.ARPSPQLPQ......YPGLQQAQTMPQGYTMYGTQMPL..QQTPQQqaggvvlsPN.....YN...............SRT...........YPATHSNPALmerlRQMQQQPSGYVQQqaSPYLQPLTGS
 1984- 2119 (185.08/84.34)	QSRLNHQSLQQ.........S...PLVGG..GIDAVLTSTHpSLPSVPLPQdpmrprQPQVRQQQRLLQVFENKQKQM....QQPPQP...qqtpqPQSQTLGLQAM.QPQQP..LIPKDTLKATQQSTHTCVHILNELKRRQL....SN..QPQQGVTPY..GHPSH.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.97|      18|     151|     865|     893|       2
---------------------------------------------------------------------------
  865-  886 (26.76/38.84)	CLIlnPDQTAQVFEGL...CGvvKH
 1114- 1134 (33.21/13.28)	CLL..PQATGKPFPGIrssCD..RH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.35|      18|     151|     488|     508|       3
---------------------------------------------------------------------------
  488-  508 (24.03/28.96)	SCKRS....GkhRAMAV..AKLLeKRQ
  637-  660 (23.32/13.99)	SCENAnpslG..RRMSVngEKLL.KRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.87|      38|     109|    1450|    1505|       6
---------------------------------------------------------------------------
  195-  217 (33.36/ 9.90)	................VEQAMKQW...EYNEKL.AFHMFQEGM
 1275- 1293 (25.75/ 6.27)	GDNLQRQHIKRILQN.....LEQW...................
 1450- 1492 (53.76/68.00)	GQDEQREGLLTSLQNqVNQILSNWreeRYQDDIkARQMMHEAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.70|      34|     203|    1015|    1050|       9
---------------------------------------------------------------------------
 1015- 1050 (57.03/46.33)	TVLSSEWLG..VLKA...LCCSSNHVwgFNDVLCTVDVSDL
 1221- 1259 (50.67/32.53)	TICQQEWVGehCLKEperLCTDKELI..LDPVLSNMQAQKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     149.80|      38|     155|    1407|    1447|      16
---------------------------------------------------------------------------
 1407- 1444 (59.49/32.69)	G.............EELEKGQHLGSSSKKERDR....QKQKSMSLLSQQPFLSLV
 1564- 1601 (54.67/29.06)	G.............SEENKRAYMNLVKKLKKEL....GDKRSESIDKVRQLLPLP
 1614- 1664 (35.64/18.61)	GslidtkgnkiagfDSIDKKQGLQVSTKQKVSPwdlfEGQKNPAPLSWAWF....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.27|      11|     113|     182|     193|      19
---------------------------------------------------------------------------
  182-  193 (19.45/12.96)	SSTGdGPVPVPP
  299-  309 (23.82/11.31)	SSIG.APSPGPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26934 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QPGFFLQNQSLTPGGSRLDPTGSFVPTNTKQALSNMLQRRSGAMMQPPPLHAITSQQQL
2) QQQRLLRQAQARPFQQGPPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGGVVLSPNYNSRTYPATHSNPALMERLRQMQQQPSGYVQQQASPYLQPLTGSQSRLNHQSLQQSPLVGGGIDAVLTSTHPSLPSVPLPQDPMRPRQPQVRQQQRLLQVFENKQKQMQQPPQPQQTPQPQSQTLGLQAMQPQQPLIPKDTLKATQQSTHTCVHILNELKRRQLSNQPQQGVTPYGHPSHF
3) RSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMLH
1795
1863
1694
1853
2120
1778










Molecular Recognition Features






MoRF SequenceStartStop




NANANA