<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26933

Description Mediator complex subunit 23
SequenceMVQMETQLQSIFEDVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCECLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRVPLPGTSCLASASITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRPHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCGMNAREENPWVPDDSYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGEDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSESEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPVVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPPAVPPQAINSGSPAPQSNQVPVSLPVTQ
Length1371
PositionTail
OrganismCanis lupus familiaris (Dog) (Canis familiaris)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Canidae> Canis.
Aromaticity0.10
Grand average of hydropathy-0.010
Instability index46.36
Isoelectric point6.92
Molecular weight156760.53
Publications
PubMed=16341006

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26933
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.58|      26|      89|    1068|    1095|       1
---------------------------------------------------------------------------
 1068- 1095 (47.35/44.45)	DSYYCRLIGRLVDTMAgkSPGPFPNCDW
 1161- 1186 (47.24/36.10)	EPYWIVLHDRIVSVIS..SPSLTSESEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     517.58|     185|     524|     147|     431|       2
---------------------------------------------------------------------------
  191-  402 (306.53/336.51)	RKLYPEgKLPHWLLGNLVSDFVDTFRPTARI..NSICGRcsLLPVVNNsgAICNSWKLDPA.....TLRFPLKGLLPY.DKDLFEPQTALLRYVL...EQPY.SRDMVCNMLGLNKQHKQRCPVLED.........................................................................................................................................................qlvdlvvyamerseteekfddgGTSQLLWQHLSSQLIFFV..LFQFASFPHMV...LSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKN...ALADFLPVMK.LF
  928- 1049 (143.11/58.67)	HKKYPE.KLYFEGLAEQVDPPVQIQSPYLPIyfGNVCLR..FLPVFDI..VIHRFLELLPVsksleTLLDHLGGLYKFhDRPVTYLYNTLHYYEMhlrDRPHlKRKLVHAIIGSLKDNRPQGWCLSD...................................................................................................................................................................................................................................................................
 1225- 1308 (67.95/ 7.35)	...............................................................................................................................tylkcgmnareenpwvpddsyycrligrlvdtmagkspgpfpncdwrfnefpnpaahalhvtcvelmalavsgedvgnallnvvlksqplvprenitawmnaigliitalpepywivlhdrivsvisspsltsesewvgypfrlfdftachqsysemscsytlalahavwhhssiGQLSLIPKFLTEVLLPVVktEFQLLYVYHLVgpfLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNymdPICDFLYHMKyMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     434.65|     103|     262|     525|     627|       3
---------------------------------------------------------------------------
  525-  627 (168.09/112.19)	PLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLG...IKGFISQLLPTV..FKSHAWGI..LHTL......LEMFSYRMHHIQP.HYRVQLL
  655-  757 (127.95/83.46)	LITA..LGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQ....GTWCKDILQTImsFTPHNWAS...HTLscfpgpLQAF.FKQNNVPQ.ESRF...
  790-  892 (138.60/91.08)	PLFLCLLWKMLLETDH..INQIGYRVLERIGARALV....AHVRTFADFLVYEFSTSAGgqqLNKCIEILNDMV..WKYNIVTLdrLILC......LAMRSHEGNEAQVcYFIIQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.05|      10|      28|     138|     147|       7
---------------------------------------------------------------------------
  138-  147 (15.61/10.06)	RDLLKVILEK
  167-  176 (16.44/11.00)	REVIAYILER
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26933 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA