<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26932

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDLAYVCEWEKRPKSDHCPPIPLVCAWSCRNLIAFTTDLRNEEERDLTHMVHIIDTEHPWDVYSVNSGHVEAITCLEWDQSGSRLLSADADGHIKCWSMTDHLANSWENTMGSMVEGDPVVALSWLHNGVKLALHVEKSGASNFGEKFSRVKFSPSLTLFGGKPMEGWIAVTISGLVTVSLLKPNGQVLTSTESLCRLRCRVALADVAFTGGGNIVVATSDGSSASPVQFYKVCVSVVNEKCKIDTEILPSLFMRCTTDPARKDKYPAITHLKFLARDMSEQVLLCASNQNNSIVECWSLRKEGLPVNNIFQQISPVVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVANDTKFFPGLGLALAFHDGSVHIVHRLSLQMMAVFHGSSSQRPVDEQTIKRQRTTGPLVHFKAMQLSWTSLALAGIDSHGKLSMLRISPSMGHVLDMNTSLRHLLFLLEYCMVTGYDWWDILLHVQPNMVQNLVEKLHEEYTRQSAALQQVLATRIVAMKASLCKLSSSTIARVCDYHAKLFLIAISCTLKSLLRPHFLNTPDKSPGDRLTEVCSKITDIDIDKVMINLKTEEFVLEMNTLQSLQQLIQWVGDFVLYLLASLPNQGSPVRPGHSFLRDGASLGMFRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWLCCREESHITEPDDTLIDECCLLPSQLLIPNIDWLPINDGIISKLQNKQLVRLQFGKAPGLIGHTVSSQFDAFVRAPGQPKIDHLRRLHLGAYPTEECKSCTRCGCVTMLKSPNKVTAVKQWEQRWVKNCLCGGLWRRMPLSYS
Length830
PositionTail
OrganismGallus gallus (Chicken)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Phasianinae> Gallus.
Aromaticity0.07
Grand average of hydropathy-0.013
Instability index45.68
Isoelectric point7.88
Molecular weight92828.83
Publications
PubMed=15592404

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26932
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     351.91|     117|     139|     453|     587|       1
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  453-  587 (164.69/151.23)	VLDMNTsLRHLLFLLEYcmvTGyDWWDILLHVQPNmvQ.NLVEKLHeEYTRQSAAL....QQVLATRIVAMKASLCKLSSSTIARVCDYHAKLFLIaisctLKSLL.....RPHfLNTPDkspgDRLTEVC....SKITDIDIDKVMIN
  594-  724 (187.23/116.01)	VLEMNT.LQSLQQLIQW...VG.DFVLYLLASLPN..QgSPVRPGH.SFLRDGASLgmfrELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRL.....LTKLWlccreESH.ITEPD....DTLIDECcllpSQLLIPNIDWLPIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.33|      51|     200|      72|     125|       2
---------------------------------------------------------------------------
   72-  125 (88.91/68.76)	AITCLEW...DQSGSRLLSADADGH..IKCWSMTDH...LANSWENTmgSMVEGD..PVVaLSW
  268-  328 (75.42/47.75)	AITHLKFlarDMSEQVLLCASNQNNsiVECWSLRKEglpVNNIFQQI..SPVVGDkqPMI.LKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.98|      14|      17|     735|     750|       3
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  735-  750 (22.14/19.77)	QLVrlQFGKAPGL..IGH
  755-  770 (22.85/13.19)	QFD..AFVRAPGQpkIDH
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26932 with Med16 domain of Kingdom Metazoa
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