<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26926

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMQREEKQLELTLEALISQVADLKNSLVSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLLRNQVIIPLVLSPDRDEEIMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLITDAARISPDGAQKQIQSLNKMCSNLLEKISKEERESESGGLRQNKQTFNPTDTNALVAAVAFGKGLSNRRPPGSGGSVQSGQPGAGAIIAGASGMQQVPMSSAPAQQQPMLAGVQMAQAGQPGKMPSGIKTNIKSASMHPYQR
Length268
PositionHead
OrganismGallus gallus (Chicken)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Phasianinae> Gallus.
Aromaticity0.03
Grand average of hydropathy-0.524
Instability index52.85
Isoelectric point6.93
Molecular weight29314.03
Publications
PubMed=15592404

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364144
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IBA:GO_Central
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26926
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.42|      26|      28|     122|     149|       1
---------------------------------------------------------------------------
  122-  149 (40.27/30.58)	KqlITDAARISPDGAQKQ.IQSLNKMCSN
  153-  179 (40.16/24.26)	K..ISKEERESESGGLRQnKQTFNPTDTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.27|      25|      36|     185|     209|       3
---------------------------------------------------------------------------
  185-  209 (46.03/24.91)	VAFGKGLSNRRPPGSGGSV.QSGQPG
  223-  248 (42.24/22.29)	VPMSSAPAQQQPMLAGVQMaQAGQPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26926 with Med8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSHEVVPDHLRTKPDPEVEEQEKQLITDAARISPDGAQKQ
2) NLLEKISKEERESESGGLRQNKQTFNPTDTNALVAAVAFGKGLSNRRPPGSGGSVQSGQPGAGAIIAGASGMQQVPMSSAPAQQQPMLAGVQMAQAGQPGKMPSGIKTNIKSASMHPYQR
100
149
139
268










Molecular Recognition Features






MoRF SequenceStartStop




1) IKSASMHPYQR
258
268