<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26922

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPRQKEDELTAVNVKQGFSNQPAFSGDEHGSARNIVINASKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHNWFTDLAGSKPLTILAKKVPILSKKEDVFAYLAKYSVPLLRAAWLIKMTCAYYAAISEAKIKKRQATDPNIEWTQIITRYLREQLAKVAEFYHVTSSQGNSSVVMPQEMEQALKQWEYNEKLSFYMFQEGMLERHEYLTWILDVLEKIRPTDDDILKLVLPLMLQVRAKIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRSDSSNSMETLYHKIFWANQNKDNQEAAPSDEAVVMLLCEWAVSCKRSGKHRAMVVAKLLEKRQAEIEAERCGEAEVLDEKESLSSASLTSSSLPVFQNILLRFLDTQAPSLSDPNSDHEKTEFVNLVLLFSEFTRHDVFSHDAYMCTLISRGDLSITATTRPRSPNGETGDEHYSKDHDMKMEIFSPMPGESCENMNSSLDRRISVASEKSVKRERLREVIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRMILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQEAFPTLETVFTKLQQLSYFDQHQVTSQISSNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRRYHACLILNSEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYSNVQPSNSNLLWDPEFMLDFIENPSAHSINYSMLGKILSDNAANRYSFVCNALMNVCMGHQDAGRINDIANLCAELTACCTVLSSEWLGVVKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDPDAEPGARMTCRLLLHLFRTPQVCLFPQGAGKLFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAILMLGDAEIGSSSVTPVKNEELPVRGLLDEIAEDEMWASSHALKSRGKAVSIETASLSEYARYVLRTICQQEWVGEHCLKEPERLCTDKDLILDPVLSNKQAQKLLQLICYPHGVKECSEGDNPQRQHIKRILQNLDQWTLRQSWLELQLMIKQCMKEPGSGSVAEMNSLLDNIAKATIEVFQQSADLNNNSSNSGIGLFNPNSVGNADTSNTRQNGKKTFLSSSEWRGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQGDVKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMQTNNELFTTVLDMLGVLINGTLASDLSSASQGGPEENKRAYMNLVKKLKKELGDKRSDSIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGHKNPAPLSWAWFGTVRVDRKVIKYEEQQHLLLYHAHPKPKPRSYYLEPLPLPPEEEEEEEPTTPVSQEPERKSGDQDQGKHATDDEKKTKGRKRKSKSGSKADEYPQNNLYRVPPNYSPIPSQMMQHPQSALWGYTIMGQPQQPGFFVQNQPLPPGGSRLDPTSSFVPANTKQALSNMLQRRSGTVLQPPALHAVTPQQQLLQMKLLQQEQQQQRLLRHQAQARSLQQFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQGVNQYGHPSHF
Length1811
PositionKinase
OrganismGallus gallus (Chicken)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Phasianinae> Gallus.
Aromaticity0.07
Grand average of hydropathy-0.411
Instability index52.80
Isoelectric point6.82
Molecular weight203775.97
Publications
PubMed=15592404

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26922
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.10|      24|      27|    1747|    1773|       1
---------------------------------------------------------------------------
 1747- 1773 (36.79/32.22)	LQQEQQQQR...LLRH.QAQARSLQqfPrQG
 1774- 1801 (36.31/20.02)	LQQTQQQQQtaaLVRQlQKQLSSNQ..P.QG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     168.49|      41|     146|     741|     782|       3
---------------------------------------------------------------------------
  741-  782 (70.94/44.26)	LCIVAVLRRyHACLILNSEQTAQVFEGLCGVVKHV..VNPS....ECS
  894-  932 (62.29/34.03)	LC..AELT..ACCTVLSSEWLG.VVKALCCSSNHVwgFNDL....LCS
  946-  976 (35.26/16.34)	TFIAILIAR.............QCF.SLEDVVQHV..ALPSllaaAC.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.29|      12|      31|     592|     603|       4
---------------------------------------------------------------------------
  592-  603 (22.36/16.27)	GVGKERDEARHQ
  624-  635 (21.93/15.78)	GVGDEGQKARKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.84|      10|      29|     983|     992|       5
---------------------------------------------------------------------------
  983-  992 (20.84/10.61)	PGARMTC..RLL
 1013- 1024 (16.00/ 6.55)	PGIRSSCdrHLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.72|      17|      29|    1310|    1326|       6
---------------------------------------------------------------------------
 1310- 1326 (27.75/16.06)	KERDRQKQKSMSLLSQQ
 1337- 1353 (27.97/16.25)	KGQDEQREGLLTSLQNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.06|      13|      29|    1120|    1132|       7
---------------------------------------------------------------------------
 1120- 1132 (24.08/13.28)	CLKEPERLCTDKD
 1152- 1164 (25.98/14.91)	CYPHGVKECSEGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.93|      24|      32|    1526|    1549|       8
---------------------------------------------------------------------------
 1526- 1549 (46.03/32.61)	VSTKQKVSPWD......LFEGHKNPAPLSW
 1555- 1584 (37.90/25.35)	VRVDRKVIKYEeqqhllLYHAHPKPKPRSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.98|      23|      24|    1379|    1402|       9
---------------------------------------------------------------------------
 1379- 1402 (36.29/29.64)	ALQLrLNLV.GGMFDTVQRSTQWTT
 1405- 1428 (33.69/21.80)	ALLL.LQIItSGTVDMQTNNELFTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.24|      27|      32|    1646|    1672|      12
---------------------------------------------------------------------------
 1646- 1672 (51.69/37.31)	PQNNLYRV.....PPNYSPIPSQMMQHPQSAL
 1681- 1706 (31.56/19.06)	PQQPGFFVqnqplPPGGSRL......DPTSSF
 1715- 1741 (42.00/28.53)	LSNMLQRR.....SGTVLQPPALHAVTPQQQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.56|      36|     415|     234|     277|      13
---------------------------------------------------------------------------
  234-  277 (52.88/54.59)	EKLSFYmfqegmlERHEYLTWI.LDVLEKIR..........PTDDDIlKLVLPLM
  651-  697 (51.68/32.70)	QQLSYF.......DQHQVTSQIsSNVLEQITsfasgtsyhlPLAHHI.QLIFDLM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26922 with Med12 domain of Kingdom Metazoa
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