<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26921

Description Mediator of RNA polymerase II transcription subunit 13
SequenceFFFQAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEEMKEEEELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASTGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAIMGESGGAQSAVSHLGAQDGGMLTMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPANNPATWDFVDPTQRVSCSCSRHKLLKRTVGPSRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQDKGDKLQKRPLIPFHHRPSVAEELCMEQDPPGQKLGLAGIDSSLEVASSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQEAESLDPPSVPVNPALYGNGLELQQLSALDDRTVLVGQRVPLTAEVSETTLYCGIRPSNPESSDKWWHSYHLPSVDDAEFRPPELQGERCDAKTEVTSESTALQRLLAQPNKRFKVWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPEGKNAMSLFSSTKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPTFQPFVGSSMFAPLKMLPSQCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTFLPQMEGARKPQEPPISLLLLLQNQHTQPFASLSFLDYISSSSRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRTLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGRTVAQKLTEELVSEWFSQPWGSEESDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQAQVPPGSAGPLASNPGSAAPSAGSAFNPTSNGSSLNPAASSSASGSTGPPVSTSASAPIINQISTTSSSGFSGSVGGQNPSTGASTAERTQGSLGCAGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTEPGETLGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCVGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2189
PositionMiddle
OrganismBos taurus (Bovine)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Ruminantia> Pecora> Bovidae> Bovinae> Bos.
Aromaticity0.07
Grand average of hydropathy-0.385
Instability index58.53
Isoelectric point5.65
Molecular weight240552.60
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26921
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     186.21|      28|      28|    1012|    1039|       1
---------------------------------------------------------------------------
  416-  442 (46.09/16.62)	GPS.RPPTISQPGFSAGPSSSS..SLPPPA
 1003- 1030 (42.71/14.86)	NSA.APASNSGAGVLPSPATPR.FSVPTPR
 1031- 1058 (37.38/12.08)	TPR.TPRTPRGGGTASGQGSVK.YDSTDQG
 1522- 1546 (31.92/ 9.24)	SAG..PLA.SNPG.SAAPSAGSaFN.PTSN
 1547- 1568 (28.11/ 7.26)	GSSlNPAASSSASGSTGP........PVST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.55|      25|      28|    1105|    1129|       2
---------------------------------------------------------------------------
 1105- 1129 (51.64/39.01)	NFDSC.CICACN..MNIK.GADVGLYIPD
 1132- 1160 (36.91/25.29)	NEDQYrCTCGFSaiMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.10|      20|      22|     927|     947|       3
---------------------------------------------------------------------------
  927-  947 (34.45/18.67)	MFAPLKMLPSQC.LLPLKiPDA
  949-  969 (34.64/15.03)	LFRPSWAIPPKIeQLPMP.PAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.87|      20|      22|    1585|    1606|       4
---------------------------------------------------------------------------
 1585- 1606 (31.34/23.99)	GFSGSVGGQNPstGASTAERTQ
 1607- 1626 (37.54/22.37)	GSLGCAGDTEP..GQSSSQPSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.69|      12|      23|     522|     533|       6
---------------------------------------------------------------------------
  522-  533 (24.80/10.90)	NPMDSPHSPISP
  548-  559 (22.89/ 9.42)	ESLDPPSVPVNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.19|      18|      22|    1979|    1996|       7
---------------------------------------------------------------------------
 1955- 1971 (21.38/ 9.89)	.TALNMQSS...QLNTPQDAS
 1979- 1996 (31.10/18.28)	PTSSTIQVA...PANYPNEDG
 1999- 2019 (26.70/14.48)	PNNDDMFVDlpfPDDMDNDIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.71|      17|      22|    1354|    1370|       8
---------------------------------------------------------------------------
 1366- 1387 (20.43/ 7.57)	GYDKDfltiSPFSLPFwE...RLLL
 1391- 1410 (23.27/ 9.74)	GGHRD....VAYIVVC.PeneALLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.75|      20|      26|    1719|    1744|       9
---------------------------------------------------------------------------
 1725- 1744 (39.75/34.68)	YLKSM.....AFSVYCQCR...RPLPTQ
 1746- 1773 (24.00/ 6.30)	HIKSLtgfgpAASIEMTLKnpeRPSPIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.69|      25|      27|    1837|    1863|      10
---------------------------------------------------------------------------
 1837- 1863 (39.91/36.09)	I...ALPNRSRRSKVSarKIGLQKLWEWCV
 1866- 1893 (39.78/28.26)	VqmtSLPWRVVIGRLG..RLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.28|      15|      17|     571|     586|      11
---------------------------------------------------------------------------
  571-  586 (21.39/17.76)	LSA.LDDRTVLVGQRvP
  587-  602 (22.88/13.56)	LTAeVSETTLYCGIR.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.55|      11|      17|    1210|    1220|      12
---------------------------------------------------------------------------
 1210- 1220 (20.74/ 8.82)	QHTQPFASLSF
 1229- 1239 (22.81/10.41)	RQTLPCVSWSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.01|      16|      17|     867|     882|      13
---------------------------------------------------------------------------
  867-  882 (27.45/18.18)	SETVTALGM.MESPMVS
  885-  901 (22.56/13.46)	STQLTEFKMeVEDGLGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.43|      20|      23|      45|      64|      14
---------------------------------------------------------------------------
    4-   27 (29.09/17.24)	QAELTGI...........kWRRynfGGHGDCGPII
   45-   64 (39.44/26.65)	QANLLCV............WRR...DVKPDCKELW
   71-  101 (20.89/ 9.78)	EPNLVGVihhelqvveeglWEN...GLSYECRTL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.08|      20|    1104|     667|     695|      15
---------------------------------------------------------------------------
  672-  692 (32.57/30.87)	LHFLDPLpLSQQPGDSLGEVN
  785-  804 (34.51/ 7.97)	LHDLDNI.FDNSDDDELGAVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.33|      49|    1264|     146|     195|      17
---------------------------------------------------------------------------
  146-  195 (86.37/71.12)	AFTFFlHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAP..FQVLVS.....PYG
 1412- 1467 (78.96/59.49)	AKTFF.RDLSAVYEMCRLGQHKPICKVLRDGIMRVGRTVAQklTEELVSewfsqPWG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.93|      26|      28|    2047|    2074|      18
---------------------------------------------------------------------------
 2047- 2074 (37.05/26.00)	GsHFQhSRSQGERL...LSREAPEELKQQPL
 2077- 2105 (44.88/22.63)	G.YFV.STAKAENLpqwFWSSCPQAQNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     254.81|      83|     482|     209|     299|      19
---------------------------------------------------------------------------
  209-  299 (129.18/105.29)	DPATrklIEEWQYFYPMVLKKK.EEMKEEEEL...GYDDDFPVAvEVIVGGVRMVYP...SAFVLISQNDIPVPQSVAStgGHitVGQQGLGSVKD..PS
  693-  784 (125.63/79.69)	DPYT...FEDGDIKYIFTANKKcKQGTEKDSLkknKSEDGFGTK.DVTTPGHSTPVPegkNAMSLFSSTKTDVRQDNAA..GR..AGSSSLTQVTDlaPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.02|      19|      26|     336|     354|      20
---------------------------------------------------------------------------
  336-  354 (35.28/21.57)	MLTMHSPKRSGKIPPKLHN
  365-  383 (31.74/18.53)	ILNRTQSKRSQMSTPTLEE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26921 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CSRHKLLKRTVGPSRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQDKGDKLQKRPLIPFHHRPSVAEELCMEQDPPGQKLGLAGIDSSLEVASSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQEAESLDPPSVPVNPALY
2) GILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
3) GTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPEGKNAMSLFSSTKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGTEDRPLGKDGRAAVP
4) KECILNRTQSKRSQMSTPTLEEEPANNPATWDFVDPT
5) QTPPAAAQAQVPPGSAGPLASNPGSAAPSAGSAFNPTSNGSSLNPAASSSASGSTGPPVSTSASAPIINQISTTSSSGFSGSVGGQNPSTGASTAERTQGSLGCAGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSA
6) SVASTGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAIMGESGGAQSAVSHLGAQDGGMLTMHSPKRSGKIPPKLHN
7) VGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
425
2039
735
382
1528
297
1002
582
2087
851
418
1667
374
1099










Molecular Recognition Features






MoRF SequenceStartStop




NANANA