<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26919

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGTAKNVNFNPAKISSNFNSIITEKLRCNTLPDIGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHIDPFTEWTQIITKCLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEMAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPTTPAPQPPSSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKLEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDSDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDLSPPDKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGSRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNAASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELENGQHLDSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVTNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELAERQSDSLEKVYQLLPLPKPTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEQGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEGPYGVTVPPDLLHHANPSSISHLSYRQSSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPASYKTSVYRQQQPAVPQGQRLRQQLQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMIGTMTPLGPQGVQAGIRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQAHQQQQQQAAPPQPQPQSQPQVAAGFQPLPPAPTGFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2159
PositionKinase
OrganismBos taurus (Bovine)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Ruminantia> Pecora> Bovidae> Bovinae> Bos.
Aromaticity0.07
Grand average of hydropathy-0.497
Instability index58.45
Isoelectric point6.66
Molecular weight240878.41
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26919
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     324.65|      38|      38|    2010|    2047|       1
---------------------------------------------------------------------------
 1859- 1896 (40.98/ 9.53)	..GLEPASY.KTSVYR..........Q...QQPAVPQGQRLR....QQLQSQ....GmlGQS
 1899- 1947 (38.26/ 8.50)	HQMTPSSSYgLQTSQGytpyvshvglQ...QHTGPAGTMVPP....SYSSQP....Y..QST
 1948- 1976 (33.74/ 6.79)	HPSTNPTLV.DPTRHL..........Q...QRPSGYVHQQAP....T...............
 1978- 2009 (40.16/ 9.22)	GHGLTST.......QR..........F...SHQTLQQTPMIG....TMTPLG....P..QGV
 2010- 2047 (71.40/21.07)	QAGIRSASI.LPEQQQ..........Q...QQQQQQQQQQQQ....QQQQQQ....Q..QQQ
 2048- 2082 (56.68/15.49)	QYHIR.......QQQQ..........QilrQQQQQQQQQQQQ....QQQQQQ....Q..QQQ
 2106- 2150 (43.42/10.46)	AAGFQPLPP.APTGFQ..........R...QGLQQTQQQQQTaalvRQLQQQlsntQ..PQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     343.66|     113|     348|     208|     348|       2
---------------------------------------------------------------------------
  208-  325 (187.16/198.96)	GPAGSGGCGSTIGPLPHDVEMairQWdYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRpGEDELLKLLLPLLLRYSGEFV....QSAYLSR.RLAYFCTRRLALQLDGVSSHSSHVM.SAQST
  551-  605 (64.82/32.31)	GSIASGSLSAPSAPIFQDVLL...QF.LDTQAPMLTDPRSESERVEFFNLVLLFCELIR.................................................................
 1455- 1534 (91.68/54.14)	........................................LLSQQPFLSLVLTCLK....GQDEQREGLLTSLYSQVHQIVtnwrDDQYLDDcKPKQLMHEALKLRLNLVGGMFDTVQrSTQQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.20|      32|     222|    1399|    1451|      12
---------------------------------------------------------------------------
 1213- 1246 (52.28/20.68)	AELKGS..GFTVTGGTEELpeEEGGG.GSGSRRQGGR
 1413- 1447 (46.92/32.49)	AKLPTSvqGHVLKAAGEEL..ENGQHlDSSSRKERDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     241.77|      57|     222|    1576|    1640|      13
---------------------------------------------------------------------------
 1576- 1640 (84.07/66.75)	ADMSSISQGsmEENKRAYMnlvkkLRKELAERQSdSLEKVYQLLPLP......KPTRDV.......ITCEPQGSLIDT
 1691- 1740 (87.92/49.86)	VD.RRVARG..EEQQRLLL.....YHTHLRPR.....PRAYYLEPLP......LPPED.........EEPPAPTLLEP
 1796- 1852 (69.77/37.79)	ANPSSISH....................LSYRQS.SIGLYTQNQPLPaggprvDPYRPVrlpmqklPTRPPYPGVLPT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26919 with Med12 domain of Kingdom Metazoa
Unable to open file!