<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26919

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGTAKNVNFNPAKISSNFNSIITEKLRCNTLPDIGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHIDPFTEWTQIITKCLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEMAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPTTPAPQPPSSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKLEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDSDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDLSPPDKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGSRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNAASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELENGQHLDSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVTNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELAERQSDSLEKVYQLLPLPKPTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEQGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEGPYGVTVPPDLLHHANPSSISHLSYRQSSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPASYKTSVYRQQQPAVPQGQRLRQQLQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMIGTMTPLGPQGVQAGIRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQAHQQQQQQAAPPQPQPQSQPQVAAGFQPLPPAPTGFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2159
PositionKinase
OrganismBos taurus (Bovine)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Ruminantia> Pecora> Bovidae> Bovinae> Bos.
Aromaticity0.07
Grand average of hydropathy-0.497
Instability index58.45
Isoelectric point6.66
Molecular weight240878.41
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26919
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     324.65|      38|      38|    2010|    2047|       1
---------------------------------------------------------------------------
 1859- 1896 (40.98/ 9.53)	..GLEPASY.KTSVYR..........Q...QQPAVPQGQRLR....QQLQSQ....GmlGQS
 1899- 1947 (38.26/ 8.50)	HQMTPSSSYgLQTSQGytpyvshvglQ...QHTGPAGTMVPP....SYSSQP....Y..QST
 1948- 1976 (33.74/ 6.79)	HPSTNPTLV.DPTRHL..........Q...QRPSGYVHQQAP....T...............
 1978- 2009 (40.16/ 9.22)	GHGLTST.......QR..........F...SHQTLQQTPMIG....TMTPLG....P..QGV
 2010- 2047 (71.40/21.07)	QAGIRSASI.LPEQQQ..........Q...QQQQQQQQQQQQ....QQQQQQ....Q..QQQ
 2048- 2082 (56.68/15.49)	QYHIR.......QQQQ..........QilrQQQQQQQQQQQQ....QQQQQQ....Q..QQQ
 2106- 2150 (43.42/10.46)	AAGFQPLPP.APTGFQ..........R...QGLQQTQQQQQTaalvRQLQQQlsntQ..PQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     343.66|     113|     348|     208|     348|       2
---------------------------------------------------------------------------
  208-  325 (187.16/198.96)	GPAGSGGCGSTIGPLPHDVEMairQWdYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRpGEDELLKLLLPLLLRYSGEFV....QSAYLSR.RLAYFCTRRLALQLDGVSSHSSHVM.SAQST
  551-  605 (64.82/32.31)	GSIASGSLSAPSAPIFQDVLL...QF.LDTQAPMLTDPRSESERVEFFNLVLLFCELIR.................................................................
 1455- 1534 (91.68/54.14)	........................................LLSQQPFLSLVLTCLK....GQDEQREGLLTSLYSQVHQIVtnwrDDQYLDDcKPKQLMHEALKLRLNLVGGMFDTVQrSTQQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.20|      32|     222|    1399|    1451|      12
---------------------------------------------------------------------------
 1213- 1246 (52.28/20.68)	AELKGS..GFTVTGGTEELpeEEGGG.GSGSRRQGGR
 1413- 1447 (46.92/32.49)	AKLPTSvqGHVLKAAGEEL..ENGQHlDSSSRKERDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     241.77|      57|     222|    1576|    1640|      13
---------------------------------------------------------------------------
 1576- 1640 (84.07/66.75)	ADMSSISQGsmEENKRAYMnlvkkLRKELAERQSdSLEKVYQLLPLP......KPTRDV.......ITCEPQGSLIDT
 1691- 1740 (87.92/49.86)	VD.RRVARG..EEQQRLLL.....YHTHLRPR.....PRAYYLEPLP......LPPED.........EEPPAPTLLEP
 1796- 1852 (69.77/37.79)	ANPSSISH....................LSYRQS.SIGLYTQNQPLPaggprvDPYRPVrlpmqklPTRPPYPGVLPT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26919 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHANPSSISHLSYRQSSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYPGVLPTTMTGVM
2) FSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKLEGTLGVLY
3) GAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSV
4) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGTAKNVNF
5) LEPASYKTSVYRQQQPAVPQGQRLRQQLQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPADPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMIGTMTPLGPQGVQAGIRSASILPEQQQQQQQQQQ
6) QQAHQQQQQQAAPPQPQPQSQPQFQRQGLQ
7) VLKAAGEELENGQHLDSSSRKERDRQKQKS
1719
687
627
15
1871
2068
1426
1869
726
674
64
2017
2097
1455










Molecular Recognition Features






MoRF SequenceStartStop




1) ERKKK
2) MAAFGI
3) NIFGRY
4) YHIRQQQQQILRQ
1764
1
2126
2035
1768
6
2131
2047