<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26915

Description Mediator complex subunit 12 like
SequencePFLQQDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRPATDPNLEKNAEWTQISTRYLREQLAKISDFYHLASSAGDGPVPVPPDVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDSPSLLAAHSPHVIIGPNSSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAVFTDVGHNDLWHKEDEEVQTSKAFIPGASRSFHMCPSSALLFLKELESVDFSNFSPTVPCDQGKSQPIPLLPYVKLGLHPPPLQKLEGMLGLILVQLALLQHLTILKTPFDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSNTETGVLEAPLSLINSQNLSILLGDEGQKARKSKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSLSSACSKVKQTIYNNVIPANSNLRWDPDFMMDFIENPSARSVNYSVLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRRDGNAEDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPVAEMNNLLDNIAKATIEVFQQSADLNNNSSNAGMGLFNPNKAAGIFSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPTPKPRSYYLEPLPLPPEEEEEEPTSPISQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRVDVSMGNALKGIKPITFPKEVMHHPQSALWGYNLMGQPQQPGFFLQNQSVTPGKHLTDYYCHASLPQNRHFYFAVLKNVVPGWTPLAPSSPPTPIYREQARAKPKAKCLKTNMLSGRRGQLSYYSLELVSPGENQGMTMPQGYTMYGTQMPLQQTPQQQAGSVVLSPTYNSRTYPAAHSNPALMERLRQMQQPPSGYVQQQASPYLHPLTGSQRLNHQSLQQSPLVGGGIDAVLTSAHPNLPSVPLSQDPMRPRQPQVRQQQRLLQERRRKQHQEWELHFKTSHFQIIEMQQPQQPPQPQQPPQPQGSSQTQSQTLGLQTMQPQQPLVRPSISKPNMAPPFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHP
Length2174
PositionKinase
OrganismBos taurus (Bovine)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Ruminantia> Pecora> Bovidae> Bovinae> Bos.
Aromaticity0.07
Grand average of hydropathy-0.356
Instability index54.69
Isoelectric point8.07
Molecular weight242901.92
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26915
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.46|      34|      35|    1891|    1924|       1
---------------------------------------------------------------------------
 1891- 1924 (54.80/33.20)	EQARAKPKAKCL.KTNMLSGRRGQLSYYSLELVSP
 1927- 1960 (56.18/34.26)	NQGMTMPQGYTMyGTQMPLQQTPQQQAGSV.VLSP
 2099- 2123 (39.48/21.45)	.QGSSQTQSQTL.GLQTM...QPQQ.....PLVRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     230.90|      81|     156|    1809|    1890|       2
---------------------------------------------------------------------------
 1809- 1864 (90.48/43.39)	.........................................................................................................TFPKEVMHHPQSALWGYNLMGQPQQ.PGFFLQNQSvTPGKH.LT..DYYCHASLPQNRHF
 1865- 1890 (26.60/ 6.44)	YFAVLKNVVPGW..TPLA..PSSPPTPIYR.......................................................................................................................................
 1966- 2019 (62.00/25.29)	..............................eqarakpkakclktnmlsgrrgqlsyyslelvspgenqgmtmpqgytmygtqmplqqtpqqqagsvvlsptynsrTYPAA...HSNPAL..MERLRQMQQpPSGYVQQQA.SPYLHpLTgsQRLNHQSLQQSPLV
 2023- 2098 (51.83/19.72)	IDAVLTSAHPNLpsVPLSqdPMRPRQPQVR...................................................qqqrllqerrrkqhqewelhfktsHFQIIEMQQPQQPPQPQ....QPPQ.P.................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.45|      15|      19|    1372|    1390|       3
---------------------------------------------------------------------------
 1372- 1389 (20.53/19.92)	AEMNNlldNIAKATIEVF
 1393- 1407 (26.93/11.59)	ADLNN...NSSNAGMGLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     286.00|      93|     156|     902|    1017|       4
---------------------------------------------------------------------------
  902-  965 (97.44/44.80)	....................................................................................................YTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGL...CGVVKHV.........VNPSECSSPERCILAYLYDLYVS
  966- 1003 (14.97/81.93)	CSHLRS..KFGDLFS.LSSACSKVKqtiynnvipANSNLRW.......................................................................................................................................
 1063- 1122 (59.04/60.36)	.........................................dpdfmmdfienpsarsvnysvlgkilsdnaanrysfvcntlmnvcmghqdagrindianFSSELTAC..........CTVLSSEWLG.VLKAL...CCSSNHVwgfndvlctVDVSDLSFHD.S.LATFIAILIA
 1125- 1209 (114.55/ 0.00)	CFSLEDvvQHVALPSlLAAACGDAD.........AEPGARM.............................................................T..CRLLLHLFRAPQACLL..PQATGKPFPGIrssCD..RHL.........LAAAHNSIEVGAVFAVL......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     152.69|      39|     156|    1312|    1350|       5
---------------------------------------------------------------------------
 1272- 1312 (36.83/18.84)	ARYVLRTICQQEW...VGEhClKEPERLctDKELIlDPVLSN.........mQ
 1313- 1350 (63.59/38.39)	AQKLLQLICYPHG...IKE.C.TEGDNL..QRQHI.KRILQN.....LEQW..
 1468- 1514 (52.27/30.12)	KQKSMSLLSQQPFlslVLT.C.LKGQDE..QREGL.LTSLQNqvnqiLSNW.R
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.99|      64|     156|       1|      76|       6
---------------------------------------------------------------------------
    1-   76 (96.48/93.83)	PFLQQD.ELTAVNVKQgFNNQPAFTGD.EH..GSARN..IVINPSKIGA.....YfssilAEKLKLNTFQDTgkkkpqVNAKDNY..WL
  155-  231 (88.50/58.25)	PNLEKNaEWTQISTRY.LREQLAKISDfYHlaSSAGDgpVPVPPDVEQAmrqweY.....NEKLAFHMFQEG......MLEKHEYltWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.40|      49|     165|     678|     730|      16
---------------------------------------------------------------------------
  678-  730 (80.09/59.69)	GKSQPIPLLPYVKL..GLHPPPLQklegMLGLILVQLALLQHLTILKTPFDESSS
  846-  896 (77.31/48.43)	GTSYHLPLAHHIQLifDLMEPALN....INGLIDFAIQLLNELSVVEAELLLKSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.99|      22|      27|    1552|    1575|      17
---------------------------------------------------------------------------
 1552- 1575 (33.79/33.77)	WTTdwALLLLQIITSGTVDMHTNN
 1578- 1599 (36.20/25.97)	FTT..VLDMLGVLINGTLASDLSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.68|      14|      18|    1654|    1668|      19
---------------------------------------------------------------------------
 1654- 1668 (19.75/16.93)	GSLIDTKgNKIAGFD
 1675- 1688 (25.93/16.51)	GLQVSTK.QKVSPWD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.29|      21|      27|    1731|    1751|      22
---------------------------------------------------------------------------
 1731- 1751 (37.93/22.71)	PKPRSYYLEPLPLPPEEEEEE
 1760- 1780 (33.35/18.97)	PERKSAELSDQGKTATDEEKK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26915 with Med12 domain of Kingdom Metazoa
Unable to open file!