<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26903

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMQNNVSPPQQQAQQIENVSAFPPPPQFYKLYLNYTKDQFKDRENKEKIDTTTTNNNNNNNNNEEKQQSQDDQQQMNVDDDKDKKKDKKAELNKPLPPPIPPKMGSHYVQFGQNYSTVDMLPSLDESGSKQLYPKGDIEPIAELKKLNRSILFNYLQLLETLIENPTNYQKKIDDISLLFINFHHLLNSYRPHQARETLLSIMNEQIKQKFQSNETIKKSLEICKESIKKSFNHLQVETTNPITPNPNINPQSTDGLAQTSQPQKPQQNQNNDINMGETNWMDQLLDEMLEIN
Length292
PositionMiddle
OrganismDictyostelium purpureum (Slime mold)
KingdomAmoebozoa
LineageEukaryota> Amoebozoa> Evosea> Eumycetozoa> Dictyostelia> Dictyosteliales> Dictyosteliaceae> Dictyostelium.
Aromaticity0.07
Grand average of hydropathy-1.137
Instability index46.54
Isoelectric point5.37
Molecular weight33900.45
Publications
PubMed=21356102

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26903
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.00|      18|      19|     229|     247|       3
---------------------------------------------------------------------------
  229-  247 (28.77/20.89)	KSFNHLqVETTNPITPNPN
  251-  268 (32.23/18.64)	QSTDGL.AQTSQPQKPQQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.01|      15|      18|      60|      76|       4
---------------------------------------------------------------------------
   62-   76 (25.59/15.77)	NEEKQQSQDDQQQMN
   78-   92 (23.42/ 7.47)	DDDKDKKKDKKAELN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.23|      16|      73|      21|      37|       6
---------------------------------------------------------------------------
   22-   37 (32.54/14.88)	PP..PPQFYKLYLNYTKD
   96-  113 (28.69/ 8.76)	PPpiPPKMGSHYVQFGQN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26903 with Med7 domain of Kingdom Amoebozoa
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