<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26901

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDQQQTQPPQQPQQQIPHPVDPNLPIQSDLQNGNISLSLVIHRLVEQSYNNLLGLTENLPKANDLERKKALVDYLDGTREKFLRLLVLMKWSEHVPTLTKANNIINLLNQEDSYFREAADSLINTQYGLVNARAPIYDVPTAIDVLTTGTYQRMPTSIKKVIPPPMLKPSQIDSTLQRLDDIIKYKLFISSIPKEFEPIQVAIKIEISINIFLILSADGKAHIVVKDEYDVYITIDGGSEKSNWLILSLNLFVYSKRNSSGEGPIQVAYDERIRKVIERVQNRISSSPNPLYELHNIIHYLCISSQMDILASQVENLKKTILKNNIRCVFGKDQSITVFYWLPEDINLIGVTQTTLGNLNPSKNTNFKIFIDDSQKIKISHFPPVVHPKNDNYFNISNLNIETILLQAIELNAYHKVFHLYGKLLDSKLSDGLNTNQNASTRPTNLLMATKQQQNNSILNRSFHLNDVKLIMSSRFSDENQSISNHNDHLPTVLRVMLYGSKFLDVSVNFTNGKFSLIKSSNYIELTSHLEQKLNNNPNEIKSIVNIFKLKSLLTCFEEASLFLGLECFYKIPLQLTNNNNSNNNQIANELFSESNFICISLPKETDPIIIVISIKANCFTPSFHLLFCKLLQKSTIMTLESIIKLENESLSNLLKDCPIGGNSNNRQPFQTYVSKLLEKIIEASNQKINLLSIQSYLKKENINFIQPPSISTTSSTSPLFISNPQQLLSSPSTSSPSSANSTPTLLSSNPALLFSSNQLSTSLFSSPSDDNSIVFFFDEKQIEKVSPFLKNHITPQTPITVVFNKEDYFVSFTQQRPFQYKRYNNDILKLSEQEIEYENHLISNGPNYSYNNGNWVFKYPKTSDWLNHFHSDLLAISKISNISSQLLKQIETLENYKQLITLVSVKPMEIEFICSIESPKTCTNIRFFIDKTSNDIQIGFNPYTNPLVNYFAKDINQSPNNDITNALRAIINSNDISIYINGLISPLEITLFLPLEILVIPRSLYQIRLLYKNLYGIDIKLISHEYCAIGDSFYSLNASKQVRLTSINQLHSFMEQRISLQALDNPLGHRTFWLLPIKQFLKTVNRIFIYLHSLNTFKNTQGLMKNYFILQSQVNAHINKFSNEYYLVNISIRDFTHFEFDMRCIKDDILKPEEIDTFRRYFKKKILSLSYRNQALSSCIQMLTLPPFILSEIIRLLLEITGPKFDGFTIELCLNTSNVNNQKSKESFFHNSDEKQIYLILRYLTSIRNENASVPPQDQFLDIPIIYNYSSDKKSFQYWNKGITDLNLTKKLASPFDDLKKKYVEEVGKTVIDQITTILVQNPNSKPNPLSLFFKAFLEKVKLMLSNQNNIIATSPQ
Length1358
PositionTail
OrganismDictyostelium purpureum (Slime mold)
KingdomAmoebozoa
LineageEukaryota> Amoebozoa> Evosea> Eumycetozoa> Dictyostelia> Dictyosteliales> Dictyosteliaceae> Dictyostelium.
Aromaticity0.09
Grand average of hydropathy-0.241
Instability index44.03
Isoelectric point8.38
Molecular weight155605.48
Publications
PubMed=21356102

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26901
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.99|      30|      34|     709|     742|       1
---------------------------------------------------------------------------
  709-  726 (15.59/10.20)	.....................PSIstTSSTSPLFISN...PQ
  729-  759 (46.09/34.42)	LSSPSTSSPSSANS......tPTL..LSSNPALLFSS...NQ
  760-  797 (37.31/18.95)	LSTSLFSSPSDDNSivfffdeKQI...EKVSP.FLKNhitPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.48|      15|      38|     934|     948|       2
---------------------------------------------------------------------------
  934-  948 (30.10/16.10)	SNDI.QIGFNPYTNPL
  953-  968 (20.64/ 8.50)	AKDInQSPNNDITNAL
  974-  988 (25.74/12.59)	SNDI.SIYINGLISPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.26|       9|      21|     671|     681|       3
---------------------------------------------------------------------------
  671-  681 (11.13/11.57)	QTYVSKllEKI
  695-  703 (16.13/ 8.66)	QSYLKK..ENI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.98|      33|     146|       9|      41|       4
---------------------------------------------------------------------------
    9-   41 (59.95/36.33)	PQQPQQQIPHPVDPNLPIQSDLQNGN..ISLSLVI
  155-  189 (53.04/31.20)	PTSIKKVIPPPMLKPSQIDSTLQRLDdiIKYKLFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     159.36|      44|     146|     332|     382|       5
---------------------------------------------------------------------------
  332-  379 (69.62/48.09)	KDQSI........TVFYWLPEDINLIGVTQTtlgnLNPSKN.TNFKI.FIDDSQKIKI
  479-  526 (44.49/25.01)	ENQSIsnhndhlpTVLRVMLYGSKF..........LDVSVNfTNGKFsLIKSSNYIEL
  899-  931 (45.25/23.93)	..QLI........TLVSVKPMEIEFICSIES......PKTC.TNIRF.FID.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.08|      40|     146|    1087|    1136|       6
---------------------------------------------------------------------------
  416-  471 (41.04/15.38)	KVFhLYgklLDSklsdgLNTNQNastrpTNLLMATK...QQQNNSILNRsFHlNDVKLI
 1087- 1129 (69.04/54.82)	RIF.IY...LHS.....LNTFKN.....TQGLMKNYfilQSQVNAHINK.FS.NEYYLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.73|      24|      27|     818|     844|       7
---------------------------------------------------------------------------
  818-  844 (30.66/29.87)	PfQYKrYNND..ILKLSEQEiEYENHLIS
  847-  872 (44.08/25.59)	P.NYS.YNNGnwVFKYPKTS.DWLNHFHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.72|      27|      27|     590|     616|       9
---------------------------------------------------------------------------
  191-  206 (18.15/ 7.00)	.............SIPKEFEPIQVAIK.IE
  590-  616 (47.56/32.94)	ELFSES..NFICISLPKETDPIIIVIS.IK
  618-  645 (34.01/20.99)	NCFTPSfhLLFCKLLQKST..IMTLESiIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.88|      29|      34|      52|      84|      10
---------------------------------------------------------------------------
   52-   84 (37.37/33.17)	LLGL...TENLPkanDLERKKALVDYLDgTREKFLR
   85-  116 (42.51/24.40)	LLVLmkwSEHVP...TLTKANNIINLLN.QEDSYFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.60|      14|     555|     310|     323|      14
---------------------------------------------------------------------------
  310-  323 (21.62/12.64)	LA.SQVENLKKTILK
  875-  889 (15.99/ 7.21)	LAiSKISNISSQLLK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26901 with Med14 domain of Kingdom Amoebozoa
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