<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26894

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGGRNGGAHSNHDRDQPTQQMNGASRHAMEGSGDVAGRQAEANGPLASVGPPRMNDLPGAIQHVTDNFVPLGFLIGRLAQKTHNNLQDMIRELARKPVAGMVTNGVDAAGPEDGSVENVEKKKRLLEFARSEHANWVKALVITEWSKKATQISKLIDLENHMFEEELVKYEQAVFTMLNLKRNLNAARVPSPDLKTALQVLSQGNGPWMPDLGFIEPAPLTAEEQLRWLDDISTLLSLRLNLDDYDTIPYQFRDYTIRSGRATFRVEGEFEVDVTIASDDFTEQLWFLDLRFLFTPAPADLTEGLRTALEDQVNGVLAAEGLAGCYRSLHEYVMTHKVNELRRQALELGRGRWVETVRVEQLNRAISVQYWTSRYGSTGPKSWIIIGVHSGRADTAKETADEGGDEQQTSRLGLRWFRDGKEVKTVAVAVVEGSTVSAERVLMAVIGLHVEHILTGMHERLAAKPLFATRRAALRLHISQTDPGASFLEMQLTHRDRVSRVVMHNEGRINAGAGGGASSTRDPIEEGLAMLDSVRCASAQEDLGRRAKSFGWTTVRGLVVRSEELRQVVNLRDTYQVLWLKRQDWDAQWHVLACLSLSGDRWWLVKLDTAESGTRIKAHMSLPLGTNPADLDDSFFSDLTVFATGIAAQYTDIQELIRRKKPVRAANVWSASVAPRARLPALTIRLSELLKSSPQQQQQGSQTLQFGLGRHAANNIMSAALDDRQQRRKTAWATDFVHLVFRGIDMDPDQTTWTTERERRMGVLAEARLVVTDRAKFRLLGGRTDHDVAFNGRTGQFCLYLRATVGQSVMDTLVSRLQAIERVVGFLDAIRREASRGVRCETVTLRRLVFSYGDAGQRRWTVTVDLGGGGGGERREERRSTALSSSVRLRLERGCPHLRVVDFLGRVAGDAATAEAVPFFLTTTLGLHRALDRLEDVWEQMQLRNVGMLGIFPRALDWFVLRFLFPSPPQGRLRQLVLEIRLRMRSGVSLWQVRRIEAVSGGGGAAADPAHEDDLGRVLRSVFERRGRGWKGLQTAAVASPFGREEEEDSRTDAKEEKIDSKMDAKVDMKADKTDRTDGLCGIEACLAEIDERVRSLLPVPSALPAGMSMAQLQQRRAQAAAHAHQQAQQQQQQQQQQQAHQQAQTARMG
Length1152
PositionTail
OrganismGrosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus) (Graphiocladiella clavigera)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Grosmannia.
Aromaticity0.06
Grand average of hydropathy-0.409
Instability index51.14
Isoelectric point8.46
Molecular weight128436.00
Publications
PubMed=21262841

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26894
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     354.66|      93|     129|     229|     350|       1
---------------------------------------------------------------------------
  153-  227 (83.96/39.79)	.........QISKLIDLENHMFEE.ELVKYEqavFTMLNLKRNLNAARVPSpDLKTALQVLSQG..NGP...WMPDLGFI.EPAPLTAEEQ..................
  229-  324 (147.34/89.38)	RW.....LDDISTLLSLRLNLDDY.DTIPYQ...FRDYTIRSGRATFRVEG.EFEVDVTIASDDFTEQL...WFLDLRFLFTPAPADLTEGlRTALEDQVngVLAAEGL
  354-  450 (123.36/99.46)	RWvetvrVEQLNRAISVQYWTSRYgSTGPKS...WIIIGVHSGRADTAKE....TAD.EGGDEQQTSRLglrWFRDGKEVKTVAVA.VVEG.STVSAERV..LMAVIGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.73|      58|     475|     490|     566|       2
---------------------------------------------------------------------------
  490-  566 (85.49/74.29)	LEMQLTHRDRVSrvvMHNEGRINAGAGGGASSTrDPI.EEglamldsvrcasaqeDLGRRAKS.F.....GWTTVRGLVV.....RSEE
  980- 1049 (83.24/41.75)	LEIRLRMRSGVS...LWQVRRIEAVSGGGGAAA.DPAhED...............DLGRVLRSvFerrgrGWKGLQTAAVaspfgREEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     207.09|      63|     438|     647|     709|       5
---------------------------------------------------------------------------
  647-  709 (107.42/71.62)	GIAAQYTDIQELIRRKKPVRAANVWSASVAP....RARLPALTIRLSELLKSSPQQQQ..QGSQTLQFG
 1084- 1152 (99.67/65.88)	GIEACLAEIDERVRSLLPVPSALPAGMSMAQlqqrRAQAAAHAHQQAQQQQQQQQQQQahQQAQTARMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.03|      42|     845|       4|      48|       8
---------------------------------------------------------------------------
    4-   48 (72.67/46.41)	GGRNGGAHSNHDRdqpTQQMNGASRHAME.GS.........GDVAGRQAEANG.PL
  869-  921 (57.36/29.19)	GGGGGGERREERR...STALSSSVRLRLErGCphlrvvdflGRVAGDAATAEAvPF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26894 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAVASPFGREEEEDSRTDAKEEKIDSKMDAKVDMKADKTD
2) LLPVPSALPAGMSMAQLQQRRAQAAAHAHQQAQQQQQQQQQQQAHQQAQTARMG
3) MENGGRNGGAHSNHDRDQPTQQMNGASRHAMEGSGDVAGRQAEANGPLASVGPPRMNDLPGAI
1038
1099
1
1077
1152
63










Molecular Recognition Features






MoRF SequenceStartStop




NANANA