<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26888

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDVGEYETNTFVVSNIASIAFRVYRPVVSSSPSVYTSSAPDVEKALRNDGHLVFADTRRQCIWCFRLMRRDGSAMGSPAKSELATTMDVGPYKLIAVDDGAFEPISLLKGSGGRPHNTVAVNTPNSSSSAVSAFDSTARSTTGPASQSAGLLPLSQTSNISAAASDLDTHSVHSQAATQPDQKGLLPVSAKVVYNFFISAVLAGLSSAYCAKARAIALNSRTLLLPPLDPLWDGDERSRSDGRALIATLRVTLTTAGSLLLYISHTVLHGMGCSEWACYAGIPPEGCAVLTAPWGKFATVRGVYQPPMPAGMGLKRKQVSATSAPLMWKNFASKMLETRGISPVILQNSSWLRIEFSLSEEAPNDVPVVMLWPSVLCFWSLESPTITTAPSQRLDPLSDIREAYLEETKEDDPAAKLEDMDVPMEDIQMVADDKGKRSVDRQPLSGALNTYNNVSINSAAAAAAAASANSAALGAMYPTPPDGVLNAVGVTPTFDGSTSSPGNMASTTALAYLDGSVPQLGAHDASLGDFWDSGEPKREEQEEPFTAEPDALFGDIGADIFGDDITDADFNFFDEKPDRADAGASSAVSDKMDMVESPQQASPQADQQEPPPTEVPQMEEAVPEEKTPSRPESPVFAKPELKNARSNLPGESQAVKPASNALDTKPVAAGIKRPPSPFDALTVFKRIRATTEDSKSQKVAPKQPFARRGNLFQGLKFSDFMIENNKKYEQNGKFGFRWPHPETDMLSDLSMVTSPTAFRRPTGKQANPSDSSPEWAALITSITRGLKSSSLQAQSFLDDSEDSSSGSSEDALSSEDTDDDDEAMTVSSAPRKPDMSESMPTPEAAAELSRAYSEGVWDVPIARYFVDPMPPPTELAYTDNDVIDVAQILTQQVTRMTIRSGFDEDEARDLQKTKLRNTLLQRIRYSVATLHDVLPAALDEATRCSLKPYLDVQDIPLLVQPARPRQPLGQEQLRPNVFHIPTPHVEIQRHEWTLSLAPTAIDFWDTLALEPLHGSKEIRAVCVYPDFDGLDDEVNGFLNRMRIVYESLRLGSHDRLSEKSGHVTEGMVSFDARVSSGTPSGIATPRPEFAGADQVHRLAQALAAEDAQGKSLVVYFVYCEEVTGAVVDACLAFQRLSQLYEMAVTGCSSEPGDLVLQLIPTSFLASPTALVVPTPADLLRLSLEVYDRCASARGPRPAPAFLLEQPPPRMLDLRLSATPSVDVQRENSCIHVAYARSTDERWMTAAWTDSSGWRQFSSAYWVGRKGRLPATSFAAVAQEIWDNTCAIVGNLKVNWRAIITKCGPMEPEEMEAWTELAKAETRASISVTLVTVDTQPCLELIPPVVMVPPTVLPLLSAATPAPTPQASAVFSPEQSGNPSADANLAAAGADPNAVAEIDGNVALVDVTDNAWGAIASHRLNIAATWIDQRPALVSGYLVKRGGLGRDDAPVVLEVNVIRTEGSPRTYEQLVRELLSSFRGLGTLARARGILDGERDVRPWHIAAAERAAKALCRWM
Length1515
PositionKinase
OrganismGrosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus) (Graphiocladiella clavigera)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Grosmannia.
Aromaticity0.07
Grand average of hydropathy-0.248
Instability index47.66
Isoelectric point4.85
Molecular weight163634.28
Publications
PubMed=21262841

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26888
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     391.12|     148|     855|      78|     528|       1
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  160-  259 (104.80/365.93)	ISAAASDLDTHSVHSqAATQPDQKGLLPVSAkvvynffISAVLAGLSSAYCAKARAIALNSRTLLLP..PLDP....LWdgDERSRSDGRALIATLRVTLTTAGSL...............................................................................................................................................................................
  363-  427 (50.85/86.61)	..........................................................................................................llyishtvlhgmgcsewacyagippegcavltapwgkfatvrgvyqppmpagmglkrkqvsatsaplmwknfaskmletrgispvilqnsswlriefslseeaPndvPVVMLWPSVLCFWSLESPTITT......APSQRLDPLSDireAYLEETKEdDPAAKLE.DMDVPMEDI
 1243- 1406 (235.47/ 0.00)	MTAAWTDSSGWRQFS.SAYWVGRKGRLPATS.......FAAVAQEIWDNTCAIVGNLKVNWRAIITKcgPMEPeemeAW..TELAKAETRASISVTLVTVDTQPCL....................................................................................................eliP...PVVMVPPTVLPLLSAATPAPTPqasavfSPEQSGNPSAD...ANLAAAGA.DPNAVAEiDGNVALVDV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.85|      21|      25|     616|     639|       2
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  596-  628 (28.67/ 8.46)	ESPQQASPqadqqeppptevPQ.MEEA...VPEEKTP
  632-  654 (22.90/12.42)	ESPVFAKP..............eLKNArsnLPGESQA
  754-  773 (30.28/12.44)	.SPTAFRR............PT.GKQA...NPSDSSP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.49|      24|      25|     527|     550|       3
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  527-  550 (44.16/25.25)	LGDFWDS..GEPKREEQEEPFTAEPD
  553-  578 (37.34/20.20)	FGDIGADifGDDITDADFNFFDEKPD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.51|      22|     366|     469|     520|       4
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  475-  496 (42.67/24.54)	AMYPTPPDGVLNAVGVTPTFDG
 1008- 1029 (41.84/ 6.05)	ALEPLHGSKEIRAVCVYPDFDG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.28|      14|      16|     295|     308|       5
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  295-  308 (27.44/19.28)	G.KFATVRGVYQPPM
  313-  327 (18.84/10.32)	GlKRKQVSATSAPLM
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.91|      18|     366|     501|     520|       6
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  501-  520 (28.35/22.29)	PgnMASTTALAYLDG...SVPQL
  868-  888 (30.56/16.82)	P..MPPPTELAYTDNdviDVAQI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.47|      44|     856|      78|     124|       7
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   78-  124 (68.59/48.43)	PAKSELATTMDVGPYklIAVDDGAF..EPISLLKGSGG...RPhNTVAVNTP
  935-  983 (72.88/41.37)	PAALDEATRCSLKPY..LDVQDIPLlvQPARPRQPLGQeqlRP.NVFHIPTP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26888 with Med13 domain of Kingdom Fungi
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