<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26887

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMATDSIPLMLDGAMGGMAASMPVDLEVEDVELFGDPVVDLSMPTHAPPTKQLRKRVDEMRINGCCQKIAWSRQGTIASIAPDGQAIELRYLRTNPLDGSWGLSEPTPCSQFGTSPQFSGGPVVHLAWAATGSPELAVIDAAGRVSILTFSMTLNRPYSLRQWDDDPIDDLHAIVGTYWLPLIPQKQSSTFVPAFGPYHPNPAKSALLCVTTSCVLKLFFSQNNNKVQDTSLELESATSSDDLATHASICSEKGGMLLIALVTASRQLKVVRAAIHWASSHQDKQVPPQSIPLNPTMQHRSAAVTTWLQHGAGESQVDISSDQISHLEILPSALVSSNSFAPPLVLTVRSYLPSMTSPFHEQVQSIIDRWELVVDSPAQALHVAFEQVGTKAPPSGTTQPITRLRKLEPIVLDKVIISIHMMQLGKVICIAFSDGTVQYRDRLTMEEIYNETNLSRIMTLSQANFQFANPTPCVAVAFSPTNCSFSQVCEDGKVKWNSLKHVGPDLGPGHKDAEYAAVVAGLTIAVSTASLNQMSYDDVLATARQFVDKPRFAYDWMVDVVRMLKINVDYSEESHHDQLMRNHSLQLCLSILNHMGFRGEYQPRTFCGKFAMLSLNVRNIVILITIASNTPSTFKEKLNPLDEPEVVDALAGCAKWALDLLAYIADCIFNLLDDAKFMQMLSTSSFQEMTAYLQEKNEVALHLLLCSSTRGFLSAACRRLVHLDAVSTKATQYYELQSQMAASGNGTEHATRPVLVPLSLAYQKMQQYTSSSLVKVTEFDKLLMGLGEDIRQTYQSRTMGQAQAQAQAQGQGQGQGQGQGQVQVQQDANMKRLQAHCELALLLANNPPQSFQPMLKKFFSENVRAFRAMTDPAKLYFANYSILEVEDDVRALQAKRARHCYIDVFKRVELAGPPRLDGGGTSELMPPMGMHGPTGLWRRCARCTAVMEDLSGHKPGYTFVLSQQHAWENLTIRINRSGTMFTGLVEEIGEVSVLNRQDETGGTSLTIALPAGSELLSDAHLGDSIAINGCCLTVTELVAGRTAFVVGVAPETLRVTNLGDLAVGGRVNLERAVRADTRMGGHFVQGHVDTVAQITRVAPDGNAQTMRFSLRDRAALQHIVYKGFIAIDGTSLTVTAVDDAAGWLEVMLITYTQSRVALAAKREGDSVNIEVDVLSKYAQKNISVYIDSLVGGSGIESLVQRKIESALDAAKT
Length1211
PositionTail
OrganismGrosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus) (Graphiocladiella clavigera)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Grosmannia.
Aromaticity0.07
Grand average of hydropathy-0.079
Instability index39.39
Isoelectric point5.89
Molecular weight132361.75
Publications
PubMed=21262841

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26887
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     307.18|     104|     373|      65|     179|       1
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   65-  179 (168.25/128.66)	CqkIAWSrQGTIAsiAPDGQAIELRYLRTN.....PL.DGSWGLSEPTPCSQFGTSP...QFS....GGPVvhlAWAATG..SPELAV..IDA..AGRVSILTfsMTLNRPySLRQWD.DDPIDDLHAIVG....TY.WL
  428-  556 (138.93/79.64)	C..IAFS.DGTVQ..YRDRLTMEEIYNETNlsrimTLsQANFQFANPTPCVAVAFSPtncSFSqvceDGKV...KWNSLKhvGPDLGPghKDAeyAAVVAGLT..IAVSTA.SLNQMSyDDVLATARQFVDkprfAYdWM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.58|      29|      32|     704|     732|       2
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  704-  732 (49.67/29.18)	LCSSTRGFLSAACRRLVHLDAVSTKATQY
  739-  767 (50.91/30.07)	MAASGNGTEHATRPVLVPLSLAYQKMQQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     277.48|      92|      99|     975|    1072|       3
---------------------------------------------------------------------------
  975- 1072 (134.57/129.90)	RSGTMFT.GLVEEIGEVSvlnRQDETGGT.SLTIALPAGSELLSDAHLGdSIAINGCCLTVTEL..VAGRTAfVVGVAPETLRVTnLGDLAVGGRVNLERAV
 1077- 1172 (142.91/111.85)	RMGGHFVqGHVDTVAQIT...RVAPDGNAqTMRFSLRDRAALQHIVYKG.FIAIDGTSLTVTAVddAAGWLE.VMLITYTQSRVA.LAAKREGDSVNIEVDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.94|      23|      31|     784|     806|       5
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  784-  806 (39.61/22.68)	GLGEDIRQTYQSRTMGQAQAQAQ
  815-  837 (41.33/23.96)	GQGQGQVQVQQDANMKRLQAHCE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26887 with Med16 domain of Kingdom Fungi
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