<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26885

Description RNA polymerase 2 mediator complex component
SequenceMDPEASLVPGAVPPQSWRAGDLHPHQHQQQQQQLLLQNQHQQQLQNQHQQQLQQQQQHQQHQQQHQLRHPQHLPQQQPYQRMGKQLPQKLWLQRQQLRLQQQQSQQKAHRPHQQNLQYQLLQQHERKHRQHHEHHEHREPHEAQSQSSPPAIQSSSSATAQSAAATAAGRSGGASFAISSAHGAVQKSVFRSLHGEADGGEAQTPASTAATPKTVMAAAVTDRDRPQPPLCSSRGRVPFGDCTWMIEAARKDGEGTAATAAAASGSIPSSPAGPSAISSNNGSLRTAVFKRPGAMLYAGSGNSSGTPLPASPSQPTSESVDKSSGGRPKPWRIEVPANIPHYIVPPPGRRFGGLAKTAGTGSSTAAAGRGYGQPVGTAGRSGTAAGRIQKSGTAGGGGISSGTAGPVVRYMDFNPWRGRCTEDRLNDTTVRNGNYDRVQSSQALTAETSTARGAWLPTALRRNNSTPMLAQLLALANALARERSQIAPGSQFKLPPRVTVTDTRRETWLRDLTNAAIPLRKLSRTIPHGLRGRVLLDQCAQKAVPVDRAMWLARCVGAQELRAFKRKGAASVATLAEAELRWLKDWTLTAQLFLDGALAELDLAGGDQEGDQGGRERLQYGARFVRQLYVERLLDHEQFLYWMLSGLRNAVRPPSAVDPTPYFGLWLFVIEAYFDDIMQRRRAACHLAMTLLGRLEQLEHHQLLHPGASSPTLALIQPKKMLQRIVRGHADTFVCQAVWPRCEQLLAKVLAASTNTDSPTSTSTPSDPDTYTYSLRHAVALSLIRRRNAALRPEMSVEMEQAIHMLLPLDDAIRHAVDFAAHFADFVRLDQAEAVPFVVRWCASIHRPGLAKVYVAARLIGELCGNDARLVTDHVLAFLSSDRRDKTEVPKTGQKQNTSANQRRLHVLHDRQHEGNKALYQLVGLLTERGLFVPGNYLALLILQSRPSDPAEIVSNGRPQVRLAAELPVALLDRPTSNLRANTLRRLGYDTAFEADDLNGILQEVEAVLEEQANHEQTDDTTMKDAPTSSLRPHMSFALLARCVEERSRNVKMAVAAWLDGHVVTPIQAAATTSPMALERVNAVQTLIEKTDDLGLLARFLLALTRSPQSLAVLAMCADTTSLHLAAFVALGQARQLYDQVMSRALAATVAVDVGTSTTFQTMLRPGTDLRPLLLALPALADKMLPPSAPGSLVLGVEGQPLRLVARNAAAAAGGSMTQQPTGNDISQRHYEAGPPRWQPACSVD
Length1245
PositionKinase
OrganismGrosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus) (Graphiocladiella clavigera)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Grosmannia.
Aromaticity0.05
Grand average of hydropathy-0.424
Instability index55.52
Isoelectric point9.56
Molecular weight135814.08
Publications
PubMed=21262841

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26885
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     125.57|      15|      15|      35|      49|       1
---------------------------------------------------------------------------
   35-   49 (29.20/12.84)	LLQNQHQQQLQNQHQ
   52-   66 (29.83/13.28)	LQQQQQHQQHQQQHQ
   73-   87 (22.79/ 8.37)	LPQQQPYQRMGKQLP
   91-  104 (22.85/ 8.41)	WLQRQ.QLRLQQQQS
  132-  146 (20.89/ 7.04)	HEHHEHREPHEAQSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     255.87|      53|      65|     271|     323|       2
---------------------------------------------------------------------------
  173-  223 (55.79/26.78)	..G.............ASfAISSAHGAVQKSV.FR...SLH.GEADGGEA.......QTPasTA.ATPKTVMAAAVTDR
  229-  270 (57.43/27.81)	PLC.............SS..........RGRVpFGDCTWMI.EAARKDGE.......GT......AATAAAASGSIPSS
  271-  323 (93.03/49.99)	PAG.............PS.AISSNNGSLRTAV.FKRPGAML.YAGSGNSS.......GTP..LP.ASPSQPTSESVDKS
  324-  391 (49.62/22.94)	SGGrpkpwrievpaniPH.YIVPPPG........RRFGGLAkTAGTGSSTaaagrgyGQP..VGtAGRSGTAAGRIQKS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.41|      33|      73|    1016|    1048|       3
---------------------------------------------------------------------------
 1016- 1048 (58.73/37.45)	EQTDDTTMKDAPTSSL.RPHMSFALLARCVEERS
 1089- 1122 (50.68/31.22)	EKTDDLGLLARFLLALtRSPQSLAVLAMCADTTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     309.28|     100|     261|     467|     582|       4
---------------------------------------------------------------------------
  467-  582 (141.65/128.73)	PMLAQLlaLANALARERSQIAPGSqfklpprvTVTDTRRETWLRDLTNaAIPLrKLSRTIPHGLRGR..VLLDQCAQKAVPVDRAMWLARCVGAQeLRAFKRKGAASVATLAeaeLRW
  740-  841 (167.62/106.07)	PRCEQL..LAKVLAASTNTDSPTS........TSTPSDPDTYTYSLRH.AVAL.SLIRRRNAALRPEmsVEMEQAIHMLLPLDDAIRHAVDFAAH.FADFVRLDQAEAVPFV...VRW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     283.68|      95|     277|     590|     694|       5
---------------------------------------------------------------------------
  590-  694 (147.06/115.50)	AQLFLDGALAELDLAGGDQ.EGDQGGRErlQYGARFVRQLYV..ERllDHE..QFLYwMLSGLrnaVRPPSAVDPTPYfgLWLFVIEAYFDD....IMQRR...RAACHLAMTLLGR
  868-  974 (136.63/80.30)	ARLVTDHVLAFLSSDRRDKtEVPKTGQK..QNTSANQRRLHVlhDR..QHEgnKALY.QLVGL...LTERGLFVPGNY..LALLILQSRPSDpaeiVSNGRpqvRLAAELPVALLDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.96|      26|     701|     435|     461|       6
---------------------------------------------------------------------------
  435-  461 (41.71/28.21)	YDRVQsSQALTAETSTARGA..WLPTALR
 1138- 1165 (40.25/22.62)	YDQVM.SRALAATVAVDVGTstTFQTMLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.80|      30|     839|     394|     423|       8
---------------------------------------------------------------------------
  394-  423 (58.26/32.30)	AGGGGISSGTAGPVV.RYMDFNP..WRGRCTED
 1213- 1245 (49.54/26.35)	AGGSMTQQPTGNDISqRHYEAGPprWQPACSVD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26885 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGGSMTQQPTGNDISQRHYEAGPPRWQPACSVD
2) CTWMIEAARKDGEGTAATAAAASGSIPSSPAGPSAISSNNGSLR
3) GAVQKSVFRSLHGEADGGEAQTPASTAATPKTVMAAAVTDRDRPQPPLCSSRGR
4) MDPEASLVPGAVPPQSWRAGDLHPHQHQQQQQQLLLQNQHQQQLQNQHQQQLQQQQQHQQHQQQHQLRHPQHLPQQQPYQRMGKQLPQKLWLQRQQLRLQQQQSQQKAHRPHQQNLQYQLLQQHERKHRQHHEHHEHREPHEAQSQSSPPAIQSSSSATAQSAAATAAGRSGGASFAISSA
5) VFKRPGAMLYAGSGNSSGTPLPASPSQPTSESVDKSSGGRPKPWRIEVPANIPHYIVPPPGRRFGGLAKTAGTGSSTAAAGRGYGQPVGTAGRSGTAAGRIQKSGTAGGGGISSGTA
1213
242
183
1
288
1245
285
236
181
404










Molecular Recognition Features






MoRF SequenceStartStop




1) PWRIEVPANIPHY
330
342