<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26875

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPAGALTNFRVLDGFFHIFWRIYSRVAPKSRGSQFDLLESSGLRNSNEVRSALLALRNDGCYVSQLANRSELWIFSPNPNFEALVQDSGNGKSDEDLIVAGKATFLNVASGVNTAAEVKHCLLSDPDSSIFESAATQNKLTTNCSEYAQLKSLTTYSAFYEGFISAISKALTLHFTKQQKVIPLGTRTLYSSLEENGYQSGDDDLPFSRKSTSFLSILDINVTSKGRLAISLCTLPQPGLEQLLRDSESEIIDARLSDDVWIAPSGTLCRLTSTGEYQSTQSNIVSPGHIATTPHEVEPLASKMKADKREWKRCVAEWLRIFGLQLNDPEAELWVEVEVNALDRQLYILFSKSNWNHQKSSPFIRILWPLKLCFTRSRSKMTGPANPTEFFSGQAESPLQLAERWVKEPCPIRQPFDKHKTSDDPSELEKQQQKCSEPSPLKLDHPEMPESLARVINLPEAQLASAVYPTPPGGGLAQGMGAGIVSEGLGTSAIDTLNYPPTQSEQIYNETVGPAAYFRGTSELLPTGLDPTTSELGIGSGLYDTAADEDFFGDMDVANFDTKGITEADFNFFDEPEFTGLTGDLDMQTSEPDAVQHDTEANFTAPDSADTAMSITEPSPSNYDQNHLTRSEHDTIKQPAFSSLITTGDEDHICKETTELSQIISTDDSQKKRPISPPLSPVQIKKILSPDVSTNLRLTPFKSDISRLRIAPNQYSPVIFQPRLCSSDQKYKIDGKFWFTPGKRYITSNLGGSPSGIPTIGFPEKGRKVRPKPLPILTSLHPLISDNTLEIELQSPSTSSSGSSEGNSDTDHESNASSSHVMNFHPKRNRDYEVEGNSTPSPLDILTQTSDLDKGPLSEHQFALLGAFLSEGVDWPLTGYFSRKQNDIFPVFLRREDLLQTAQLVVDQITQSSFCHIRDDLHKPEWADWDDILSRSLFDNIDGLGHLSKLDLRTYVTLEDGSNPRKDGPSIRPNLTGSICKICPPHIKVHRGNSYLEILPSAIGFWETFGLEPLQGEKDIIPFCIYPPNVIEAAEAFIERLGLVYSSGNFGSHSRSNKANGLVPWSLNAASDQNYASLMHALNVSCENLGSSLSNLSVTDKNVVIYIINPFIYDAAIVDICSAFLRLFHKYVGDIDRQHTRHLSELVLQIIPLEFIASADSLVVPTQTDYLRLALEVYSRCPPKDRSSDWLGCSPPLVLADPAPKVVPFRLAAESVAPLEEAKSLHVAYSQSVDQRWVTAAWTDNSGRHQSALSYCLRERDSSVSRPISEIRTQIWATSKDIMDMSLSHWRLIVVKDEPVDLEEVEMWTSLLDQYNRTKAIKVELGIISVNTKPGLSLKLPSSPLQPSALSQQAAQNGPSTTPGSTPRPVPSPDPSGPAATPPTANAPTYTDQHTPPQHAQQPSPDSDQDTILIDKSDETWGVTLSHRLNNSYYLTKHQPALASGYLFRRSGVSDTDGQAIMAVNIIYTNSRRPIDHILKDILRMYRELITLARVRGIVHAQGNSPLPWHIMTAIKGQEMLCYTL
Length1527
PositionKinase
OrganismAjellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma capsulatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
Aromaticity0.08
Grand average of hydropathy-0.375
Instability index51.37
Isoelectric point5.23
Molecular weight168915.76
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26875
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.80|      14|      15|     971|     984|       1
---------------------------------------------------------------------------
  971-  984 (25.35/16.72)	PSIRPNLTGSICKI
  987- 1000 (25.45/16.81)	PHIKVHRGNSYLEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     246.48|     103|     261|     442|     565|       2
---------------------------------------------------------------------------
  442-  476 (19.03/28.04)	..........................................................................................PLKL.....DHPEMPESlARVINLPEAQLASAVyPTPPGG
  494-  565 (98.79/51.56)	SAIDTLNYPPTQ.SEQIYNETV..GPAAY.FRGTSELLPtGLDPTTSELGIGSGLYDTAADEDfFGDMDVANFDTK......................................................
  705-  755 (46.45/14.26)	SDISRLRIAPNQySPVIFQPRLcsSDQKYkIDGKFWFTP.GKRYITSNLG.GS.............................................................................
  798-  881 (82.20/32.77)	...........................................PSTSSSGSSEGNSDTDHESN.ASSSHVMNFHPKrnrdyevegnstpsPLDIltqtsDLDKGPLS.EHQFALLGAFLSEGV.DWPLTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.02|      28|     261|     638|     667|       5
---------------------------------------------------------------------------
  577-  602 (40.01/22.96)	..EPEFTGL..TGDLDMQTSEPDAVQHDTE
  617-  633 (30.28/15.48)	ITEPSPSNY....DQNHLTR.........S
  638-  667 (42.73/31.31)	IKQPAFSSLitTGDEDHICKETTELSQIIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.96|      26|     978|     251|     279|       7
---------------------------------------------------------------------------
  251-  279 (40.73/26.30)	SEIIDARLSDDVWIAPSGtlcRLTSTGEY
 1232- 1257 (48.24/23.76)	SQSVDQRWVTAAWTDNSG...RHQSALSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.35|      50|      85|    1022|    1074|       8
---------------------------------------------------------------------------
 1022- 1074 (76.94/64.17)	IIPFcIYPPNVIEAAEAFIeRLGLVYSsGNFG.SHSR..SNKANGLVPWSLNAASD
 1110- 1162 (79.41/51.38)	INPF.IYDAAIVDICSAFL.RLFHKYV.GDIDrQHTRhlSELVLQIIPLEFIASAD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26875 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IRQPFDKHKTSDDPSELEKQQQKCSEPSPLKLDHPEMPESLARV
2) LSLKLPSSPLQPSALSQQAAQNGPSTTPGSTPRPVPSPDPSGPAATPPTANAPTYTDQHTPPQHAQQPSPDSDQDTILIDKS
3) PEFTGLTGDLDMQTSEPDAVQHDTEANFTAPDSADTAMSITEPSPSNYDQNHLTRSEHDTI
4) TLEIELQSPSTSSSGSSEGNSDTDHESNASSSHVMNFHPKRNRDYEVEGNSTPSPLDILTQTS
414
1338
578
790
457
1419
638
852










Molecular Recognition Features






MoRF SequenceStartStop




NANANA