<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26872

Description RNA polymerase II mediator complex component Srb8
SequenceMIPHPSSHRPPSRPSAPSRRSSAHLYPASDPYPAIDSRPHQNTVIDLTESDHSGAADGERPAKRPRLDAGNGPSQSLEDPLQNQHQQHHQSQNQSSSQHHGSSTASEAPESSMNPLDIMNASSTEQTARPPWSFRSDIRRTGPGAQTELAQWSQSASLPPLPIRPWKYGIQGRHVAGATNQKDNEECGEVTTTPYRIDVPSIAPRFADNKPADFTPWRGSHPEDVLSEQTIKQGFYDRSPAPPTESTSARTSVYPHFKRRSGLKLLSSVFAAALEKRQALCTITAASTFRPPPRVTLTDIKREAWLRDLANPSVPLRRLSRTIPHGIRGKLLLDQCLGKSIPICRAIWLAKCVGANELRAFKRKGTSAGVASGLETKWVRDWTISVQQFIEGVIASFGDASWKLRISYSIRLSARLFLEHLIEQDHFLDWFLTSLDNSSFESLPVWLLMVGVYWQNIVRYRKRAKRLAECLLEKLRLVSDAGQNAHLNPLAQRLSRLTKTLTLYHPSSFILPRTWAKYESVLSSCLDMNLADDKAAFQNLKARNTRVCRLQNDRGKPIQSINQRLIQLLDSSSDVSTICSECLNISQDYSILVTKLIEWASTSFRYGTARTYTVVRVFRKWKRSGVDIDSHILSFLIQDHRKSGVRFFDVYHVICELHVSADIGLLGHLPPHRLPSHIWNLRNTLLSRTGFSVALENATIQLIKASVRRRLPHMFPMLSIDGDAEMTDDVDLTSLSWTVRSEIGNWIRDQVASHVKNSLKSAIDRDFASEVKTSALTPQEFFEVRYILECLCDFSMLADVLKYASGSNNVTVVASAVDTLNYHLDSFNAIGATGDLFKSFTGAYARISKTELSVQDLIASLLDVAIKLPAELSTLSMLRRDQLQRDRKLAMAACSPVSDHIVDTLNTANPTFTEELDQLLTSGNSMDESTLARIFDTLRKKLEAGSVNGEQSAHETARYFANLRPFNTKLFDNLMIKWVISVMRSSPRPKLSSILPPLIGVGCVTLHSFYVLARAFLHSDAHKNAIPDLAELRIDMIQLLDDKLSNGNGSQDLVAYRFKIARQGYMRQYSGEALGLIQDLLADLSENGADTPPKQFKNDLLSTIVTPLFCEVIVRHPSIVGLAAAERTIESINDFSLPLCLINLRLLFSFECDNDVKKRIYDVVFEAAKSNMHKGQPHWIDVVGTLHADAAKEIRQRAEEQLLSLVLSSDSLPASPVSKSGAPTSVTASALVCLRIVEDLSFSVPENGSPSLGPMLIEKMNMVLHRITILESHIMNTNIMQYNDQAAAIRQAHATQESAITFWFYILLRLVSIHRSTFTLGTLSKSDLADQSRLLISITCIALSKTLSPKVPSARPYYIPPTTPLMFAVPPQSSQPQPLFYSTDAGISTNLRTQALDVAATLLDSIPDDSRHQCSRFFRDRCPPFLHPQNNPRLFFLLGPLAADTQPSSSTMQSSQQQPVAPSLSQTTLGPPASTATPAAGAPPGVKSNSSSSQQFQSGNIYNTTNFLPFDDQNSLVGKLRVQHPGGIVGRFPLRPWEMLEESAPVIGVNDTAVDLGWFAARRVRGDVI
Length1569
PositionKinase
OrganismAjellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma capsulatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
Aromaticity0.07
Grand average of hydropathy-0.243
Instability index49.00
Isoelectric point8.76
Molecular weight174231.31
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26872
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.78|      17|      19|     102|     118|       1
---------------------------------------------------------------------------
  102-  118 (29.26/17.98)	SSTASE....A.PESSMNPLDI
  122-  138 (23.00/12.02)	SSTEQT....ArPPWSFRS.DI
  143-  163 (21.51/10.60)	PGAQTElaqwS.QSASLPPLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.45|      21|      21|       5|      25|       2
---------------------------------------------------------------------------
    5-   25 (39.15/21.14)	PSSHRPPSRPSAPSRRSSAHL
   27-   47 (36.30/18.99)	PASDPYPAIDSRPHQNTVIDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.22|      19|      22|     917|     938|       5
---------------------------------------------------------------------------
  920-  938 (32.15/20.70)	LTSGNSMDEST...LARIFDTL
  942-  963 (27.07/ 9.34)	LEAGSVNGEQSaheTARYFANL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.71|      14|      16|     323|     338|       6
---------------------------------------------------------------------------
  323-  338 (21.28/22.42)	IPhgIRGKLLLDQCLG
  341-  354 (28.44/20.09)	IP..ICRAIWLAKCVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.04|      16|      16|     743|     758|       7
---------------------------------------------------------------------------
  739-  754 (27.53/19.22)	VRSEIGNWIRDQVASH
  755-  770 (25.51/17.21)	VKNSLKSAIDRDFASE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.23|      14|      16|     289|     302|       8
---------------------------------------------------------------------------
  289-  302 (25.96/14.70)	FR..PPPRVTLTDIKR
  306-  321 (19.27/ 8.73)	LRdlANPSVPLRRLSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.70|      11|      21|     799|     809|       9
---------------------------------------------------------------------------
  799-  809 (19.56/12.15)	DVLKYASGSNN
  818-  828 (21.14/13.72)	DTLNYHLDSFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.13|      14|      21|     622|     636|      10
---------------------------------------------------------------------------
  622-  636 (20.14/17.68)	KRSGV...DIdSHILSFL
  641-  657 (20.99/12.40)	RKSGVrffDV.YHVICEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.08|      40|     545|     840|     887|      11
---------------------------------------------------------------------------
  840-  887 (53.71/45.16)	FTGAYARISkTELSVQ..DLIASLLDvaiKLPAElstlSMLRRDQLQRDR
 1380- 1421 (68.37/36.79)	FYSTDAGIS.TNLRTQalDVAATLLD...SIPDD....SRHQCSRFFRDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.93|      10|      21|     369|     378|      12
---------------------------------------------------------------------------
  369-  378 (19.32/10.20)	GV.ASGLETKW
  392-  402 (15.61/ 6.93)	GViASFGDASW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.17|      44|     227|    1023|    1070|      13
---------------------------------------------------------------------------
 1023- 1070 (69.92/59.57)	KNAIPDLAEL...RIDM....IQLLDDKLSNGNGSQ..DLVAyrfkIARQGYMRQYS
 1246- 1298 (62.25/42.14)	ENGSPSLGPMlieKMNMvlhrITILESHIMNTNIMQynDQAA....AIRQAHATQES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.58|      37|     545|     965|    1001|      14
---------------------------------------------------------------------------
  965- 1001 (66.35/39.99)	PFNTK..LFDNLMIKWVISVMRSSP.RP.KLSSILPPLIGV
 1509- 1549 (53.23/30.57)	PFDDQnsLVGKLRVQHPGGIVGRFPlRPwEMLEESAPVIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.93|      18|      19|     222|     239|      16
---------------------------------------------------------------------------
  222-  239 (31.77/19.10)	PEDVLSEQT.IKQGFYDRS
  243-  261 (28.17/16.12)	PTESTSARTsVYPHFKRRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.93|      15|      17|     530|     546|      17
---------------------------------------------------------------------------
  530-  546 (19.00/16.87)	LADDKAafQNLKARNTR
  550-  564 (25.92/15.34)	LQNDRG..KPIQSINQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.68|      31|    1366|      60|      99|      18
---------------------------------------------------------------------------
   60-   98 (46.37/37.36)	RPAKRPRLDAgngpsqsLEDPLQNQhQQHHQSQNQSSSQ
 1427- 1457 (57.30/26.34)	HPQNNPRLFF.......LLGPLAAD.TQPSSSTMQSSQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.32|      28|     121|    1343|    1377|      21
---------------------------------------------------------------------------
 1349- 1377 (53.21/45.70)	PKVPS.ARPYYIPP...TTPLMFAvPP....QSSQPQ
 1459- 1494 (38.11/16.12)	PVAPSlSQTTLGPPastATPAAGA.PPgvksNSSSSQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26872 with Med12 domain of Kingdom Fungi
Unable to open file!