<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26866

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIIMDGTSANGPGREIERQHVDDTLSTTASLAPYNNGNHSNGPSHAKDAACPSNPKFDDFLPPELVHITQGFFPLGHLINRATQQCWNDLTDLITELANPQSTATHAAAGPVTTTNGKYTLSPSSAENAQKKLRILEFAQAKRADFIKILVLSQWSRRAADVSRLIDIQAFIRMRYDCYNGAILSIGEMKRDLIRAQTANPDLAMALEVLATGRVAAIQERSFVPPKPLTPKEMLKTLKKINKTIRTRLVLHDQIPRAFTNYVVHDGRVTFKVPAEFEVDLSIAQESHSSQFFFVDIRFLFSPSPPKPAGRLLDELDNRVNAILMHSGLTGCYNLLHNLILSNKITILFHQAVELAREHWLDTLRVEVLHRTLVVQYWINRPGPKSWIEIGVKGGRRKEQTHDGSITESPFLGLRWMRDNKEVESKDIKLDPELLSMETILRSVTALHISFWLQSTYTKLSQGRLYASGALSVGLQTSINEPGNCFLDVQLTKGRSLRVMIEPVSGAIIFRPTPLLLNRYDIDRSFERPIIDDILFRISRLRSTAVIEEVESLATALGWETVNSRDIKNEDLRRIFPSNILRSVLFFRKSWECNYGIAYTCSMDGDNWWVVELRAPSRDKGPFSPQSARMVTGRFGGLPERLNYASFSQLDYALSGMLAIHVNACYLSELHGIHYFPSVRNLSLGPHLQVPSIFIRFRSGSLPSALRISPSITADKNPTVRDTVRLSFRGIHPSSQCAILLAHGNLSREIKDLALLAVHLDPTITFQPNGRGFAMRFLTPVGKPMIIQLLARLQQLEHVISTLDTLKQKSLKLLSVSLSKIKFSYAADEGARAIINFNYHEQSIESDIDSVTLLSKQAPLMLLRMSIDFHQQNPHRRVKESLTSTLNGLRPGARAGAGLEAVLKLLVITRPILQALERISTGSRSNLPGNSGVQITTRSSKIFHLRYPSLRYRFCIHAGLRRDRVVWVLRDMTTMSDKTGREAVELKLKEQIFGASGDGWQGLGNGAIADCEKIGNLVSALHGVLTDYISSETGGGLGMNPLGKRNGGTGTDLDPGSGGSSGGSDDVGL
Length1071
PositionTail
OrganismAjellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma capsulatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
Aromaticity0.07
Grand average of hydropathy-0.181
Instability index45.02
Isoelectric point9.36
Molecular weight118952.11
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26866
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     189.12|      53|     155|     180|     234|       1
---------------------------------------------------------------------------
   88-  132 (68.30/44.44)	CWND..LT.......DLI.TELANPQ.STATHA.AAGPVTTTNgKYTLSPSSAENAQ
  137-  174 (39.01/21.80)	.....ILEFAQAKRaDFIKILVLSQWSRRAADV...SRLIDIQ...AFI........
  180-  234 (81.81/63.76)	CYNGaILSIGEMKR.DLIRAQTANPDLAMALEVlATGRVAAIQ.ERSFVPPKPLTPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.49|      37|      47|     784|     820|       4
---------------------------------------------------------------------------
  784-  820 (59.46/43.86)	GKPMIIQLLARLQQLEHVISTLDTL.KQKSLKLLSVSL
  832-  869 (58.03/42.62)	GARAIINFNYHEQSIESDIDSVTLLsKQAPLMLLRMSI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26866 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MNPLGKRNGGTGTDLDPGSGGSSGGSDDVGL
2) MPGIIMDGTSANGPGREIERQHVDDTLSTTASLAPYNNGNHSNGPSHAKDAACPSN
1041
1
1071
56










Molecular Recognition Features






MoRF SequenceStartStop




NANANA