<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26859
Description |
Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MEGFKFAGSSSGQWKTFLRRCLSERSDAAEFGRFATVMLNRHSIPGRRLIDIILAARVVTNVPWDPLIPLYVDTLHRLGSIKLEDILESLLAHSTVSQKQASVQNGSATKTPLSTLMTDYCVIHNATIAATSGHAPKTIAEAGNTFSALAQWILSLLSSNSSREPEGDPASSLTSSPDALAVFESLGILFAALVSTERSVNALSAAGTKEWRNKLGQALSEYIPLCAGVSIPLRDRLEALQKDFNLYGHDGEKSLEDTMMENVNISALEFESNVLDGVIINSRAGPYIYVNALLVGRPLVDDNMVVNYLNNRYGGDRMALIEDLITAAFDVLSNGMYRNEPNRTMFIFRSFLVNKLPPFFAEMCTSAINPIPMELCITRALSRIDPNAFPSFSEMFAMQGNSILSDVRQEFLFACALHKLIPEASIERLLGENPMQTLPVGGQFRREDLVSQINSNPERAEQLINELESMEGNAGAIAAAITEPLCALLDAWKWGEEQGESQPVYDEFGSILLLILAFKHKYGLSHYDLGISNPDSFVLRLLNHGSSSQRLEDLDEKQKNNLGAWITALFIAEGISDDSMSSCSPQEFYFLVATLFSQSLAACETGKLEFETLKGGFEYLLEPFLLPSLVTALTWLGHHIWESESDLATSLKLLLALVKPSSISGEAQEIHRTVLLITAKPLEDQLKGVRTRHPSRNDIKPVLEALEPYHSFQRRSTARYGEVEGWAANPAGGGIVASIRNTFSSFVFWSTSPEISMTPPSYTHRQIVAGIRLVGAVRVLRGIIDELKLQAETGSGDLALDIAATLICAPLAESFAVERAAFHPVDPSKDSVPHCSILTLRDALSLERESIPKLVNSDTLRAELIVRLNRRVDALAAIPQMSQEVSNIDVGNIMQDINLEEESMGMTNQRHDQGGEQAGQQDQVADDAGDLNDMLDAAVAAAAGGDGAGNEQGIGMSGISGISMTMDSGIDASIDDVLNEADMGAGNPEFLDLDMDGMF |
Length | 999 |
Position | Tail |
Organism | Ajellomyces capsulatus (strain H88) (Darling's disease fungus) (Histoplasma capsulatum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Ajellomycetaceae> Histoplasma.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.048 |
Instability index | 41.21 |
Isoelectric point | 4.73 |
Molecular weight | 108854.16 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364142
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP26859
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 78.25| 22| 26| 946| 967| 1
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946- 967 (39.30/26.17) DGAGNEQGIGMSGISGISMTMD
975- 996 (38.95/25.86) DDVLNEADMGAGNPEFLDLDMD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 44.97| 13| 26| 588| 600| 2
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588- 600 (22.01/12.40) FYFLVATLFSQSL
617- 629 (22.96/13.23) FEYLLEPFLLPSL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 36.64| 12| 26| 808| 819| 3
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808- 819 (21.11/12.64) CA..PLAESFAVER
835- 848 (15.53/ 7.43) CSilTLRDALSLER
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