<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26857

Description Enhancer of polycomb-like protein 1
SequenceMPTPSNAIEINDGSHKSGRSTRRSGSRSAHDDGLDSFSKGDSGAGASAGSSNSRFRHRKISVKQHLKIYLPNDLKHLDKDELQQREVVEIETGVEKNEEKEVHLHRILQMGSGHTKHKDYIPTPDASMTWNEYDKFYTGSFQETTSYIKFSATVEDCCGTNYNMDERDETFLNEQVNKGSSDILTEDEFEILCSSFEHAIHERQPFLSMDPESILSFEELKPTLIKSDMADFNLRNQLNHEINSHKTHFITQFDPVSQMNTRPLIQLIEKFGSKIYDYWRERKIEVNGYEIFPQLKFERPGEKEEIDPYVCFRRREVRHPRKTRRIDILNSQRLRALHQELKNAKDLALLVAKRENVSLNWINDELKIFDQRVKIKNLKRSLNISGEDDDLINHKRKRPTIVTVEQREAELRKAELKRAAAAAAAAKAKNNKRNNQLEDKSSRLTKQQQQQLLQQQQQQQQNALKTENGKQLANASSSSTSQPITSHVYVKLPSSKIPDIVLEDVDALLNSKEKNARKFVQEKMEKRKIEDADVFFNLTDDPFNPVFDMSLPKNFSTSNVPFASIASSKFQIDRSFYSSHLPEYLKGISDDIRIYDSNGRSRNKDNYNLDTKRIKKTELYDPFQENLEIHSREYPIKFRKRVGRSNIKYVDRMPNFTTSSTKSACSLMDFVDFDSIEKEQYSREGSNDTDSINVYDSKYDEFVRLYDKWKYDSPQNEYGIKFSDEPARLNQISNDTQVIRFGTMLGTKSYEQLREATIKYRRDYITRLKQKHIQHLQQQQQQQQQQQQQAQQQKQKSQNNNSNSSNSLKKLNDSLINSEAKQNSSITQKNSS
Length832
PositionTail
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Saccharomyces.
Aromaticity0.08
Grand average of hydropathy-1.022
Instability index56.27
Isoelectric point8.80
Molecular weight96736.69
Publications
PubMed=7670463
PubMed=24374639
PubMed=10911987
PubMed=9735366
PubMed=12782659
PubMed=14690591
PubMed=14562095
PubMed=14562106
PubMed=14966276
PubMed=15485911
PubMed=15045029
PubMed=15353583

Function

Annotated function Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M. 
ECO:0000269	PubMed:10911987
ECO:0000269	PubMed:12782659
ECO:0000269	PubMed:14966276
ECO:0000269	PubMed:15045029
GO - Cellular Component
NuA4 histone acetyltransferase complex	GO:0035267	IDA:SGD
Piccolo NuA4 histone acetyltransferase complex	GO:0032777	IDA:SGD
GO - Biological Function
GO - Biological Process
cell cycle	GO:0007049	IEA:UniProtKB-KW
DNA repair	GO:0006281	IDA:SGD
histone acetylation	GO:0016573	IDA:SGD
positive regulation of macroautophagy	GO:0016239	IMSGD
regulation of transcription by RNA polymerase II	GO:0006357	IDA:SGD









Interaction





Binary Interactions
[P43572<-->P38806: YNG2]	NbExp=10	EBI-22792,EBI-24622












Repeat regions





Repeats

>MDP26857
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     805.52|     276|     337|     145|     481|       1
---------------------------------------------------------------------------
  145-  481 (400.17/396.13)	TS..YIKF.SATVEDCCGTN....YNMDERD.ETFLNEQVNKgsSDILTEDEFeilcssFEHAIHERQPFLSMD.PEsilsfeelkptliksdmaDFNLRNQLNHEINSHKthFitQFDpvSQMNTRPLIQLIEKFGS..KIYDYwRERKIEVNGYeifpQLKFERPGEKEEIDPY.....VCFRRREVRHPRKTRRIDILNSQRLRAL.HQELKNAKDLALLV....AKRENVSLNWIND..ELKIFDQR.....................VKIKNLKRSLNISGEDDDLInhkrKRPTIVTVEQREaELRKAELKraaaaaaaakaknnKRN..NQLEDKSSRLTKQQQQQLLQQQQQQQQNALKTENgkqlaNASSSSTS
  485-  807 (405.35/272.59)	TShvYVKLpSSKIPDIVLEDvdalLNSKEKNaRKFVQEKMEK..RKIEDADVF......FNLTDDPFNPVFDMSlPK..................NFSTSNVPFASIASSK..F..QID..RSFYSSHLPEYLKGISDdiRIYDS.NGRSRNKDNY....NLDTKRIKKTELYDPFqenleIHSREYPIKFRKRVGRSNIKYVDRMPNFtTSSTKSACSLMDFVdfdsIEKEQYSREGSNDtdSINVYDSKydefvrlydkwkydspqneygIKFSDEPARLNQISNDTQVI....RFGTMLGTKSYE.QLREATIK.............yRRDyiTRLKQKHIQHLQQQQQQQQQQQQQAQQQKQKSQN.....NNSNSSNS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26857 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAAAAAAKAKNNKRNNQLEDKSSRLTKQQQQQLLQQQQQQQQNALKTENGKQLANASSSST
2) KQKHIQHLQQQQQQQQQQQQQAQQQKQKSQNNNSNSSNSLKKLNDSLINSEAKQNSSITQKNSS
3) MPTPSNAIEINDGSHKSGRSTRRSGSRSAHDDGLDSFSKGDSGAGASAGSSNSRFRH
419
769
1
480
832
57










Molecular Recognition Features






MoRF SequenceStartStop




1) RKISVKQHLKIYL
58
70