<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26855

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMVPMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLAAFRQFWSGLSQESHEQCVQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDSLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKAILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNGDSTLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRVPLPGTSCLASASVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHTKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSHRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLNDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTDENEIITQFSVQGFPPLFLCLLWKMLLETDHISQIGYKVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQSDWHTKHMSYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMCLRNRDHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKHAMNAREDNPWVPEDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVNVISSSSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEALLPVVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAVPPQALNSGSPAPQSNQVPASLPVTQ
Length1376
PositionTail
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.10
Grand average of hydropathy-0.001
Instability index47.54
Isoelectric point6.92
Molecular weight157053.87
Publications
PubMed=19468303
PubMed=21183079

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26855
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     389.62|      83|     216|     174|     256|       1
---------------------------------------------------------------------------
  174-  256 (142.68/88.47)	LERNACLLPAY.FAVTEIRK.LYPEGK.LPHWLLGNLVSDFVDTFRP.TARINSICGRC.SLLPVVNNSG.....AICNS....WKLDPATLRFPL.K
  257-  303 (43.55/21.41)	..................................GLLPYD.KDLFEPqTALLRYVLEQ.....PY..SRD.....MVCNM....LGLNKQTLNIAQhK
  309-  390 (101.02/60.29)	LEDQLVDLVVYaMERSETEE.KFDDGG.TSQLLWQHLSSQLI..FFV.LFQFASFPHMVlSLHQKLAGRG.....LIKGRdhlmWVL....LQF.I.S
  393-  472 (102.37/61.20)	IQKNA..LADF.LPVMKLFDlLYPEKEcIP.......VPD.INKPQS.THAFAMTCIWI.HLNRKAQNGDstlqiPIPHS....LKLHHEFLQQSL.R
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     215.66|      41|      91|    1072|    1112|       2
---------------------------------------------------------------------------
  908-  937 (41.56/20.80)	...........RVSDFVKENSPE.H..WLQSDW...HTKHMSYHKKY
  938-  972 (38.68/18.85)	PEKLYFEGLAEQVDPPVPIQSPYlPiyFGNVCL...RF.........
 1072- 1112 (76.90/44.81)	PEDSYYCKLIGRLVDTMAGKSPG.P..FPNCDW...RFNEFPNPAAH
 1166- 1206 (58.53/32.33)	PE.PYWIVLHDRIVNVISSSS...L..TSETEWvgyPFRLFDFTACH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.04|      19|      81|     783|     801|       3
---------------------------------------------------------------------------
  783-  801 (34.60/21.04)	NEIITQFSVQGFPPLFLCL
  860-  878 (34.44/20.91)	NDMVWKYNIVTLDRLILCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.35|      55|     262|     980|    1035|       5
---------------------------------------------------------------------------
  980- 1035 (97.23/58.37)	IHRFL..ELLPVSKSLETLL..DHLGG..LYKF.HDRPVTYLYNTLHYYEMCLrNRDHLKRKL
 1236- 1297 (81.12/44.26)	IPKFLteALLPVVKTEFQLLyvYHLVGpfLQRFqQERTRCMIEIGVAFYDMLL.NVDQCSTHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.50|      23|     126|     593|     617|       6
---------------------------------------------------------------------------
  593-  617 (35.18/33.87)	FISQLLPTV..FKSHAWGIlHTlLEMF
  720-  744 (43.32/30.50)	WCKDILQTImnFTPHNWAS.HT.LSCF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.35|      30|     262|     549|     582|       7
---------------------------------------------------------------------------
  549-  582 (43.04/44.36)	IHSIATRVIKLAHTKSSValapALVETYSRLLVY
  812-  841 (50.31/39.15)	ISQIGYKVLERIGARALV....AHVRTFADFLVY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26855 with Med23 domain of Kingdom Metazoa
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