<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26851

Description Mediator complex subunit 14
SequenceMAPVQIGSDGQLVPAGGPTSTPQPPPGAPATQGVRLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQAYLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKAEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQVNYIHELVQSRLFGDDKPLQDMYTCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYIPAKCLTLSVWNQQVLGRKTGTASVHKVTIKIDESDGSKPLQISHEPPLPACDSKLMERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKSSNPNDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGVDQSMLDDIEKSINDDMKRIVTWLLQLKFWLGEQRCRQSVKHLPTLCTDTLHLSNLTTHPVGNLSKHRLFIKLTRLPQYYIVVEMFDVPSNLTELQYKYYFLSVSQMESEDGLPSAQLFRHFKPNLEELVQDISSCRMVRPGTKRKLSGEQSAVEPKKPKRSGEMCAFNKELAHLVAMCDTNMPLIGLRSELSNMEIPHQGVQVEGDGCSHAIRILKVPPCMAVGEETRKALERSLLDCTFRLQGRNNRTWVAELIFSSCPLNSTSIKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWNSISKLYECVLEFSRSLTEMPSYLSLFSEIRLYNYRKLVLCYGSTKGSSVTIQWNSVTHRYHLALGTVGPNSGCSNCHNIILHQLQEMFNKTPNVVQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPISMEDTFMPHTQTQPPGRGVYPPLTSPPNPYHVPPSPSMITTQSPGTLDPSSPYTLVSASPRVGPWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPSHSPRAGTSSQAMPPPRKLPQRSWAASIPTILTHSKLHVLLLPSPMPCPVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQLEPNLTIVNSNEPGVIMFKTEVLKCRVALNPKSYQTLQLKVTPENTGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAAQLNWNVQFCLTIPPSAPPIAPPGTIAVVLKTKMLFFLQLTQRLPVPQEPISIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSSILRRFNEHHPPRPGECTIFAAVHELMANLTLNSGGRP
Length1379
PositionTail
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio.
Aromaticity0.07
Grand average of hydropathy-0.181
Instability index50.58
Isoelectric point8.64
Molecular weight154061.67
Publications
PubMed=23594743

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
blood vessel morphogenesis	GO:0048514	IMZFIN
brain development	GO:0007420	IMZFIN
embryonic viscerocranium morphogenesis	GO:0048703	IMZFIN
neural crest cell differentiation	GO:0014033	IMZFIN
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
stem cell population maintenance	GO:0019827	IMZFIN
ventricular system development	GO:0021591	IMZFIN

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26851
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     351.11|     110|     209|     620|     828|       1
---------------------------------------------------------------------------
  348-  442 (115.32/45.84)	ESDG.SKPLQISHEPPlpaCdSKLMERAMKidhlSVEKLLID.SVHARSHQKLQELKAILK....SSNP.NDNSFIETALPTLV..I.....PILEPCGRSECLHIFVD............................
  476-  546 (72.22/13.74)	.....................................................TWLLQLKFwlgeQRC...RQSVKH..LPTLCtdTLHLSNLTTHPVGNLSKHRLFIK....LTRLpqYYIVVE....MFDVPSNL
  659-  779 (163.57/242.52)	EGDGcSHAIRILKVPP...C.MAVGEETRK....ALERSLLDcTFRLQGRNNRTWVAELIF....SSCPlNSTSIKEQASTRHV..YLTYENPLSEPVGGRKVVEMFLNdwnsISKL..YECVLEfsrsLTEMPSYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     153.08|      27|      27|     969|     995|       2
---------------------------------------------------------------------------
  969-  995 (56.36/28.34)	PP..SP...I...SMEDTFMP...HTQTQPPGRGVYPP
 1006- 1019 (22.64/ 6.44)	PP..SP.......SM..........ITTQSPGT.....
 1022- 1054 (39.42/17.33)	PS..SPytlV...SASPRVGPwpgSPQVSGPSPGARIP
 1061- 1090 (34.65/14.24)	PSlhSP...IpdpSHSPRAGT...SSQAMPPPRKL.P.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     362.94|      98|     280|     799|     901|       3
---------------------------------------------------------------------------
  799-  891 (157.13/85.41)	........................STKGSSVTI.QWNSVTHRYHLA.LGTVGPNS...G..CSNCHNIILHQLQEMFNK...TPNVVQLLQ..VLSDTQAP..........................LNAINKLPTV.PM.LGLTQRTNTAYQCFSI
 1102- 1245 (105.65/61.83)	LTHSKlhvlllpspmpcpvpglagSYLCSPLER.FLGSVIMRRHLQrIIQLEPNL...TivNSNEPGVIMFKTEVLKCRvalNPKSYQTLQlkVTPENTGPwsqeelqvlekffetrvagppfkyntLNAFTKLLGA.P........TNILRDCVRI
 1248- 1329 (100.16/52.48)	LELFP............................dQAAQLNWNVQFC.L.TIPPSAppiA..PPGTIAVVL.KTKMLF........FLQLTQ..RLPVPQEP..........................ISII..VPIVyDMaTGLTQQADIPRQ....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.21|      18|      27|     147|     166|       4
---------------------------------------------------------------------------
  147-  166 (29.48/22.49)	TTgsYPRLPTCIRDKII....PPD
  175-  196 (25.72/12.68)	TT..LNQLNQILRHRLVttdlPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.54|      21|      29|     232|     252|       5
---------------------------------------------------------------------------
  232-  252 (32.76/25.64)	LLKLEILVEDKETGDGRALVH
  262-  282 (37.78/30.94)	LVQSRLFGDDKPLQDMYTCLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.51|      13|      31|      70|      82|       6
---------------------------------------------------------------------------
   70-   82 (22.05/15.20)	IVQFASRTRQLFV
  103-  115 (22.46/15.63)	ISSFLDQQAYLFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.62|      11|      28|     615|     628|       7
---------------------------------------------------------------------------
  615-  628 (12.44/20.89)	RSgEMCafNKELAH
  643-  653 (21.19/13.99)	RS.ELS..NMEIPH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26851 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPISMEDTFMPHTQTQPPGRGVYPPLTSPPNPYHVPPSPSMITTQSPGTLDPSSPYTLVSASPRVGPWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPSHSPRAGTSSQAMPPPRKLPQ
955
1091










Molecular Recognition Features






MoRF SequenceStartStop




NANANA