<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26833

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMVPAGQGGGGGGPGGSISLTVLIDFIIQRTYHELSVLAELLPRKTDMERKIEIYQFASRTRQLFVRLLALVKWAASVSKVDKSANIMAFLDKQSMIFIETADALSRMARETLVHARLPNFHLPAAVEVLTLGTYSRLPLVIRDKIIPPDPITAVEKKNTLSRLSQVIEYRLATTTLPTQMRKNRIENGRVKFTVDHEFEATLTLMGDGPNVPWSLLDINILVEDKETGDGKSLVHQFQVQFIHELLQSRLRDCDNPLLELYTVLHTFSQSLQLEVLHSQTKRLCQERLGELIRVEEYVTGRSLTISYWKDLASRELKSDLGYRVTAQVCTSHSGGSEVIGKPLQILHNPPLSTKDSEMAEQSIRSDHLSLEKLLTHTIYMRTRTRLSELKVELQPKLGHQQTDCVVQGSPPVLHLPILSPCLRSEQLLITVDTRTGSLQAHIPQDDPPAPLMNELQNTLNGDKSRFEAAIGELRFWITQRRCQKTLQHLPVSVYDKLPIMFAADSPMTRLSKHKFFLRLHKHPNSWIVVEFKEKAKDIDYVCHLVIVKPVPIEEMNELDMFLLTHGPCTAIETQEVAVTNKRKREGGALEVARDSTPGPCKRSKHPAYLLPDLSHVVALCDERIPFASLASQLTKRDILHQGLTVEALGAGLSLKLVSLPPVEGVSREAFNDLNRRMLTATIRMQVKGSRAWMLEFLFHGSPLVSVSPTEQGSRFPVYLSYDVTTAEDAGRTVDAILQDWAHIANLYASVLSLASVMQTREERQHFSVKSYNFKKLVLGYGPARMATAAVTWKSHERRFHLGLGCSGQLGSNPHSPLREQLEFFLNKERSCGYLARVLHETYEPLASIAKLPSTLQVGLLSTKPPIPVQTFTVMAHSPTHIRLAYCNLYCLDIHLQSDGQVSIRDGAFSVFDKSKVIEEFGPTQGLKAFLSKYVDEAALSRRRSQSEDDHPPSPIMEHTNEPSHFLGHSRSSGAAGASPAGQQRGDLAGLRFQTPLTPSGTSNPHTPASPHMGNITQTFNPSPSMLPHPSPVGPGSAFGIASSPLPNPLHAPSPAGMLPTPSPNPAGMGGGCHNIESSPFPPQSLASPAPNNWPGSPGMPRPSPARPGGPPSAAASHHSPHGGPSGSAGGGFGGSFVSRVLPQRSWAGAVPTILTHEAFDVLCTPSEMDETFSAGSMMAPLERFLGCISMRRSLQRIIQDSQDCPSALPITEPGVIAFRCESLHGRVTVNPMHMQSLILKLSPSGPEYREQWALEELQVLERFFEVRVMAIPFKPMAIHAFCRLLNASHHILRDLVQLMKLELMPNAFGQQTFKWSVQFCLTVPPSAPSIVPVGASSVLTARNKMLFFLYIRRLGMLPEAEGASLVLPLVYDSINNVTQLAERRDPAAGNMGGLGPVTNTASVMLKRFGECSHMMGLQPGECSIYLAVRYLLANLTLPNEPPAMAVGAGNPVELQQQQQQQQQQPNQMVPMGLGSGPGMANMGPGTPINPMQMQAGPMSMGGGLPQQVQTQGQVSMPIHSPYGQAPMSANPMTPVMGMPINNTIGPAMGQGGPGNMQMQ
Length1559
PositionTail
OrganismDaphnia pulex (Water flea)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Crustacea> Branchiopoda> Diplostraca> Cladocera> Anomopoda> Daphniidae> Daphnia.
Aromaticity0.06
Grand average of hydropathy-0.194
Instability index56.22
Isoelectric point8.37
Molecular weight170877.86
Publications
PubMed=21292972

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP26833
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.99|      25|      29|    1021|    1049|       1
---------------------------------------------------------------------------
 1021- 1039 (34.56/ 9.61)	..........PSPS.MLPHPSPVGPGSAFG
 1042- 1071 (42.32/18.62)	SSPLPNplhaPSPAgMLPTPSPNPAGMGGG
 1086- 1112 (45.11/13.39)	ASPAPN.nwpGSPG.M.PRPSPARPGGPPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     134.55|      26|      29|    1470|    1496|       2
---------------------------------------------------------------------------
 1451- 1469 (28.66/ 9.91)	PVEL....QQQQQQQQQQPN........QMV
 1470- 1496 (52.43/28.22)	PMGL....GSGPGMANMGPGTPiNPMQMQAG
 1497- 1512 (30.21/10.86)	PMS.............MGGGLP.QQVQTQ.G
 1536- 1559 (23.25/ 6.58)	.MGMpinnTIGPAMGQGGPGN....MQMQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.45|      29|      29|     235|     263|       3
---------------------------------------------------------------------------
  235-  263 (52.59/39.31)	HQFQVQFIHELLQSRL.RDCDNPLLELYTV
  265-  294 (45.86/33.15)	HTFSQSLQLEVLHSQTkRLCQERLGELIRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.47|      17|      25|     123|     145|       5
---------------------------------------------------------------------------
  123-  141 (26.07/31.19)	P.AAVEvlTLGTYSRLPLVI
  150-  167 (25.40/10.71)	PiTAVE..KKNTLSRLSQVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.35|      16|      22|    1391|    1408|       6
---------------------------------------------------------------------------
 1391- 1408 (25.46/18.63)	MGGLGPvtNTASVMLK.RF
 1414- 1430 (27.90/14.33)	MMGLQP..GECSIYLAvRY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.06|      12|      22|     769|     781|       7
---------------------------------------------------------------------------
  769-  781 (17.26/16.01)	KSYNfKKLVLGYG
  793-  804 (22.80/14.78)	KSHE.RRFHLGLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.24|      38|      43|    1163|    1205|       8
---------------------------------------------------------------------------
  356-  404 (48.86/29.62)	SEMAEQ.SIRSDHLSLEKLLtHTIYMRtRTrlselkveLQpKLGHQQTDC
 1166- 1204 (66.38/54.09)	SEMDETfSAGSMMAPLERFL.GCISMR.RS........LQ.RIIQDSQDC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.55|      38|      43|    1227|    1264|       9
---------------------------------------------------------------------------
 1227- 1264 (65.47/42.07)	VTVNPMHMQSLILKLSPSGPEYREQWALEELQVLERFF
 1271- 1308 (66.08/42.53)	IPFKPMAIHAFCRLLNASHHILRDLVQLMKLELMPNAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.73|      12|      44|     656|     667|      10
---------------------------------------------------------------------------
  656-  667 (21.97/11.98)	LVSLPPVEGVSR
  703-  714 (21.76/11.79)	LVSVSPTEQGSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.73|      19|      25|     972|     994|      11
---------------------------------------------------------------------------
  972-  994 (27.74/24.02)	SGAAGA.SPAGQQRGDLAglrfQT
  999- 1018 (31.99/16.68)	SGTSNPhTPASPHMGNIT....QT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.26|      18|      43|     298|     315|      12
---------------------------------------------------------------------------
  298-  315 (30.71/17.92)	VTGRSLTISYWKDLASRE
  338-  355 (31.55/18.62)	VIGKPLQILHNPPLSTKD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26833 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALSRRRSQSEDDHPPSPIMEHTNEPSHFLGHSRSSGAAGASPAGQQRGDLAGLRFQTPLTPSGTSNPHTPASPHMGNITQTFNPSPSMLPHPSPVGPGSAFGIASSPLPNPLHAPSPAGMLPTPSPNPAGMGGGCHNIESSPFPPQSLASPAPNNWPGSPGMPRPSPARPGGPPSAAASHHSPHGGPSGSAGGGFGG
2) PAMAVGAGNPVELQQQQQQQQQQPNQMVPMGLGSGPGMANMGPGTPINPMQMQAGPMSMGGGLPQQVQTQGQVSMPIHSPYGQAPMSANPMTPVMGMPINNTIGPAMGQGGPGNMQMQ
938
1442
1134
1559










Molecular Recognition Features






MoRF SequenceStartStop




NANANA