<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26827

Description Uncharacterized protein
SequenceMENRPLKKLRLGPPDVYPQDPKQKEDELTPVNVKQGFSHTPNLNQSEEYGSAKNHNFSLSKVQTFINGVLTKKQEINTLPDTGRKRQLINPKENFHNVTPKSKAFIESWFKDLAGSKPLMNLGKRVPIFNKKEEIFIQLSEYQVPMSRAIWLIKMTSAYSVAISEAKMKKRQVPDSSQEWTSTLVRFIKEQIVKLQDFYQKSTNSGGTSAAYASNATAYHNGSPLMSDEQKLALRQFNYCQQLCKVMFEEGLLECQDFLQWQLDMLEKCKTCDDGLLKFIIPLILQYVDEFTQCEILSRKLVFQVCRRISPLLSNDQISEGSVSLDVGNCGQHRSVIIQMSAIIQAVVLHCPTALVWNHSGEGKISSHLVGSPLDHLPIPPSALPMAPRFSNDHVRQMLREAENAIKQRSKAAESRWPLDKLIHHSEINCSTGIITARVLHALEALDLHSFDRVDLTNSIDSLYVKIFPAIGGNKGNVDPATVEQIGQFAKQDEPFVRLLCQWAVSDQRYGEHRAIAAALLLEKRQMDLVALTESDAVGSEDNDTDENLAAVSAVQPVYQGFLMKFLDSEAPVLNESSSGHNNRTVFASLVHLYYELIKHDVFSHDMYMCTLISRGDLLSVTPGHSGATVAPSTSGHFAGTPSSGMSSLTGFQCMNDLRCEMDDSKIDDDLGKLLQHIKEEQQIVMDTPDSPKDESHNTLEPGRGEKEGKRQSRHLLFTTHFPLPQDDSLIHDCNQRHILLYGVGKAREESRHAVKKVSKEMCRLFHKKLAIDVQTEGTNLAGGVGAFVGSSKSRKHSSRLEFNFELSMQRFLSLSYFDRHAVAAQAASTCMEMINSFTVGGAAYLPILEHISFLFDLFEVSLSISGLIDLCLQLLKELPEVELLLSQRNSVLSRNYLTNVGLYIVGVLRRFHCCLLLSPESTAAAFESLCRIVKHVTNPADCSSAERCILAYLYDLYSCCSFLKVTFYEVFAFSNAYPKIKQTIFAPVVSLPKSVHPLNRDFLQDYITSPRRKPEPHILRQLSDSAQLRYSFVFNVVVAVCNEADNDKLNDIALLCAELTAGCSALSAEWLGVLTSLCYSATAYIDVSTQVDVQDNSIHHNLAVLFSVLLARHCFGLQDFLLYVGVPSLVKIWNEGGRSDTDPEAEAGARLTCHLVLRLFKTSDAPHPACYSNSSHSVNASPHHTLQQTAPSSLGVKLACDRHLLAATHNSISVGPVLAVLKAILVLADRVPPEGSGSNINSSNRLGVGNSSMANEVSISHILGTSWSGDLDLDFGSSNFGVGGGRNSFGGATENVPLASYARYVLRQICSQPWVHQRCLQNPEELLKLDGLLDSCLSLRQAQRLLQMISRPDSGASVVVNRVLESLDQWRLRVAWLDLQLLCQQLTSIGSGGASSTDMNQLLEAIARAVLDVFELSTTPAATPSSSVSGSAIKSHPSLSISLIAPLVSKLPGTVQGRILKVASQVLESCNWGLVSKGKDKERNIPNPTLAFRSKSLLSYEPLLSLVMTCLKGQDEQREMFLSSLHSQLSHFNFLPKEDRLYQGEDIRARQAMLEALQLRFSLVGGLFDSILRNPMVAIDWAILLTQLVTNGVVDASNNTELFTTLQDMLATLLHSTLVTDGQSDRGEDSRKYYPILIKKLKKELAERKGSPSIQCIKQLLPLPKLTSEFVTCEPYGTLTDTKGNKISGFDSNDKKQGHRLYEKQRVSPWEILEGHKTAAPLSWAWFGAVRVERKPLRHQEVQRLLRHHTHALHKPASYYLEHPILPPEELEPPVVEKIVPKEEVCFKMEIPSSDQSPRGVTKRGQKTNQRRPRGRRGAAAAAAAAAAAATVSQPTVGGGYQSPVASGMYPPQPPPQWNNYTAPAPPASQQGTVPTPAAFFPQQTIGPRFPSERPGTQSRQALSNMLRQRHTSTQFVPGSGANPAGANPAAVPSAPPTGAGGGAMPNNPRQQFMRQQMRQQHTGGNVFGQQGPQQAQPQQQQQQQQQQQQQQQQQQQQQQQVQMAPGGFSNIHTPMNQNFGMFQSGTPGMQQLVNPQQQQAQSQPAQQQPQQQGMMGQHFPQGAGNFPMQQTQPQGNMILMQQQHQQPQGRGMNATPMRPPFMQSAGMQMNAAQPNQFVRGAMPNQQQAVRLQHQQMVAIQQQQQMQHNMGQQQQHNQHYHQPF
Length2165
PositionKinase
OrganismDaphnia pulex (Water flea)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Crustacea> Branchiopoda> Diplostraca> Cladocera> Anomopoda> Daphniidae> Daphnia.
Aromaticity0.07
Grand average of hydropathy-0.348
Instability index50.94
Isoelectric point8.11
Molecular weight239980.40
Publications
PubMed=21292972

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26827
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     506.62|      94|      98|    1965|    2061|       1
---------------------------------------------------------------------------
 1799- 1882 (105.14/41.51)	................PRGVTKRGQKTNQRRPRGRRGAAAAAAAAAAAATVSQPTVG..GGYQSPvASGMY.PPQPPPQWNNYTAPA.PPA...SQQGTVptpAAFF
 1883- 1959 (116.48/47.38)	P.....QQtiGPR..FP.SERPGTQSRQALSNMLRQRHTSTQFVPGSGANPAGA...NPAAVPSA..........PPTGAGGGAMP..NNP...RQQ.FM...RQQM
 1965- 2061 (168.66/78.71)	GGNVFgQQ..GPQqaQPQQQQQQQQQQQQQQQQQQQQQQQVQMAPGGFSNIHTPMNQNFGMFQSG.TPGMQ.QLVNPQQQQAQSQPAQQQP...QQQGMM...GQHF
 2064- 2140 (116.34/47.31)	GAGNF...........PM..QQTQPQGNMILMQQQHQQPQ......GRGMNATPMRPPF..MQSA...GMQmNAAQPNQFVRGAMPNQQQAvrlQHQQMV...A...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.58|      23|      87|     333|     355|       3
---------------------------------------------------------------------------
  333-  355 (41.43/26.85)	HRSVIIQMSAIIQAVVLHCPTAL
  424-  446 (41.14/26.61)	HHSEINCSTGIITARVLHALEAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.35|      19|      87|     223|     242|       4
---------------------------------------------------------------------------
  223-  242 (31.69/23.68)	SPLMSDEQ....KLALRQFNyCQQ
  310-  332 (29.66/16.26)	SPLLSNDQisegSVSLDVGN.CGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.14|      17|      87|     705|     738|       5
---------------------------------------------------------------------------
  705-  721 (31.50/14.71)	GEKEGKRQS..RHLLFTTH
 1192- 1210 (23.64/21.24)	PSSLGVKLAcdRHLLAATH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     102.73|      26|      87|    1351|    1376|       7
---------------------------------------------------------------------------
 1351- 1372 (31.27/17.87)	........................SRPDSG..ASVVVNRV..LESLDQWR
 1373- 1411 (23.96/11.69)	LRVA.........wldlqllcqqlTSIGSGgaSSTDMNQL..LEAIARAV
 1412- 1459 (22.25/10.24)	LDVFelsttpaatpsssvsgsaikSHPSLS..ISLIAPLVskLPGTVQGR
 1461- 1474 (25.24/12.77)	LKVA.................................SQV..LES.CNWG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.15|      60|     451|     771|     842|      10
---------------------------------------------------------------------------
  771-  842 (81.91/83.22)	AIDVqtegtnLAGGVGAfVGSSKSRKHSSRLEFNfELSMQRFLSLSyfdrHAV.AAQAASTCMEMINS.FTVGG
 1224- 1285 (96.24/60.91)	AILV......LADRVPP.EGSGSNINSSNRLGVG.NSSMANEVSIS....HILgTSWSGDLDLDFGSSnFGVGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.10|      47|     878|      95|     141|      11
---------------------------------------------------------------------------
   95-  141 (83.54/50.17)	FHNVTPKSKAFIESWFKDLAGS.KPLMN..LGKRVPIFNKKEE..IFIQLSE
  974- 1025 (69.56/40.50)	FSNAYPKIKQTIFAPVVSLPKSvHPLNRdfLQDYITSPRRKPEphILRQLSD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26827 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EQQIVMDTPDSPKDESHNTLEPGRGEKEGKRQSRHLLF
2) FKMEIPSSDQSPRGVTKRGQKTNQRRPRGRRGAAAAAAAAAAAATVSQPTVGGGYQSPVASGMYPPQPPPQWNNYTAPAPPASQQGTVPTPAAFFPQQTIGPRFPSERPGTQSRQALSNMLRQRHTSTQFVPGSGANPAGANPAAVPSAPPTGAGGGAMPNNPRQQFMRQQMRQQHTGGNVFGQQGPQQAQPQQQQQQQQQQQQQQQQQQQQQQQVQMAPGGFSNIHTPMNQNFGMFQSGTPGMQQLVNPQQQQAQSQPAQQQPQQQGMMGQHFPQGAGNFPMQQTQPQGNMILMQQQHQQPQGRGMNATPMRPPFMQSAGMQMNAAQPNQFVRGAMPNQQQAVRLQHQQMVAIQQQQQMQHNMGQQQQHNQHYHQPF
3) MENRPLKKLRLGPPDVYPQDPKQKEDELTPVNVKQGFSHTPNLNQSEEYGSAK
681
1788
1
718
2165
53










Molecular Recognition Features






MoRF SequenceStartStop




1) AAAAAAA
2) MENRPLKKLRLGPPDVY
1822
1
1828
17