Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MTSQKSTREVLLTCIDDIEIIAKELLDNLIAQKQQKPMSTEHSQLVELVLQKDTDLKATLKLAEEQGVLQQKVVALETEVERHDVEIRNLQKQLKEAEQLLATAIFQAKQKLQSITRANNRPVNSEELIKFAHRISASNAVCAPLNWQQGDLRRPYPTDIEMRLGFLGRLGEMNVNGHMSFPELLHRPNHSLQQGSSVPNSQAGTYSWLSQNDLQMPCLSVSHLGVSGGMDHKNPKKENEDVDVMSTDSSSSSSSDSQ |
Length | 258 |
Position | Middle |
Organism | Daphnia pulex (Water flea) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Crustacea> Branchiopoda> Diplostraca> Cladocera> Anomopoda> Daphniidae> Daphnia. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.564 |
Instability index | 60.25 |
Isoelectric point | 5.64 |
Molecular weight | 28836.23 |
Publications | PubMed=21292972 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP26814 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 98.94| 30| 32| 124| 155| 1 --------------------------------------------------------------------------- 124- 155 (44.60/40.02) NSEELIKFAHRISASNaVCAPLNWQQgDLRRP 159- 188 (54.34/37.75) DIEMRLGFLGRLGEMN.VNGHMSFPE.LLHRP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 52.62| 18| 36| 55| 72| 2 --------------------------------------------------------------------------- 55- 72 (28.56/17.34) DLKATLKLAEE...QGVLQQK 89- 109 (24.06/13.69) NLQKQLKEAEQllaTAIFQAK --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AGTYSWLS 2) PKKENEDVDVMSTDS | 203 235 | 210 249 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab