Description | Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MSAPLENLENQLELFVENIRQVKIIVSDFQPQGQSVLNQKINSIVQGLQEIDKLKSQVQDVHVPLEVFEYIDEGRNPQLYTKDCMEKALNKNEQVKGKIDSYRKFRAHLLEELSQVFPNETMKYRTSRGDDVNRIP |
Length | 136 |
Position | Middle |
Organism | Daphnia pulex (Water flea) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Crustacea> Branchiopoda> Diplostraca> Cladocera> Anomopoda> Daphniidae> Daphnia. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.678 |
Instability index | 35.37 |
Isoelectric point | 5.45 |
Molecular weight | 15846.82 |
Publications | PubMed=21292972 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364146 |
GO - Cellular Component | chromatin GO:0000785 IBA:GO_Central mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central |
GO - Biological Process | positive regulation of transcription by RNA polymerase II GO:0045944 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP26807 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) KIDSYRKFRA 2) KYRTSR | 98 123 | 107 128 |
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