<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26793

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMDKYIDSRFERLEKALSNLIDSVTKYHPSTIQAEELKAADNELSKGLEEVQIHQNNHLRIQKLRQSSAALDTQIRDTLTSLANTHKDIVSTHTTTYPSEPNYPIAYEELLRYARRISKTTLPPAATLEGAAASPETQSPNPESLAQSALTPSARTPSQPQSPAVNGTPQLTAEQPTQPPAANLNTSLPEGMSQYLNPLSGQLFFPWPLEDKIRSGSLASYQVLVEQGIDPKGYDPATEEERRLKEEEERRAKEEQEKAEREAREKQLREERERARAERERQREKEQAEWRRASIVSGQPDGPGLSRAGTALGEKKQFQFTNLDDLDDDDDDD
Length332
PositionMiddle
OrganismMetarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium anisopliae (strain ARSEF 23))
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium.
Aromaticity0.05
Grand average of hydropathy-1.048
Instability index59.39
Isoelectric point4.97
Molecular weight37357.60
Publications
PubMed=21253567
PubMed=25368161

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364141
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26793
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.00|      14|      15|     248|     261|       1
---------------------------------------------------------------------------
  248-  261 (23.55/12.64)	ERRAKEEQE..KAERE
  264-  279 (19.45/ 9.19)	EKQLREEREraRAERE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     104.15|      16|      16|     150|     165|       2
---------------------------------------------------------------------------
   91-  106 (28.86/14.43)	TH..TTTYPSEPNYPIAY
  122-  137 (23.03/10.08)	PP..AATLEGAAASPETQ
  150-  165 (29.65/15.02)	TP..SARTPSQPQSPAVN
  167-  182 (22.61/ 9.77)	TPqlTAEQPTQP..PAAN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26793 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DTQIRDTLTSLANTHKDIVSTHTTTYPSEPNYPI
2) LASYQVLVEQGIDPKGYDPATEEERRLKEEEERRAKEEQEKAEREAREKQLREERERARAERERQREKEQAEWRRASIVSGQPDGPGLSRAGTALGEKKQFQFTNLDDLDDDDDDD
3) TLPPAATLEGAAASPETQSPNPESLAQSALTPSARTPSQPQSPAVNGTPQLTAEQPTQPPAANLNTSLPEGMSQYLN
71
217
120
104
332
196










Molecular Recognition Features






MoRF SequenceStartStop




1) KEQAEWRRASIVSGQP
2) PGLSRAGTALGEKKQFQFTNLDDLDDDD
284
302
299
329