<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26792

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDQLTGSGPERALRDSIKHWTNFVDRCIFKRLDTERFEEFIPLVQNQHPLPPFVIALLFLQPQPYNVITLDPRIPPYIQILTKLGYVDAPSILRVLYKFSSLHTQLKTSQNETQPASKGNNPYQGLKEKGKNPQRWNSSAWVEEFMFYHVIKIIVEGTAFRESRVVLELVQVISKWMELFTSVSSVFATDVMGELQSSQARIDMETARAAFVPLLLRLVEVPALVKAISSPHAKAIRKSLANSMAGFIQTLQPAPGFVERLEIFRTETLARLDPIDKKDQAATNAAMDELLGTTVGLDSFVIPDLLISNTRSAVYVFLNASLVGRPLIDDNVLISYLQNRYQGATQSSAIELIVASFDILANAVFRNEGPKDAHLLKSFLVNKVPLLLCLLFLREPTFDTNASEFCITEALSQVDTSVFPTASLMFDESRSNNPYTESVREEFCTACALHGLVQREHVERILGELSMSYEPSLEKYSKEKLVQDCLADAEKVQGLIRELEKMDGNVGAVCQALVEVMRQLCNNKETMSLKLLCSQLAQKPQILDILLLFEKLPSILDPLCQLLDNWRYEEDQGEYQPIYEEFGSILLLVLAFAYRYNLTAADIGITSPDSCIAKILGRAHISRDGDELTEQEKGHLSGWIHGLFADSGGLGDDLMSSCPPQDFYLLVASLFQNIVVAYTYGYLSDETLKGGIEYLVDTFLLPSLVPALRFLADYLWVEQKEQKAIIKILQLILLPSSISGEASTMLSSVRNLVAKPLEHSLRTYQRQDPKNQDIQPLLRALKDSLPLSRRTGGADHNELQSWTNSSSAGLAGALRHTVQGLVQWSMHPSVNSMPTSYTHRQLIAAQKIMGAKRTLRLLLEEVRTQSETGSANIVYDAVAAIVCAPNVTNEPPPNNQMMDASGNVPPAVQRPLTLREVLRLEAEGCNKLQKADPVLADIVVRLYRRVEAHMVMPQNQAILEAPGIQLDLGSGAGGLGDVDAMAAVGVGADGMTVDGLDMGIGGPGSAGGLDATSDGDLFGGLDTNGMDMFGWGDSMDLSGN
Length1040
PositionTail
OrganismMetarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium anisopliae (strain ARSEF 23))
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium.
Aromaticity0.07
Grand average of hydropathy-0.046
Instability index40.99
Isoelectric point5.06
Molecular weight114766.27
Publications
PubMed=21253567
PubMed=25368161

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26792
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     189.69|      62|     169|      31|     116|       1
---------------------------------------------------------------------------
   31-   95 (101.34/59.23)	RLD..TERfEEFIPLVQNQHPLPPFVIALLflQPQPYNV.ITLDPRIPPYIQILTKL.GYVDAPSILRV
  201-  266 (88.35/40.95)	RIDmeTAR.AAFVPLLLRLVEVPALVKAIS..SPHAKAIrKSLANSMAGFIQTLQPApGFVERLEIFRT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.66|      27|      29|     973|    1001|       2
---------------------------------------------------------------------------
  973- 1000 (46.37/29.81)	GGLGDVDAMAAvGVGADGMTVDGLDM.GI
 1004- 1031 (47.29/27.56)	GSAGGLDATSD.GDLFGGLDTNGMDMfGW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.72|      31|      32|     662|     693|       3
---------------------------------------------------------------------------
  662-  693 (46.64/31.36)	DFYLLvASLFQNIVVAYTYGYLSDETLKGGIE
  697-  727 (51.08/30.50)	DTFLL.PSLVPALRFLADYLWVEQKEQKAIIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.38|      27|      29|     549|     577|       4
---------------------------------------------------------------------------
  549-  577 (47.54/34.18)	FEKLPSILdpLCQLLDNWRYE...EDQGEYQP
  579-  608 (42.84/23.98)	YEEFGSIL..LLVLAFAYRYNltaADIGITSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.50|      17|      35|     395|     411|       5
---------------------------------------------------------------------------
  395-  411 (30.60/19.39)	EPTFDTNASEFCITEAL
  433-  449 (31.90/20.50)	NPYTESVREEFCTACAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.75|      25|      30|     756|     782|       6
---------------------------------------------------------------------------
  756-  782 (39.98/33.78)	PLehSLRT.....YQRQDPKNQDIQPLLRALK
  786-  815 (37.76/24.32)	PL..SRRTggadhNELQSWTNSSSAGLAGALR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.80|      37|     321|     492|     532|      11
---------------------------------------------------------------------------
  492-  532 (53.01/40.49)	VQGLIRelEKMDGNVGAVCQALVEvmRQLCNNKETM....SLKLL
  818-  858 (59.79/34.25)	VQGLVQ..WSMHPSVNSMPTSYTH..RQLIAAQKIMgakrTLRLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26792 with Med5 domain of Kingdom Fungi
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