<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26787

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLILDNSMQVDLDNVDDLFGDDVPLSIPVRPQGKQLQQRLDELRNRGACQAVAWSKSGTIASLAPDGLTLELRFLRCHPDTGAWELSEPTTCDLVKGTPAIPLVHLEWGTTNTPDLAVIDAAGRVALVSFAISLNHPFITRKWETDTIDDLHGIAGCYWLPVAPTNQQKPFNVMYGPANKSGNGYQYESSFVHAIGPNHPHSAKSALFCVSSGGMLKMYWSQNNGRMEETTMELESINTSDELVTHAAFASDKKHLLAAVATSSRQLKLLKIEIQWGGPGSSSEKITMPQNARLNPALVETHIASASWLYAGPNETNYDASMAELSFLHVLPAVMDNTGSSTVPPLIMTVRSRNVGDGSFQSAQSVLDRWEAIESKQSLDSAFEQLGNRRNSVSSDLPNTIKLKKLESIVINKVVIGIQDIQYRKVLLLTMSDGSIEYRDRFTFEEIYANEDLTKVMTLRQVGWTFSDSGPCHQVAFSPTCCSMIQIGDDAKVRWNKLEYPLGDIGSSPQDPHYPATIAALSIAAASCLWHQSNCDDLLAVVQHLATRKRFLPDWISEIIRILKIQVDYSEETHHDSLMRNSPLQSCLSIMSSLGFRGETRRRSFQSKFAIISLNMRNVVILITLASNTPMNIREKMSPLDEHEVVEALAGCAKWSVDLLCWLVDCLFELMNDDNFIQRLNPQRFGELNQYLHDRNDVSLHLLLSSSSRSFVSAVCRRISLLENISNKAIEFYKRQASGDQQGGAKPPNPQLQQAYQKMQQVTSTSLIKVTEFEKLLNILASDIRQTYAQCIPGMARNRPNPPQGKQMDIAIKNTQAHFEMAMLLSGSLGSYFLPVLSKLFAKDLPAFRKLTDPAKLFFADFELLGVQDDRSSLAARKAKGVHVDIFKRTELRSGCGTSRWRRCTRCTAVMEDVFGSRPGFTFVLAQQRKCSCSGYWALLPKGKLVL
Length948
PositionTail
OrganismMetarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium anisopliae (strain ARSEF 23))
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium.
Aromaticity0.08
Grand average of hydropathy-0.211
Instability index50.20
Isoelectric point6.89
Molecular weight105574.55
Publications
PubMed=21253567
PubMed=25368161

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26787
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     202.12|      60|      60|      79|     138|       1
---------------------------------------------------------------------------
   79-  131 (82.63/51.90)	.............................HPDTGA....WELS....EPTTCDLVKGTPAIPLV.HLEWGTTNTPDLAVIDAAGR.VALVSF
  195-  273 (65.75/39.76)	AIGPNHP.............hsaksalfcVSSGGMlkmyWSQNngrmEETTMELESINTSDELVtHAAFASDKKHLLAAVATSSRqLKLLKI
  274-  340 (53.73/31.12)	EIQWGGPgsssekitmpqnarlnpalvetHIASAS....WLYA....GPNETNYDASMAELSFL.HV......LP..AVMDNTG........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.24|      27|      53|     734|     761|       2
---------------------------------------------------------------------------
  734-  760 (49.85/32.02)	YKRQASGDQQGGAKPPN.PQLQ......QAYQKM
  789-  822 (42.39/21.56)	YAQCIPGMARNRPNPPQgKQMDiaikntQAHFEM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.10|      39|      53|     548|     586|       3
---------------------------------------------------------------------------
  548-  586 (67.60/45.54)	TRKRFLPDWISEI...IRILKIQVDYSEETHHDSLMRNSPLQ
  601-  642 (59.50/39.24)	TRRRSFQSKFAIIslnMRNVVILITLASNTPMNIREKMSPLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.59|      32|     130|       2|      36|       7
---------------------------------------------------------------------------
    2-   36 (52.66/46.06)	PLIldnSMQVDLDNVDDLFGDDVPLSIPVRPQGKQ
  138-  169 (62.93/45.72)	PFI...TRKWETDTIDDLHGIAGCYWLPVAPTNQQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26787 with Med16 domain of Kingdom Fungi
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