<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26786

Description RNA polymerase II mediator complex component Srb8
SequenceMGVQPRQPQRGLGSTLHVQRPSNHHQRSISSSQQQYLPTSPVRRDASAALDSSAEPAEAMSGRHVSTPRRQGSKLRLELSNELISAGPISATESPQTLTPSRMMPLPDPMETDNMSPALSRVSQQDSDNPPMPMPRRRLPQTSQAIPSTRPAAPTPASTKKDARPKPYTVEVPTAAPRYVNTNRHETIGRDPFSKGLFSGNADFFPWSGNHHEDEWSTEAIQKGTWDRGSQNEASSARIAIFPALKQRSGLNALSTLFMGVLNQRRIRGQITAPSTFKPPPRVTLTDTKREIWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKDVPTERAVWLAKCVGANEIRAFKRKGASGAFVLGGELKWIRDWTVFVEQFIESVVSAFGEPDWKSKVTYAIRLATCLYSEQLLDRDHYLEWIISGLENSPQSRIPMWILIGQIYWNDLLQSRKCGRRLVFALLKHLNTIENDPDRDILIQLSSQLSTLVIYLLKTNPESFVCPPAWQRLGETLRLVMPTEDAAAQAAYNTVKLRNIRLLVANTTSPPSGRQYLVQLLDSTLQGKCDPGLSARCWASADDKAGILRTAVEWATSLHRPGLAKVYVVAGLIKSWGAHRINATSTILDALGDIPLGDQMRKRLIIRLVGELVRSGHFSVAQYMQWLIGRGGLHGAEEIDPVEGPCPSRLLVELPIHCLLEEQKAQRGSLLRRAGHYSVGDEANDISSALQYVDSSLGLATYLNGSGPFRRPLSLKKLSRKVRNSSWAVQSAIGAHLYDVITSLPPHRPDFVMTLSMFSSVRTMMETVEDYSMLSGILRACSSGPDVDTLAACVDTIDAQLDIFMAIGTAETLFDIFIERLKAMSRDQGIVVRSLLASLASLAARLPQREDLAKQLSQELAQNDRSNAIDACSPVSDSMATQAQTAEGEVSEQIDKLLASGNVIDHPTMNRLFRYVIIKLESGWGKLDDSRRVFSSLLSRLRMLDALHFDKLMADWISHIRTLKERPPLPELFPLLVSFGCLSMSTILHTANAGSVALDITPDTVTSKTATYLQELLQLIIMKLPATALLDAEETYRFQIYQQRAKFEHAKGLLALIRNSLVEYSALQIPGRTAKLPLDDVACQNCLLETMRFMVVADSAIVAEVLNMSTLPPGATSLAHRIVTRLLLPEADSDHHPSFDHILSLADELTMPFCQLKLNLDLSVNLPSISAIEGETPSRFEAFAKAMDKAIESQNIIWTRMLPCLSDDITQSLNTEAHTRFLDLMPSSKSESLASDTTDENRIRLAENLLGVIEAIISGQPPSRSASLTNNLVDKLSDMWEIVTSRDEDRAMAKKEVLGHWLPTLLRFITLHSICSEPAHIATAGPGSSAKTAATPNHEVRARIILLLCGLLLEMETLPKELAGSLAQQIFDIAILLVDALPDDLRTQCAKSILFLPGTTASAGTTSDPRLYYLFSTPRPTSAENLKLVHRDKSSVPYTAAARGMGAMYGIGPTLNERLSPFVLRRWEILSEPTPNVGENDTSLSLRLFEAIKIQ
Length1528
PositionKinase
OrganismMetarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium anisopliae (strain ARSEF 23))
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium.
Aromaticity0.06
Grand average of hydropathy-0.173
Instability index46.59
Isoelectric point7.80
Molecular weight168849.77
Publications
PubMed=21253567
PubMed=25368161

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26786
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.24|      51|     144|     130|     181|       1
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   68-  121 (80.08/43.07)	PRRQGSKLRLELSNELI.SAGPisATESPQTlTPSRMMPLPDPMETDNMSPALSR
  130-  181 (87.16/52.06)	PPMPMPRRRLPQTSQAIpSTRP..AAPTPAS.TKKDARPKPYTVEVPTAAPRYVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.03|      49|     441|     821|     944|       2
---------------------------------------------------------------------------
  865-  915 (75.78/109.91)	VRSLLASLasLAARLPQREDLAKQLSQELAQNDRSNAIDACSPVSDSMATQ
 1373- 1421 (80.25/16.92)	VRARIILL..LCGLLLEMETLPKELAGSLAQQIFDIAILLVDALPDDLRTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     396.89|     125|     145|     943|    1074|       3
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  387-  427 (25.36/ 6.33)	...........EPDWkSKVT.YAIRLATCLYSE.QLLDRDHY....LEW.....I..ISGLENSP............................................................................
  943- 1074 (196.04/124.06)	NRLFRYVIIKLESGW.GKLD.DSRRVFSSLLSRLRMLDALHFdkLMADW.....ISHIRTLKERPP.LPELFPLLVSFGCLSMSTILHTANAGSVaLDITPDTvtskTATYLQELLQL.IIMKLPATALLDAEETYRFQIY
 1092- 1216 (175.49/96.33)	NSLVEYSALQIPGRT.AKLPlDDVACQNCLLETMRFM.......VVADSaivaeVLNMSTL...PPgATSLAHRIVTRLLLPEADSDHHPSFDHI.LSLADEL....TMPFCQLKLNLdLSVNLPSISAIEGETPSRFEAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.45|      44|     184|       6|      49|       4
---------------------------------------------------------------------------
    6-   49 (78.28/45.05)	RQP.QRGL..GSTLHVQRPSNHHQRSISS.SQQQYLPTSPVRRDASAA
  190-  237 (69.17/38.95)	RDPfSKGLfsGNADFFPWSGNHHEDEWSTeAIQKGTWDRGSQNEASSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.81|      51|     135|     544|     597|       7
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  544-  597 (86.14/63.40)	PSGRQYLVQL.LDSTL.QGKCDPG.LSARC.WASADDKAGILRTAVEWA.TSLhrpGLA
  678-  733 (66.67/40.33)	PCPSRLLVELpIHCLLeEQKAQRGsLLRRAgHYSVGDEANDISSALQYVdSSL...GLA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26786 with Med12 domain of Kingdom Fungi
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