<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26780

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMESSGHNGTRTDHDRDSSMNGVNGANGTPQDSGFSKEKASAATATDGSAKAINGNDESRSQESNQNGEAERVISRMNDLPDEIVHITQGFVPLSLLLTRLAQTSHNALQDKVAEMAKMPLPAAAANGSSSYSSSGPDDSSADNLRKKGALTNFAQEWHGKWLKALVIAEWSRKAHLVSKLIDLKFHIDQQRILYDTALDEMVNVKRDLTFARMPSPDLKTALQVLSTGNAPWMPDLGYIEPPTLTPEVQLKWINELNTLLSLRLNLDDFDKIPYHFRNYEISSGRVTFKVEGEFEVDLTIADEDFEKQFWFIDFRYAFTPAASSISESLRNYLENCVNDVLGKEGLLGCYQFLHELVLTTKIHELKRQAMQLSRTSWTGTLNVEPLNRALSIQYWTGRSTTTGSKSWIIVAVNSNRSINGKEAASSTSQLVVNWYRDNKEVKDVEIEFNANELSAEALLTNVIARHIEHILTSIHDKLLTVARFKNHEASMALRVSRTDPAFSSLTTQVGHSGEASMLLEPMTGVFALKPPSRFTIQPEHQLNMGKNPAEDGLNCLEVLRCAVMEDELHCRATLMGWFVRKPPMAAEELKSAIKVRDWTRVICLQKDGWGSNWFVVVVLSLNGDEWWLLESNPNEASKTLRFKAKLPFNNGHPDLSDVFWENLAFFTTGVIAQSVDLRELHRQKIKSRSSNRISLSTSQTVRLPSTDVALSALFPSMVFDQSKPEEDALSNSEGQLSNLELLSLIQQASGAVLVRKKAWADNIVSITFRGIRCLSKAENADDGSKENELICTSEAILKVRKPSKFASLDGLADRDVSYNPKRGEFALRIQRAVGRPILDTLKSRIKAIDRFVNFLEALESANGTITTESVTLRQITFYYSELQTKQSSNDADQVMEDSRKRWRVVLDLSKDDIDIEIEKGNPHLRVLDLMRQLVNSDGGIGVLTAWLPASLPALQAIDKMETEWEPIQAAGQGRIEFSMKTVAWMSVEYTMTSDAKTLKNPIRLQVQMQPRRSQAWWHVWRSDAEPNADDRVSTALQPIWNKRGDNWFGLSTGAAGRPQDGVVKMLLAVDEAIRSTITSGPGVTQGNEVVVLD
Length1093
PositionTail
OrganismMetarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium anisopliae (strain ARSEF 23))
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium.
Aromaticity0.07
Grand average of hydropathy-0.365
Instability index39.06
Isoelectric point5.80
Molecular weight122051.62
Publications
PubMed=21253567
PubMed=25368161

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26780
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.12|      25|      29|     993|    1017|       1
---------------------------------------------------------------------------
  631-  660 (34.29/16.23)	SNPNEASKTLRFKAKLpfnngHP...DLSDVFW
  993- 1017 (44.20/22.81)	SDAKTLKNPIRLQVQM.....QP...RRSQAWW
 1022- 1048 (36.64/17.79)	SDAEPNADD.RVSTAL.....QPiwnKRGDNWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.65|      22|      29|      16|      37|       2
---------------------------------------------------------------------------
   16-   37 (42.12/29.75)	DSSMNGVNGAN.GTPQDSGFSKE
   46-   68 (32.53/21.11)	DGSAKAINGNDeSRSQESNQNGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.79|      16|      29|      77|      92|       4
---------------------------------------------------------------------------
   77-   92 (28.56/22.91)	NDLPDEIVHITQGFVP
  106-  121 (27.23/21.46)	NALQDKVAEMAKMPLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.65|      21|      27|     794|     814|       6
---------------------------------------------------------------------------
  794-  814 (33.49/21.53)	EAILKVRKPSKFASLDGLADR
  824-  844 (34.16/22.11)	EFALRIQRAVGRPILDTLKSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.09|      10|      29|     500|     511|       7
---------------------------------------------------------------------------
  500-  511 (14.15/17.04)	PafSSLTTQVGH
  531-  540 (19.94/14.04)	P..SRFTIQPEH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.56|      23|      31|     548|     577|       8
---------------------------------------------------------------------------
  548-  577 (34.58/35.74)	PAEDGlnclEVLRCAV.MED..ELHCratLM..GW
  582-  609 (28.98/14.53)	PPMAA....EELKSAIkVRDwtRVIC...LQkdGW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.40|       9|      33|     267|     276|       9
---------------------------------------------------------------------------
  267-  276 (15.10/11.52)	DDFDKiPYHF
  303-  311 (19.31/10.00)	EDFEK.QFWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.73|      17|      27|     376|     392|      10
---------------------------------------------------------------------------
  359-  379 (22.13/10.89)	TTKIHELKRQamqLSRtSWTG
  380-  397 (27.60/15.30)	TLNVEPLNRA...LSIqYWTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.16|      16|     205|     403|     422|      11
---------------------------------------------------------------------------
  403-  422 (20.50/22.75)	GSkSWIIVAVnsnRSINGKE
  610-  625 (30.66/17.56)	GS.NWFVVVV...LSLNGDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.20|      10|      17|     458|     469|      13
---------------------------------------------------------------------------
  458-  469 (13.77/13.59)	LLTnvIARHIEH
  478-  487 (18.43/10.35)	LLT..VARFKNH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26780 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MESSGHNGTRTDHDRDSSMNGVNGANGTPQDSGFSKEKASAATATDGSAKAINGNDESRSQESNQNGEAERVISRMND
1
78










Molecular Recognition Features






MoRF SequenceStartStop




1) FSKEKASAA
34
42