<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26778

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMAQLIGSSGPERALRDSMEYWSRFVDKCIFKRLNTETFEEFIPLVQDQHPLPPFLIALLFLRPQPHNVVSLDPRIPPYIQILSKLGYVDAPSILKVLYKFSSLHTQLKPSLQNETQSASKDNNLDQGSKEKSKNPRRWNSSAWVEEFMFYHVIKIIVEGTALRDSRVVLELVQVISKWMELFTSVSNVFATDVMGELQNSQARIDMETTRAAFVPLLLRLVEVPALVKAISSPHAKAFRKSLSNNLAGFIQTLQPAPGFVERLEIFRTETLARLDPIDKKDQAAANAAMDELLGTTVGLDSFVIPDLLISNTRSAVYVFLNASGATQSSAIELIVASFDILANAVFRNEGPKDAHLLKSFLVNKVPLLLCLLFLREPTFDTNASEFCITEALSQVDTSVFPTASLMFDESRSNNPYTESVREEFCTACALHGLVQREHVERILGELSMSYEPSLEKYSKEKLVQDCLADAEKVQGLIRELEKMDGNVGAVCQALVEVMRQLCNNKETMSLKLLCSQLAQKPHILDILLLFEKLPSILDPLCQLLDNWRYEEDQGEYQPIYEEFGSILLLVLAFAYRYNLTAADIGITSPDSCVAKILGRAHISRDRDELTEQEKGHLSGWIHGLFADSGGLGDDLMSSCPPQDFYLLVASLFQNIVVAYTYGYLSDETLKGGVEYLVDTFLLPSLVPALRFLADYLWVEQKEQKAIIKILQLILLPSSISGEASTMLSSVRNLVAKPLEHSLRTYQRQDPKNQDIEPLLRALKDSLPLSRRTGGADHNELESWTNSSSTGLAGALRHTVQGLVQWSMHPSVNSMPTSYTHRQLIAAQKITGAKRTLRLLLEEVRTQSETGSANIVYDVVAAIVCAPNVTNEPPPNNQMMDASGNVLPAIQRPLTLREVLRLEAEGCNKLQKADPVLAEIVVRLYRRVEAHMVMPQSQTILEAPGIQLDLGSGAGGLGDVDAMAAVGVGGDGMTVDGLDMGIGGPGSAGGLDATSDGDLFGGLDTNGMDMFGWGDSMDLSGN
Length1021
PositionTail
OrganismMetarhizium acridum (strain CQMa 102)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium.
Aromaticity0.07
Grand average of hydropathy-0.050
Instability index43.40
Isoelectric point5.05
Molecular weight112650.77
Publications
PubMed=21253567

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26778
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.50|      17|      36|     376|     392|       1
---------------------------------------------------------------------------
  376-  392 (30.60/22.80)	EPTFDTNASEFCITEAL
  414-  430 (31.90/24.10)	NPYTESVREEFCTACAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.68|      14|      27|     535|     550|       2
---------------------------------------------------------------------------
  535-  550 (22.87/18.47)	SILdpLCQLLDNWRYE
  565-  578 (23.81/11.86)	SIL..LLVLAFAYRYN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     239.17|      80|     324|     590|     674|       3
---------------------------------------------------------------------------
  439-  488 (35.29/10.64)	VERILGELSMSYEpslekyskeklvQDCLADAEK..VQGLIRELEKMDGNVG..............................................
  593-  674 (137.65/81.28)	VAKILGRAHISRD............RDELTEQEKghLSGWIHGLFADSGGLGD.DLMSSCPPQDFYLLVASLFQNIVVAYTYGYL...SDETLKGGVE
  949- 1003 (66.23/30.10)	...........................................LGSGAGGLGDvDAMAAVGVGGDGMTVDGLDMGIGGPGSAGGLdatSDGDLFGGLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.22|      16|     154|     348|     373|       5
---------------------------------------------------------------------------
   43-   60 (28.07/ 8.02)	PlvQDQHPLP.......PFLIALLF
  351-  373 (24.15/16.97)	P..KDAHLLKsflvnkvPLLLCLLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.02|      27|      34|     141|     170|       6
---------------------------------------------------------------------------
  141-  170 (38.63/38.86)	SAWVEefMFYHVIKII...VEGtALRDS..RVVLE
  176-  207 (39.39/26.63)	SKWME..LFTSVSNVFatdVMG.ELQNSqaRIDME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.58|      52|      55|     809|     863|       7
---------------------------------------------------------------------------
  809-  863 (71.17/57.26)	PSVNSMPTSyTHRQLIAAQKITGA.KRTLrLLLEEVRTQSEtGSANI..VYDVVAAIV
  866-  920 (81.41/50.77)	PNVTNEPPP.NNQMMDASGNVLPAiQRPL.TLREVLRLEAE.GCNKLqkADPVLAEIV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26778 with Med5 domain of Kingdom Fungi
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