<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26775

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMESSGHNGTRTDHDRDSSMNGVNGANGTPQNPGFPKEKASAATAADGSAKAINGNDESRPQESNQNREAEGVISRMNDLPDEIVHITQGFVPLSLLLTRLAQASHNALQDKIAEMAKMPLPAAAANGSSSYSSSGPDDSSADNLRKKGALTNFAQEWHGKWLKALVIAEWSRKAHLVSKLIDLKFHIDQQRILYDAALDEMVNVKRDLTFARMPSPDLKTALQVLSTGKAPWMPDLGYIEPPTLTPEVQLKWINELNTLLSLRLNLDDFDKIPYHFRNYEIGSGRVTFKVEGEFEVDLTIADEDFEKQFWFIDFRYAFTPAASSIPESLRNYLENCVNDVLGKEGLLGCYQFLHELVLTTKIHELKRQAMHLSRTSWTGTLNVEPLNRALSIQYWTGRSTTMGSKSWIIVAVNSNRSRNGKEAASSTSQLVVKWYRDNKEVKDVEIEFNVNELSAEALLTNVIARHIDLILTSIHDKLLTVARFKNHEASMALRISRTDPAFSSLTTQVGHSGEASMLLEPMTGVFALKPPSRFTIQPEHQLNMGKNPAEDGLNCLEVLRCAIMEDELHCRATLMGWFVRKPPLAAEELKSAIKVRDWTRVICLQKDGWGSNWFVVVVLSLNGDEWWLLESNPNGASKPLRFQAKLPFNNGYPDLSDVFWENLAFFTTGVIAQSVDLRELHRQKIKSRSSNKISLSVSQTVRLPSTDVALSALFPSMVFDQSKPEEDTLSKSEGQLDNLDLLSLIRQASGAVLVRKKAWADNIVSITFRGIRCLSKPENADDGTKENELICTSEAILKVRKPSKFASLDGLADRDVSYNPKRGEFALRIQRAVGRPILDTLKSRIKAIDRFVNFLEALESANGTITTESVTLRQITFYYRELKTKQTSDDEDQVMEDSPKRWRVVLDLSKDDIDIEIEKGNPHLRVLDLMRQLVNSDGGIGVLTAWLPASLPALQAIDEMETEWEPIQAAGQGRIEFSMKTVAWMSVEYTITSDPKTLKKPIRLEVQMQPRRSQAWWHVWRSDAEPNAEDGVSTALQPIWNKRGENWLGLSTGAAGRPQDGVVNMLLAVDEAIRSTVTSGPGVTQGNEVVVLD
Length1093
PositionTail
OrganismMetarhizium acridum (strain CQMa 102)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium.
Aromaticity0.07
Grand average of hydropathy-0.357
Instability index37.60
Isoelectric point5.77
Molecular weight122115.12
Publications
PubMed=21253567

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26775
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.78|      28|      29|    1008|    1036|       1
---------------------------------------------------------------------------
 1008- 1036 (46.87/30.72)	MQPRRSQAWWHVwRSDAEPNAEDGVSTAL
 1039- 1066 (50.92/27.87)	IWNKRGENWLGL.STGAAGRPQDGVVNML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.32|      22|      29|      16|      37|       2
---------------------------------------------------------------------------
   16-   37 (41.71/24.24)	DSSMNGVNGAN.GTPQNPGFPKE
   46-   68 (32.61/17.42)	DGSAKAINGNDeSRPQESNQNRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.65|      15|      27|      77|      93|       3
---------------------------------------------------------------------------
   77-   93 (21.44/22.73)	NDLPDEIVHITQgfVPL
  106-  120 (25.21/17.30)	NALQDKIAEMAK..MPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.51|      24|      31|     550|     577|       4
---------------------------------------------------------------------------
  550-  577 (38.55/45.22)	EDGLNClEVLRCAI.MED..ELHCratLM..GW
  581-  609 (29.96/20.87)	KPPLAA.EELKSAIkVRDwtRVIC...LQkdGW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.40|       9|      33|     267|     276|       5
---------------------------------------------------------------------------
  267-  276 (15.10/14.85)	DDFDKiPYHF
  303-  311 (19.31/12.90)	EDFEK.QFWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     256.00|      89|     205|     403|     505|      11
---------------------------------------------------------------------------
  403-  505 (122.83/124.67)	GSkSWIIVAVnsnRSRNGKE.........AASSTSQLVVKWYRDN..KEVKDVEIEfNVnelsaeALL.TNVIARHIDLilTSIHDKLLTvARFKNH...EASMALRISRTDPAFSSL
  610-  713 (133.17/92.14)	GS.NWFVVVV...LSLNGDEwwllesnpnGASKPLRFQAKLPFNNgyPDLSDVFWE.NL......AFFtTGVIAQSVDL..RELHRQKIK.SRSSNKislSVSQTVRLPSTDVALSAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26775 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MESSGHNGTRTDHDRDSSMNGVNGANGTPQNPGFPKEKASAATAADGSAKAINGNDESRPQESNQNREAEGVISRMND
1
78










Molecular Recognition Features






MoRF SequenceStartStop




1) PGFPKEKASAATAAD
32
46