<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26769

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDAAEYDTNVLVVNNIASISFRVYEPSSDQSPSFGLAAIDIENSLREKGHIVYYDASRRGIWHFRIVGKEGSDEVSSQELDSSLSLRGYSLIVGEEGSFEPSSLPRPRSQQPQTGHTPTSSTSSAPALDQSQRYAPTATPHLGPPGLQEQDSKGHTSVTDAKLVQGGSSSPKAYESFVVATLLTIQSAFCRHTDSIPLNYRTVLLSQDILGNDGSLDVITEKIPTIGTFGAYLTTTGVLVVCMGISLCQGLLSYGDMLNQAPDVPGQQILAAPFGVIASNQPAAQLDGGTASMAQTPNTQALSLRGAPDIHNSLWKQACLKFLHLRGVAQSKLTDCFWMNILISKPKLQDAKSDIKRSPMPNSTVTIPWPSPLCFRKRPVEVSSTSRVGETILRGHEESHDPLGNAQFWFSSTPERDEKISKRKAERVATSSEGFSGDSRPTRLNGQSPLTLRRPSTAAAGSMYPTPPDALQNANGVTPSLDGTLSSPGNPLSAAAVPEGDNNGSVSMAMGESFEPVRDFSEPKRQRSDSNLLGEADHMFGDMGEDMFGDNDITEADFNFFDEEPEDIDLEAALDEMDDATTAATIGAEEHTADEEISNAREPIKEEPQSEKDAGGFTKPELRHAISVQNDNAMPRGREIRPVSMKRESSPFDPHTVFKRVCASLAATEKDGAFTTDTSRMTKIFEKMDFDPTLPMINKKYEQGGQFDYSKSTTAGNSRLDHGVLPETDYLKRHGKLHRGLKEHKLYARSLMGPLSGLEPPTSGRSPTKLDTQMSDDEQSSTESDQDDSSYTSDEPTSPPKSSVKQAPVEDDAVSQVTSLKEQDVTEEPDYQLAVELPRLSKPETPELPLSMLFSDPEPLPLELSLSDEDLIQAAQILTEQAATGSLDLCNTDYPSNTSIVSQGRATLLSDARTALQQLREALSVFLRGVEPVRLKAFLDIQDVLLQGQPRMQPRPIPGRDTNAEQIRPSNLYQIPGPHLEVRRSDAKLSVLPSAVAFWESLGLAPSSGNKDITAVCVFPGWKGMTDNAKTFLGRIKSVYEVLRLGSFENMALASDMDSGVLPYEMDRISTSPDAALTGHGSALIGAMETLRGSLSNLTVSDTNIVVYFVYSPNNPGTIVEACAAFQHFFDSYQKDLAAKKETATNELVLQLVSSELLSSPTSVVVTPSVDLVRLCIETYDRCTLFGGPMPAPAIRLEQPLPRIIDFKLNTQPSVSLIRENSCIHVAYAQTVDGRWVTTAWTDDRGNQQATASYCLGRKGRPLSTSMSEVAHEIWQSTLDLISAWKVHWRIIITKCGPMDQQEIDSWVNLAHAETRLQVTMILMTVDTDPWLQLVPPVVKLPQASVPFYTTPVSTPQANIVSPEQSATPATPANVTAATPGGGEAGADTETDAILADVTDQTWGAIVGHRLNNSLGVTDLYPALVSGFLIKRTGARAEDVPMAMQVNLIHTDAFPRSYEPLLREMLSYFRGLATLSRARGMVSRETDVRPWHIAAAEKAARAMYLLM
Length1507
PositionKinase
OrganismMetarhizium acridum (strain CQMa 102)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium.
Aromaticity0.06
Grand average of hydropathy-0.361
Instability index50.41
Isoelectric point4.94
Molecular weight164000.19
Publications
PubMed=21253567

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26769
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.74|      17|      18|     531|     547|       2
---------------------------------------------------------------------------
  531-  547 (32.82/20.70)	NLLGEAD.HMFGDMGEDM
  551-  568 (26.92/15.64)	NDITEADfNFFDEEPEDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.36|      15|      18|     280|     295|       4
---------------------------------------------------------------------------
  259-  273 (26.39/15.74)	NQ.APDVPGQQILAAP
  280-  295 (20.97/16.84)	NQpAAQLDGGTASMAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.62|      13|      19|    1338|    1352|      10
---------------------------------------------------------------------------
 1338- 1352 (18.26/16.46)	VVKLPQASVPfyTTP
 1360- 1372 (23.36/12.37)	IVSPEQSATP..ATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.46|      14|      19|     698|     711|      11
---------------------------------------------------------------------------
  698-  711 (26.25/18.48)	NKKYEQG..GQFDYSK
  717-  732 (21.21/13.24)	NSRLDHGvlPETDYLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.31|      16|     320|     429|     452|      15
---------------------------------------------------------------------------
  429-  444 (26.90/ 6.86)	ATSSEGFSGDSRPTRL
  456-  471 (26.41/20.41)	STAAAGSMYPTPPDAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.95|      39|     316|     629|     674|      17
---------------------------------------------------------------------------
  629-  674 (54.35/54.61)	QNDNAmprgREIRPVSMKResSPfDPHTVFKRVCASLAATEKDGAF
  960-  998 (67.60/42.52)	RDTNA....EQIRPSNLYQ..IP.GPHLEVRRSDAKLSVLPSAVAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.80|      14|      21|    1040|    1053|      19
---------------------------------------------------------------------------
 1040- 1053 (24.17/16.14)	YEVLRLGSFENMAL
 1064- 1077 (24.63/16.61)	YEMDRISTSPDAAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26769 with Med13 domain of Kingdom Fungi
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