<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26762

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMGVQPRQPQRGLGSTLHVQRPPNHHQRSISSSSQQQYLPTSPVRRDASAALDSSAEPAETMSGRHVSTPRRQGSKLRLELSNELISAGPISATESPQTLTPSRLMPLSDPMETDNMSPALSRVSQQDSDNPPMPMPRRRLPQTSQAIPSTRPAAPTPASTKKDVRPKPYTVEVPAAAPRYVNTSRHETRSRDPFSKGLFSGSADFFPWSGNHHEDEWSTEAIQKGTWDRGSQNEASSARLAIFPALKQRSGLNALSTLFMGVLNQRRIRGQITAPSTFKPPPRVTLTDTKREIWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKDVPTERAVWLAKCVGANEIRAFKRKGASGAFVLGGELKWIRDWTVFVEQFIESVVSAFGEPDWKSKVTYAQLSTLVISLLKTNPESFVCPPAWQRLGETLRLVLPAEDAAAQAAYNNVKLRNTRLLVANTASPSSGRQYLVQLLDSTLQGKCDSGLSARCWASADDKAGILRTAVEWATSLHRPGLAKVYVVAGLMKSWGAHRINATSTILDALGDIPPGDNIRKRLIIRLVGELVRSGHFSVAQYMQWLIGRGGLHGAEEIDPVDGPCPSRLLVELPIHCLPEEQMAQRGSLLRRAGHYSVGDEANDISSALQYVDSSLGLATYLNGSGPFRRPLSLKKLSRRIRNSSWAVQSAIGAHLYYVITSLLPHRPDFVMTLAMFSSIRTMMETVEDYSMLSGILKACSTGPDVDTLAACVDTIDAQLDIFMAIGTAESLFDVFIERLKAMSRDQGIVVRSLLASLASLAARLPQREDLAKQLSQELAQNDRSNAIDACSPVSDSMATQAQTAEGEVSEQIDKLLASGNVIDHPTMNRLFRYVIIKLESGWGKLDDSRRVFSSLLSRLRMLDALHFDKLMADWVSHIRTLKARPPLPELFPLLVCFGCLSMSTILHTANAGSVALDTTPDIVTSKTATYLQELLQLIIMKLPATAVLDAEETYRFQIYQQRAKFEHAKGFLALIRNSLVEYSAIQMPGRTALLPLDNTACQDSLLETMRFMVVADSAIVAEVLNMSTLPPGATSLAHRIVTRLLLPEANSDHHPSFDHILSLADELTMPFCQLKLNLNLSVNLPSTSDMEGEKPSRFEAFAKAMDKAIESQNIIWTRMLPCLGDDITQSLNTEAHTRFLNLMPSSKSESLANDTTDEKRIRLAENLLGVIEAIISGQPPSRSASLTNNLVDKLSDMWEIVTSQDGDRAMAKKEVLEHWLPTLLRFIALHSISSESANIATAGPGSSAKTAATPNHEVRARIILVLCGLLLEMETLPKELTGSLAQQIFDVAILLVDALPDDLRTQCAKSILFLPGTTASTGTTSDPRLYYLFSTPRPTSAENLKLVHRDKSSVPYTAAARGMGAMYGIGPTLNERLSPFVLRRWEILSEPTPNVGENDTSLSLRLFEAIRIQ
Length1446
PositionKinase
OrganismMetarhizium acridum (strain CQMa 102)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium.
Aromaticity0.06
Grand average of hydropathy-0.184
Instability index46.93
Isoelectric point8.48
Molecular weight158983.24
Publications
PubMed=21253567

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26762
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     360.95|     119|     145|     861|    1001|       1
---------------------------------------------------------------------------
  861-  992 (181.35/170.13)	NRLFRYVIIKLESGWGKLD.DSRRVFSSLLSRLRMLdalhfdkLMAD..WVSHIRTLKARPP.LPELFPLLVcfgclSmSTILHTANAG.SVALDTTPDIVTSKTATYLQELLQL.IIMKLPATAVLDAEETYRFQIY
 1010- 1134 (179.60/117.55)	NSLVEYSAIQMPGRTALLPlDNTACQDSLLETMRFM.......VVADsaIVAEVLNMSTLPPgATSLAHRIV.....T.RLLLPEANSDhHPSFDHILSLADELTMPFCQLKLNLnLSVNLPSTSDMEGEKPSRFEAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     482.01|     124|     145|     244|     367|       2
---------------------------------------------------------------------------
  118-  204 (105.40/69.91)	..........................................................PALSRVSQQDS.DNP..PMP.MPRRRLpQTSQAIPSTR.PAAP..TPASTKKDVR.PKPytVEVPA....AAPR..YV...N.TSRHETRSRDPFSKGLFSGSAD
  213-  332 (183.92/129.33)	HEDEWS.TEAIQKGTwDRGSQNEASSARLAI..........................fPALKQRSGLNALSTL..FMGVLNQRRI.RGQITAPSTF.KPPPRVTLTDTKREIW.LKD..LANPA....ISLR..RL...SRTIPHGIRGRTLLDQCLNKDVPT
  333-  478 (142.83/98.24)	ERAVWL.AKCVGANE.IRAFKRKGASGAFVLGGELKWirdwtvfveqfiesvvsafgePDWKSKVTYAQLSTL..VISLLK.........TNPESFvCPPAWQRLGETLRLVLpAED..AAAQAaynnVKLRntRLlvaNTASPSS..GRQYLVQLLDSTLQG
  479-  537 (49.86/27.88)	KCDSGLsARCWASAD.DKA....G.....ILRTAVEW.....................ATSLHRPGLAKVYVVagLMKSWGAHRI.NATST........................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     200.97|      65|    1212|      35|     102|       4
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   35-  102 (99.74/76.21)	QQYLPTSpVRRDASAALDS.SAEPAETMSGRHVSTPRRQGSKLRLELSneLISAGPISATES.PQTLTPS
 1250- 1316 (101.23/65.94)	EHWLPTL.LRFIALHSISSeSANIATAGPGSSAKTAATPNHEVRARII..LVLCGLLLEMETlPKELTGS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26762 with Med12 domain of Kingdom Fungi
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