<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26754

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSNSFTLPLRPARQKANREDDLAVKIAQINAQKGSFRDVTEASLLAEIEAARAVGDGEAEAVDVKRGEDEEENREEKLFKSRLEISQFAMNAHMEATYALEFVSLLLSKHTPRQAETSMSPLLKQKVPLGSLGADHIKPPEQSETQKRDVDAVSRGWKLESFDAAANKLLQSAQRLEEDIAAETKYWSEVLKIKEKGWKVCRLPRERQTLGVHFGFLESTQNFRDRGLAALRKGEAGRLILDRGIQLKPPRFVRVRVQRGDQTLGLTMPAISKQLDDQCLDGRIREARDSLYEEELFYELNREARVLLQHGVEIRRDLIKFPADDNKQIFVDLVELDEALPEIGGLEPLDNLLAEGVAKSFRILLSYAHRKNHHRRTRVPPPVTPNKRPAPEYNIIRPLLCYFQHRSHYQWFTSFFGTLSKTLRSAGLKCSYTLCPLMKRPQSRAGSSRQTLTVSSVERLIDTLINPSESIISCNLISQGSVFRVRITTNVNPNGLGSEFELVTNLAHFPAQQSPFRFGLREDVRDLIIHLFTLDLVYLVPSLVKGSASAGASETLISRYTGSQAFVEEESTDENEFAPSPAAKQDDVYLLPWQPTFPQQGELTAYSPARCRTKKLQIQLQSDQLQLRCFWVRHRGPSTKADEQPGERLFTWRAVDMLGEAEESSRPTLQRVMELLGEKYDDQTVQNIGSK
Length691
PositionHead
OrganismCoccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Coccidioides.
Aromaticity0.07
Grand average of hydropathy-0.503
Instability index52.82
Isoelectric point7.22
Molecular weight78293.98
Publications
PubMed=20516208

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26754
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.89|      41|      51|     205|     255|       1
---------------------------------------------------------------------------
  205-  248 (61.13/70.20)	RERQTLGVHFGFLesTQNFRDRGLAAlRKGEAG................RLILDRGIQLK
  259-  315 (60.76/38.84)	RGDQTLGLTMPAI..SKQLDDQCLDG.RIREARdslyeeelfyelnreaRVLLQHGVEIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.76|      45|      57|     579|     624|       2
---------------------------------------------------------------------------
  579-  624 (76.94/38.38)	PSPAA.KQDDVYLLPWQpTFPQQGELTAYS.PARCRTKKLQIQLQSDQ
  637-  683 (69.81/31.00)	PSTKAdEQPGERLFTWR.AVDMLGEAEESSrPTLQRVMELLGEKYDDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.55|      16|      51|     360|     389|       3
---------------------------------------------------------------------------
  360-  375 (29.11/42.34)	SFRILLSYAHRKNHHR
  395-  410 (31.45/11.21)	IIRPLLCYFQHRSHYQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26754 with Med17 domain of Kingdom Fungi
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