<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26752

Description Uncharacterized protein
SequenceMASLNTPECPVMSSRPSMSCGNSSSSGLAIQGHSQRPSQTDPSAVEQAAHDSVIDLTNSDYETCDANRATKRQKLDLRIDVPNTQRVPKAQFSQAVSTPFALQDTVPPIRTGRPFWDFGEEVSGFGFQGSLESEIPNDEPEQPDSLPPLPVRPWRYGPQGHSSREETPRVNQNAGAEVQTTPFCIEVPEAAPTFNSGKPLDFYPWKGGHPEDSLTDQTAKQGYYDRVQVSQNESNTARPSLYVQLKHRSGLKLLSSVFTAAIDKRQSHCRVTGFSTFKPPPRVTLTDIKRETWLRDLANPSVPLRRLSRTIPHGIRGRILLDQCVNKAIPIGRAVWLVKCVGANEIRAFKRKGTSAAITHSLEVKWVRDWSINVQQFIESVVTACGTPNWASTMSYVIRFAARLFQEQLLDQALCLDWFLQSLRTAPIGTLPIWLSMLGAYWTSLVRYRKRGRPLAESLLEKLKTILSLEDSGPKKQIADRLSWLIKTFAESHPACFVLPLTWRTYKSTLTTCFCLHLSEDNRKMGALSNRNERIVKAEICRQSGRQSPSQRVICLLDSTDSLNDMEILSSGCLNLDFDHGNLIMKILEWVSTSFRRGSARVYVAVRLLRKWRRSGMDTDNCIVNFLQQKADTPGFSPANIYHLVCELVRSQSFAVGKYLQWLMARGAVRNDAPMHPTVQLLAHLPRRKLPSHVWNLRNTLLTKAGFLLSSENQQTLNTKRYIHHRLPEVIIKPIAGDHEGLFSPSDLSNLNWTIKSEIGHWIREHVSLHRKRYLRTAPNHHNACAIEISALTPAQFFEIRDIIECLGDLSLLADILKHTSSSDNIIVLISVVDTLNYCAGSFKAIGALSDLFKSALAGYAHVNKADVSIIELISSLLEVGMKLPGEIPVVAMLRRDLSHFDKKFTGAVSSPVSDHTAESVNIASPAFSEGLHQLLNSGSGMDEPNMNKIFEMLSRKLKQSKEPNASSHEIARHLSQLRVLNSDVFDRLMVKWIISTLKSSPRPHLLTFLPPLIGVGCVTFEAFFALIDRLLKSDSHRQSIQDVSGLRYEMINLLRKEIFYELGSVDLVSYRFKITREEYITHHAYDALGLVNEALADVNPESTSHPPLVPLLCELIIQNLNAFGPEGAGRIVEEFPNCVDIIHQALDVLLGLKAQAGVQKTQSVVGLIDDLSLSYCLVKLRLLLDANPDGDAARSSIVDLLFRTAESDIRNGERRWLEVLNVLPVSAAHLIRQRAEREILSLSLISSSLTTFSSEEDALIYLCIVEELSYSIPDEFSPSSMGADLGDKMFLLLQKTVELANAKKGTDLESGASSTALGVAELSIGVWFFVLLRLVALHRSLVPPNCDSRTEINHQTRLLVQICCISRSPLFARRSTQSFISSISTFTKCDSLLRMLPSSWANLQLQALDVCSTLVDTLSDEARYECARFLRDKCPAFLHPQNDARLLFLFGPSIESQSITTHGSSRASTSTPVTNLTQHVQSTPPPSQNTPTPGMVEEPNLFTNKLRFQQNGRITGPYPPKPWEILGDAAPIIGINDTPVNLAYFGTRQSKRL
Length1554
PositionKinase
OrganismCoccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Coccidioides.
Aromaticity0.07
Grand average of hydropathy-0.179
Instability index50.77
Isoelectric point8.37
Molecular weight173263.33
Publications
PubMed=20516208

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
ECO:0000256
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP26752
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     222.95|      46|      49|     134|     179|       1
---------------------------------------------------------------------------
   31-  102 (32.58/13.34)	QGHSQRpsQTDPSaVEQAA.....hdsvidltnsdyetcdanratkrqkldlriDVPNTQR.VPKAQFSQAVSTP..FAL
  103-  158 (72.58/38.69)	QDTVPP..IRTGR.PFWDFGEEVS....................gfgfqgslesEIPNDEP.EQPDSLPPLPVRPWRYGP
  159-  209 (73.03/38.97)	QGHSSR..EETPR.VNQNAGAEVQ........................ttpfciEVPEAAP..TFNSGKPLDFYPWKGGH
  210-  244 (44.77/21.07)	PEDSLT..DQTAK...QGYYDRVQ.....................................vSQNESNTA...RPSLYVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     357.98|     114|     205|    1137|    1255|       2
---------------------------------------------------------------------------
 1137- 1255 (176.87/130.34)	PNC...VDIIHQA.LDVLLGLKAQAGVQKTQSVVGLIDDLS.LSYCLVKLRLLLDANPDGDAARSSIVDLLFRTAESDIRNGERRWLEvlNVLPvsaAHLIRQRAEREILSL..SLISSSLTTFSS
 1345- 1465 (181.11/120.75)	PNCdsrTEINHQTrLLVQICCISRSPLFARRSTQSFISSIStFTKCDSLLRMLPSSWANLQLQALDVCSTLVDTLSDEARYECARFLR..DKCP...AFLHPQNDARLLFLFgpSIESQSITTHGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.46|      45|      49|     390|     435|       3
---------------------------------------------------------------------------
  390-  435 (77.48/59.12)	WASTM.......SYViRFAARLFQE...QLLDQALCLDWFLQSLRTAP.....................IGTLPIWL
  442-  485 (61.79/41.52)	WTSLV.......RY..RKRGRPLAE...SLLEK...LKTILSLEDSGP..................kkqIADRLSWL
  590-  663 (51.19/32.93)	WVSTSfrrgsarVYV...AVRLLRKwrrSGMDTDNCIVNFLQQKADTPgfspaniyhlvcelvrsqsfaVGKYLQWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.15|      31|      51|     691|     723|       4
---------------------------------------------------------------------------
  691-  723 (49.88/35.58)	PSHVWNLRNTLLTKAGFLLssENQQTLNTKRYI
  745-  775 (57.27/35.08)	PSDLSNLNWTIKSEIGHWI..REHVSLHRKRYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.85|      33|     222|     787|     838|       5
---------------------------------------------------------------------------
  787-  830 (35.49/72.95)	IEISALTpaqffEIRDIIEclgdlSLLADiLKHTSSSD.NIIVLI
  841-  874 (49.37/29.72)	GSFKAIG.....ALSDLFK.....SALAG.YAHVNKADvSIIELI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26752 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CGNSSSSGLAIQGHSQRPSQTDPSAVEQAAHDSVIDLTNSDYETCDANRATKRQKLDLRIDVPNTQRVPKAQFSQAVSTPFALQDTVPPIRTGRPF
2) GFQGSLESEIPNDEPEQPDSLPPLPVRPWRYGPQGHSSREETPRVNQNAGAEVQTTP
3) TTHGSSRASTSTPVTNLTQHVQSTPPPSQNTPTPGMVEEPNLFT
20
126
1461
115
182
1504










Molecular Recognition Features






MoRF SequenceStartStop




1) VRPWRY
151
156