<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26749

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGLAMDGPSAMASRATVADIHYDPASASQQANGGIYPNGIGKKSHSPVDGLHDSHIGCLHELPPELSHITLGFFPFNNLISRVVQQSWNDLNELLNEMGSTQAYQTGISSQLSATKNGMSEKFRGDQATENSLKKLRILEFTHSRRAEFIKLLVLSQWSRHANEVSRLIDIQAFIRMRSGFYEGALFHIGNMKQNLIVAQLANPDLKTASHVLSAGKIDALHGLEFLSPRPLAPSQVLRLLRGINKLIDMRLALHDHVPDSLQNYFVHDGRVTFIVPNEFEIDLSVASASPSAQFFLVDMKFLFFPSSLPKGRLRSIVDHQVNSTLMNAGLVGCFNLLHNLILTHKITILFKQAIDLARTYWSEHLRVELFHRTLVLQYWSKKPGGKSWIEIGVHSGLKGSPQSTGTTTSFLQLRWFRDNEEVSATDIDFNLTFLSAKSILFSAISLHITHILRTAFEALRQNRLYCLGGLYIGMSASSKEPGDCYLELQMTQTSHLDIMVEAVSGDTVLRVTPSPITRYDTEIIVDRGSVEDIVERVSRLRCVSALEEVERYAKAVGWMPLNLRHVNLESLKRIFPPSALRSMLLFRAKCWEPSWLAVFTSAMDGDNWWIVQLQTQNPPALQSHWRLLEAQRAKVITGWFTGWLGRLHNASFSSLLSALSGMIMVQCNVDFLNEIGAIHFFPPPKDLLLQPCLRVPSIYLRLRHDDFPSQFRTIFSGGSPRRSFIDETFRISFKGIDQQSGHAITMVYGRLMTDIDMFGALYAKSVRDIAFQPKGRGFAILFRTPVGTPIITPLLERLQQMNNIAFVVESMKSQGFQPHSLSPSRINFSYPTQGELRGSIKFSYHDQGSHFESKLLFPATTTKPILHPRIGIDFNYQNPHRRITESLSAILNSHKDGMSLVLELINITLPLLVTLERICAEEYIDNAWYFQAQYTARSARLYQIRYPFLRYRFNVSASQRKSYVVWVIQNSTPGPERSKHPSLELRLKDQIYNSQGDGWRGINQGAMAYSANVSRLVFDLHQLMKSYISQMAKSNQRGEPTDSSPSAGCEFGRYLPKNENEKGHIQTTTAPTLEHAYGNSNVVVQSVRQGEAAARDVDVIAID
Length1105
PositionTail
OrganismCoccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Coccidioides.
Aromaticity0.09
Grand average of hydropathy-0.169
Instability index46.19
Isoelectric point9.03
Molecular weight124492.09
Publications
PubMed=20516208

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26749
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.34|      63|      74|     398|     468|       1
---------------------------------------------------------------------------
  398-  468 (92.63/80.67)	GLKGSPQSTGttTSFLQLRWfrdnEEVSATDIdfNLTFLSAKSIL...FSAISLHITHIL..RTAFEAL..RQNRLYC
  475-  544 (95.71/60.73)	GMSASSKEPG..DCYLELQM....TQTSHLDI..MVEAVSGDTVLrvtPSPITRYDTEIIvdRGSVEDIveRVSRLRC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.49|      44|      76|     773|     848|       2
---------------------------------------------------------------------------
  777-  821 (73.80/46.46)	GRGFA..ILFRTPVGTPIITPLLE.RLQQMNNIAFVVESMkSQGFQPH
  850-  896 (69.69/75.20)	GSHFEskLLFPATTTKPILHPRIGiDFNYQNPHRRITESL.SAILNSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     197.96|      66|      78|     166|     240|       3
---------------------------------------------------------------------------
  166-  240 (99.58/91.54)	VSRLIDiqafirMRSGFYE...GAL..FHIGNMKQNLIVAQLANPDLKTASHVLSAGKIdaLHGLEFL.SPRPLaPSQVLR
  245-  316 (98.38/66.87)	INKLID......MRLALHDhvpDSLqnYFVHDGRVTFIVPNEFEIDLSVASASPSAQFF..LVDMKFLfFPSSL.PKGRLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.49|      13|      17|     351|     365|       4
---------------------------------------------------------------------------
  351-  365 (20.01/19.18)	LFKQAIDLarTYWSE
  371-  383 (25.47/16.59)	LFHRTLVL..QYWSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     152.36|      44|      78|     548|     592|       5
---------------------------------------------------------------------------
  548-  588 (64.72/27.67)	.......................................LEE..VERYAKAV.GWMPLNLRHVNLES.LKRIFPPSALRSMLL...F
  590-  666 (38.71/15.46)	AKCwepswlavftsamdgdnwwivqlqtqnppalqshwrLLE..AQR.AKVItGWFTGWLGRLHNAS.FSSLL..SALSGMIM....
  667-  731 (48.92/17.36)	VQC....................nvdflneigaihffppPKDllLQPCLR.V.PSIYLRLRHDDFPSqFRTIFSGGSPRRSFIdetF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.91|      15|     597|      49|      65|       6
---------------------------------------------------------------------------
   49-   65 (26.52/22.44)	VDGLHDshIGCLHELPP
  671-  685 (30.39/18.19)	VDFLNE..IGAIHFFPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26749 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MAKSNQRGEPTDSSPSAGCEFGRYLPKNENEKGHIQTTTAPTLEHAYGNSN
1033
1083










Molecular Recognition Features






MoRF SequenceStartStop




NANANA