<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26746

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFPAGAVTNFRMTLPSPGAGVLEGPSSALAIELESAILLIRDQGCLVDAIPGGNGVWVFSHNGEFDQLQPFSVLESDCSLTTLQIGAITFKQFHAEFTPLGYLIKRLMAEPQGTIFSPLSQQKFANTNEDCPINREIVTSSAFYKAFTSAIAGSLSLRATQLHGAIPLGKRALFTTSAPDEKLGQGINADPTLGPRSLLSTLNIEFSFKSLIISWRTIPQWGLQQLSTIAGADSISDVSLHEDIWLAPTGSLCRYIGADPGHSSGPQWDPSVGDYGEFEYPGGGNLLHLREWKRAVCVRLRMFGLGSVDPDTETWIEVEALNPFESRLGGTAGENRKSIAYKRFLWPARLCFKRSSEQCLALDKRAEYLDAATLDPLSLAEKWVTEMTTRTSPEDQMAVETHVAEGMQPEATGTTEKTSSSEIFASLARKFDFSDLSAGAVYPTPPGAVTATGLVAAGSSDILTLPGGSSLSHAHPQNTSRRSDVNISGAGCQSTSNSLPPVDITTTALEIGSGMYDTTADDDLFDELDGDFAPKQITEADFNFFDEPDFTAFPGSIDVSMGRVDTSLQNSHGAHDRDALDIAGTSHDAVERPAGSAEPEERKDSMRNREHRVVLVPPAVSSPKENVQADLPIESRNIISPTPATPHQPLSPSIIRKILFSGHSGIPTTTSFDKHPTNRKARSGYEPLSFGEELSLSDGKYELDGRFWFLPNAESDQMEMHPSDIPRVGIPEWRNEERRALPMEDSSRDRLKSGMQSSSDSSAEPSEDDSEPETTPLDYSNRGLRVLSASRDNSQRFKDLDFTPSPLEPLTVNTEFSNTGMDANTLSFLRTLLFRAIDWTLDGYFTSTSGRFPVLLRRDDLIQVAQIVVDQVTQSSLSHVLERRTSIGLDQQNALPLSSTSKDSWYGKFSNFDIKRYTAIDVDTSIQGLRKDFRYLTVGSMSKLDPPHIRIHRGKGELEVLPPAIFFWEPFGFEPTQGQKDILAYCIYPESAEEGADAFLARMGLLYSSANLGQHSRPQDSKGLIPWGLECTSIHDYTAIMNRLQTTCEHLGDVISCLPPGSENILVYIANPFPYEAAVVDICTAFLFLFRKYVSNFEKHTIRLNEVALQIIPLDFIASLTSLVVPSQQDYLHLAFEVYSRCPPKSRSSDLLGCAPPFTLAKPAPKIVPFKLTPDSGSPLAEKHSIHVAYSQSIDQRWVTAAWTDNLGRDQLTMTYCLRERGSTISRPASEIRADIWSVTRHIIGKSHTYWRVMVVKDEPLELDEAEAWVSMAQHHNQTKPTKIELTLLSVNPKPCLFFKLPPPPLQPSTLTGPTTSTPVSTPNPSMPSPDPSAAAPTPPPSSAEQAQTPIAQSLDPADSETILIDKTEETWSITLSHRVNISPSLANYHPALASGYLLRRRDGTSDTEGLASLCVNLIFTHSRIPSEMVLKDTLRVYRDLVTLARTKGIFHAQGDDVLPWHISTAVKGREFLGVVL
Length1478
PositionKinase
OrganismCoccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Coccidioides.
Aromaticity0.08
Grand average of hydropathy-0.293
Instability index45.97
Isoelectric point5.15
Molecular weight162293.69
Publications
PubMed=20516208

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26746
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.07|      17|     136|    1152|    1180|       1
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 1164- 1180 (33.08/37.29)	PAPKIVPFKLT.PDSGSP
 1303- 1320 (29.99/ 7.85)	PPPPLQPSTLTgPTTSTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     514.08|     136|     143|     668|     810|       2
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  528-  636 (126.51/66.64)	.....................................ELD.......GDFAPKQITEADFNFFDEPDftaFPgSIDVSMGRV..D..TSLQNSHGAHDRDALDIAGTSHD.AVERPAGSAEPEER.KDSMRNREHRVVlvppavSSPKENVQ..ADL......PIES
  668-  809 (220.62/139.11)	PTT..TSFDKHPTNRkarsgyEPLSFGEELSLSDGKYELD.......GRFWFLPNAESDQMEMHPSD...IP.RVGIPEWRN..EERRALPMEDSSRDRLKSGMQSSSDS.SAEPSEDDSEPETT.PLDYSNRGLRVL......SASRDNSQrFKDLDF.TPSPLE.
  810-  947 (166.95/92.39)	PLTvnTEFSNTGMDA......NTLSFLRTLLFRAIDWTLDgyftstsGRFPVLLR.RDDLIQVAQIV...VD.QVTQSSLSHvlERRTSIGLDQQNALPLSS...TSKDSwYGKFSNFDIKRYTAiDVDTSIQGLR...........KD....FRYLTVgSMSKLDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     160.08|      42|      65|     276|     317|       3
---------------------------------------------------------------------------
  241-  269 (29.86/13.93)	............LHEDI........WLAPTGS............LCRYIG...ADPGH..SSgpqW.
  276-  317 (77.41/49.50)	YGEFEYPGGGNLLHLRE........WKRAVCV............RLRMFGLGSVDPDT..ET...WI
  322-  385 (52.81/31.10)	LNPFESRLGGTAGENRKsiaykrflWPARLCFkrsseqclaldkRAEYLDAATLDPLSlaEK...WV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.31|      42|      77|      73|     121|       5
---------------------------------------------------------------------------
   73-  120 (56.40/65.91)	SVLESDCSLTTlQIgaITFKQFHAEFTP..LGYLIKRlMAEPQGTIfsPL
  126-  169 (67.91/45.59)	ANTNEDCPINR.EI..VTSSAFYKAFTSaiAGSLSLR.ATQLHGAI..PL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.75|      24|      82|    1051|    1074|       6
---------------------------------------------------------------------------
 1051- 1074 (46.57/30.11)	HLG.DVISCLPPGSENI.LVYIANPF
 1134- 1159 (39.18/23.97)	HLAfEVYSRCPPKSRSSdLLGCAPPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.38|      18|      22|     460|     477|       7
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  460-  477 (33.00/20.72)	S..SDI.LTLPGGSSLSHAHP
  481-  501 (23.38/12.20)	SrrSDVnISGAGCQSTSNSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.21|      10|     893|     436|     447|       9
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  436-  447 (16.97/16.21)	DLSAGAvyPTPP
 1332- 1341 (22.24/12.63)	DPSAAA..PTPP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26746 with Med13 domain of Kingdom Fungi
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