<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26744
Description |
Mediator of RNA polymerase II transcription subunit 16 |
Sequence | MTALMWTIFLVTPIPWSWALPPLHRPGKVYLKDLTSYGFRDAVAWSKLGAIAYISNDGQKVFLQNILCNADDGEWSLCDGRFRCKIAEAQSGHTFIHLCWHESGSDLAIVDSCGRVMIVSMSIALNAFAVSRSIVIDPDDDGNQPVGLMWLGVNRPVHAFNKASKTNGRWVYSRYVRRPLGPFHPLNKSALVCVTRSGHIRLLYQSQDPKWNEVHVDLQTVSCSDDILTHAALSASQGGSILMVTYSTQHRLFVYRVQIKWDAAPVDTTQQQPVGISVAQTPTIQITHIRTEIQRSVFQRADNDYERSPSARVMPILTHLDIVGIASDGSAGSYVEPYILAAFAIPVSALETQRQFNGTSSIVRWALESTGQSTHSSFDEIPPKRQTLNLTPKTELTRWDDVHFDKRVLSIDYFEAGSVVSLTFDDGSISFYDAKTMNAISDNEDLATISITCISFSPNGCLAVTLDEDSELHLHVMEHSFGIEHGMYNDEQFGAAVAALALAFSHACSNDSSSDDVMMIAARSLTPDTRKTFITEVYHALSVNADFTIEQDKLMNNPYIQKCFSMQAALGFNGQLEQRNLAAAIPWFTLQLRQISILFAYFLHFNKSGSDSECHEPDILRMVLGNVRWALDLAKYLIDDLFEIASSFDKHSGDQSDKKLESFSMLLVLSSIPRAFLKYICRGLRGIPSSFRSATNLSTESFGVYSNIVRLIEESPLRVDVYEKFLLSIDNVIKYTYQNAGFGSTDRSIPERDLLITASVPPVLQPAVVTILTNTMTLIRPDVDLLHLCTWDYSWLGIDDDKLTRLFRRRNEVDILKKTITQLGEPQAKSKQPKRRCARCCAVSEDATSPKSLASFRLLVKTVVLRTCICGGLWMVENLDTISRGPVSAWK |
Length | 891 |
Position | Tail |
Organism | Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Coccidioides.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.072 |
Instability index | 44.69 |
Isoelectric point | 6.07 |
Molecular weight | 99556.41 |
Publications | PubMed=20516208
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364149
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | |
GO - Biological Process | |
Interaction
Repeat regions
Repeats |
>MDP26744
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 98.82| 40| 135| 153| 198| 1
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153- 170 (12.69/13.81) ........................................VnrPVHAFNKASKTNG.....RW
175- 198 (33.69/15.63) YVRRPLGPFHP.LNKSALVCVTRSG......................................
305- 365 (52.44/26.87) YERSPSARVMPiLTHLDIVGIASDGsagsyvepyilaafaI..PVSALETQRQFNGtssivRW
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 181.46| 42| 42| 622| 663| 2
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585- 617 (47.12/31.81) .....IPWfTLQLRQ..ISILFAYFLHFNK.SG..SDSECHEP
622- 663 (73.88/54.60) MVLGNVRW.ALDLAKYLIDDLFEIASSFDKHSGDQSDKKLESF
667- 702 (60.46/43.17) LVLSSIPR.A..FLKYICRGLRGIPSSF.RSATNLST...ESF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 72.17| 26| 46| 442| 471| 6
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442- 471 (34.71/26.52) DNEDL.ATISITCISFSpNGClavTLDEDSE
489- 515 (37.46/18.27) NDEQFgAAVAALALAFS.HAC...SNDSSSD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 116.15| 35| 125| 114| 148| 7
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114- 148 (60.57/41.50) GRVMIVSMSIALNAFAVSRSIVID..P.DDDGNQPVGL
239- 276 (55.58/37.46) GSILMVTYSTQHRLFVYRVQIKWDaaPvDTTQQQPVGI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 44.39| 12| 688| 95| 106| 8
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95- 106 (27.19/18.25) FIHLC.WHES..GSD
785- 799 (17.21/ 8.71) LLHLCtWDYSwlGID
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