<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26743

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMLRRVSSASVPQSPLLEPQKSQWHHRLPHSTPTAHLDDRAAHVRFPSPFMTATPQSYASSFSTTQSTSPAQSASQSAPDSSSPPSSLAMSAQPAQQLTATNAFPTPASSVSGVAKESQDPSEKAARALMESAEGAPGFTDIDNGILQNQQIPQNQQETIAGLIPQEDAMDIDRKDDLSEDPKIAALQQDIGQAFHTCKSSYSISGPSPRFDLISLYGLGPVAASVARTDPVTGEKINRLRKSYEGKIKGLGLSGRNKAVKREPGAPGGLRQLTMWPEEEWQNQKVIGKDIRVAEPDSTLHKLHMRAMKLEPGPVPNNDYWEDVLGHEKPPKQGASAVQPKKAADTVGGAVRQSTQANGTPISTPAPPVESGRPKRAGKKRSYNDSSFVGYGEGFPDDDLDMDGGFYSNSEEGARGSAKKKRKKDHVPVVPPSLTERKGSYGVGMFGVGTR
Length450
PositionHead
OrganismCoccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Coccidioides.
Aromaticity0.05
Grand average of hydropathy-0.737
Instability index58.82
Isoelectric point8.67
Molecular weight48222.16
Publications
PubMed=20516208

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP26743
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.77|      20|      24|      78|      99|       1
---------------------------------------------------------------------------
   54-   71 (25.19/ 8.73)	......PQSYASSFSTTQSTS.PAQ
   72-   95 (29.85/ 9.15)	SAsqsaPDSSSPPSSLAMSAQ.PAQ
   98-  122 (21.74/ 9.03)	TAtnafPTPASSVSGVAKESQdPSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.15|      22|     127|     134|     161|       2
---------------------------------------------------------------------------
  134-  161 (34.51/34.01)	GAPGftdidnGILQNQQIPQN..QQETIAG
  264-  287 (37.64/22.44)	GAPG......GLRQLTMWPEEewQNQKVIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.50|      11|      15|      24|      34|       3
---------------------------------------------------------------------------
   24-   34 (22.91/15.96)	HHRLPHSTPTA
   42-   52 (21.59/14.54)	HVRFPSPFMTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     133.38|      44|     155|     163|     208|       4
---------------------------------------------------------------------------
  163-  208 (75.05/48.00)	IPQedAMDIDRKDDLSEDPKIAALQQDIGQAFH..TCKSSYSISGPSP
  219-  241 (25.18/ 9.88)	GPV..AASVARTDPVTGE.KINRLRK......................
  338-  366 (33.14/14.56)	.................QPKKAA..DTVGGAVRqsTQANGTPISTPAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26743 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLDMDGGFYSNSEEGARGSAKKKRKKDHVPVVPPSLTERKGSYGVGMFG
2) MLRRVSSASVPQSPLLEPQKSQWHHRLPHSTPTAHLDDRAAHVRFPSPFMTATPQSYASSFSTTQSTSPAQSASQSAPDSSSPPSSLAMSAQPAQQLTATNAFPTPASSVSGVAKESQDPSEKAARALMESAEGAPGFTDIDNGILQNQQIPQNQQETIAGLIPQEDAMDIDRKDDLSEDPKIAA
3) QKVIGKDIRVAEPDSTLHKLHMRAMKLEPGPVPNNDYWEDVLGHEKPPKQGASAVQPKKAADTVGGAVRQSTQANGTPISTPAPPVESGRPKRAGKKRSYNDSSFVGYGEGF
398
1
283
446
185
394










Molecular Recognition Features






MoRF SequenceStartStop




1) DYWEDVLGH
2) FVGYGEGFPDDDLDMDGGFY
3) KKKRKKDHVPVV
4) MLRRVS
318
387
418
1
326
406
429
6