<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26736

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMSEDEAQQLIHKLLLQALARRLPQSRWLSLLHQLARRIDATPDNIEHDEDTPPLAGSNAAGCLVRYILSQSFIDPLLIEYLQALIYGSANRSGITPDQGPVTDVITLTLHLLAHVQAAASNVPAIETISSVIGQGLLMTFQAPVPFRVASPSFLALLQHLFASSALDAKDETPTATAEESSSHTKDSTNAAAAMAFVIANLRLLALAADPTIASPQNLLAPRVAITVLINVGQSLLAHAIQKLSATQTTKDHKLKPDDGLLRQTRSTAKTCVAEIEAVLQSMNPAWKDEIALLRSLTSQIGVIEQISQTLAEATTSKLSTRTPKRKAETLQDAQQRATWDHFLDVSTVAAAQKPPVEPEMALLMHLLVDQHTAWDSKLDAVKTLFLARRNAAAPSLTLEKSLTAFYFELLVAAIDACATVVESPPTFKGAQVYVAIWRHALCGMVPELVLQLEQWLDERQDLPLRGQRLEAPHVRLEGALRAALLVMASRLDTCESATGQSHAQTAAAAAGGGEDAVGVNAGMMTDVLGLDTPPLQPIKAWLLRACIEHSLARPEAIADEFPDGHKLASEVQTLTQSLRMDAQLEGLALNTLFETRVSTDDPIELLHRVASDPGTHYIFARQLVLQMQGWLEQHDLESIARWCKALSEDAAQGGAMLDTVMMYVDPVQLVEPLASVLDQRDVGQTSDEPSTLSNILLFVQLLCYRYSVAPERISRYTVAGDEMELGAASAAQEDSDRSASPPFLATHLAASSVCYPLAALCEEERQLVGRWIHALFGNEGISDDLIQASPPPTLLRLAPLLFSQSVAACQYGIIDLETLRGGLSYFLQDLLSFALPGALVWLLAEIARTPLQPILDFLSDCGLQAAVVDVPSSDGTLANGLPRNASSRTVHLEVLALLLDTDACPPSVREVTAPAFEAFLAVVDAEAGGARLGAGCETFDLVSLKARMEGAGVTAALLSTRGGAWLRTVVQGAAKESGLVRQLAGDSMARIIHAVGRGECAHSRADQKALAAWLCLVAPACPTNAHIPPVLHFVQRLDLTTEHVESAMRVLGLALALVRAAEIARATNASDLLALVHARDTAAHAAAEAGDLFDDEPSTPPLPSALAAAPSGSRGVGAEAAVTPAHVMVRRRFGVTARQVCDVLVAKLVRLRKREAVLAAVRDHVDGAEGEEESEGLAGWLAALQ
Length1185
PositionTail
OrganismSporisorium reilianum (strain SRZ2) (Maize head smut fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Sporisorium.
Aromaticity0.05
Grand average of hydropathy0.124
Instability index50.16
Isoelectric point5.13
Molecular weight126744.52
Publications
PubMed=21148393

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26736
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     587.45|     175|     181|     565|     745|       1
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   72-  164 (73.73/34.63)	............FIDPL.LIEYLQALIygS.ANRSG.ITP..DQGP...VTDVITLTLHLLAHVQAAAsnvPaiETISSVIGQG....LLMTFQA.PVPFRVASPS....FLA.....llqHLFASS.......................................................................................
  565-  650 (92.36/53.08)	.........................................................................................................................HKLASEV.QTLTQSLRMDAQLEGLALN.TLFETRVSTDDPIELLHRVASDPGT.....HYIFARQLVLQMQGWLeqhDLESIARWCKALSEDA
  651-  830 (265.14/156.42)	AQGGAMldtVMMYVDPVQLVEPLASVL..D.QRDVG.QTS..DEPS...TLSNILLFVQLLCYRYSVA...P..ERISRYTVAGDEMELGAASAAQEDSDRSASPP....FLA.......tHLAASSVcYPLAALCEEERQLVGRWIH.ALFGNEGISDDLIQ.....ASPPPTllrlaPLLFSQSVAACQYGII...DLETLRGGLSYFLQDL
  834-  983 (156.22/84.53)	ALPGAL...VWLLAEIAR..TPLQPIL..DfLSDCGlQAAvvDVPSsdgTLAN.....G.L..........P..RNASSRTVHLEVLALLLDTDACPPSVREVTAPafeaFLAvvdaeaggARLGAGC.ETF.DLVSLKARMEGAGVTaALLSTRGGA.....WLRTVVQGAAK.....ESGLVRQL...........................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.98|      17|      17|    1055|    1071|       2
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 1055- 1071 (27.93/15.30)	LALVRAAEIA..RATNASD
 1073- 1091 (24.04/12.10)	LALVHARDTAahAAAEAGD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.27|      20|     207|      29|      71|       3
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   50-   71 (30.70/47.07)	DTPPLAGSNAAgcLVRYILSQS
  531-  550 (39.57/11.34)	DTPPLQPIKAW..LLRACIEHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.78|      52|     603|     389|     478|       4
---------------------------------------------------------------------------
  393-  478 (58.40/110.71)	APSLTLEKSLTAFYfeLLVAaiDACATVVESPPtfkgaqvyvaiwrhalcgmvpelVLQLEQWLDerqdlpLRGQRLEAPhVRLEG
 1001- 1052 (95.38/56.06)	AHSRADQKALAAWL..CLVA..PACPTNAHIPP.......................VLHFVQRLD......LTTEHVESA.MRVLG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.39|      67|      72|     225|     296|       5
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  225-  296 (98.25/83.81)	ITVLINVGQSLLAHAIQKLSaTQTTKDHKLKPDDGllrQTRSTAKTCVaEIEAVLQSMNPAWKDEIALLRSL
  300-  366 (112.14/77.65)	IGVIEQISQTLAEATTSKLS.TRTPKRKAETLQDA...QQRATWDHFL.DVSTVAAAQKPPVEPEMALLMHL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26736 with Med5 domain of Kingdom Fungi
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