<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP26735

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPSPLHGANPTTSHHHVNQNRQSTSSHASRLPSSSPTKPLMTSNGNGNGNGAHFHAASPSAALSPTHVALDKSKQIATSPHKLMMGVPPAATPSLASASNDSSSRQQQPPHDAHHANGHANGSAVVAVDTKGKQKQVDPIDAIPLAQLEQELPLEEADLVSLAALVERLANYGYESLQNLAETLPSLPSSSKRAKIFNTALDVRKQFIKLLVLARWSKDVADLQKSRNIIALLSEQQWQHEDVFAGLTDIRKILPNARMRNADLPTAIDVLQTGTYRRLPSSIKDMAVATKPFTDEQALAIVTRLEEALRTRMACRERVPAPLSSYSIRDGKVHFSVPGLFDAQLTASSGGQDADDDTPTSADDRWWLLDLSFDVAATGSCAESSTRSFPRKPKKAYRERLRVWGDQELAPKSQSAQSEATADEDKSDPLRAAAQTAQDTADEKPADAKESKEIGQPAETTLQDEPATVKASAERDAPLSRLFAFLQERSLHYQMDILQHQAYELCRLNWGANLRVETSERPRRLTLHYWTQAQGADGAAQRADSPAAGGSVRITIVDLPDRAGATKTLAMLLDDDSDPTSKTEERTSPVAVKRRGLQVTWDAHASILADAETSNLVVSPHSLDVESLLSSVIKRHTLALLRNLQRRILVSDHAVSRLLRPEDCTLCVEHAQRQGDEFSTATEATSFSFLQIELRRSSRPRSAINKQGSTSGVPPLRLSVDAVSGRLLLDAETTQSSTTDLHVAQQAANFTASILTTRPTNARLTEASDRINESMEAIFDVLYRLEVFARVEEWERMASYLGLRAVRNLNLRAQDLVKFGPSTSTSPDAAPQLFIPLRNSFPGYFLALQPSELAGATIALVYVVQMMEATGAPTLTVQSIEWLDRAKIAAASNAGSDGEDDAAVLAAAEAGQKRKDAPGGVPGQASEADGSFGKKDLTMEELGDVHSYCIALVSYFRVEQQLRMRGIPYLHVGSNTSRSSPPAKRQRRLPSTRFGPQSADARDEGLFDEEENGADEPADEAHQSASDTGVAALVPSLCLRAADLLGPARSHLTKPNVSLRIRDWDDSDKCCVQMRIKLRMKSRRFRTLHEVVSFAPTSDQHTTSPLTWIDFDNETSLLTLSTRDLDNCIPTFYTQWERVMRMVQLAREVLNVSRAWQQRALRSRVSCKKPAGLVELRRFDFDTVVFSYGSMAVDGTERKLLVRVRWQDAKMEMQPYTNMPVTQSGGYVVEFGSIPTGELESLDSPTALDASASAETAARKHDEAVSKWFGDVHAAANPHNALAFELRRTVNVAARTAAMHAAVHPHAERTVWRGFFKLLQDTLALVREMAPLADKCLSEPDVPEVEVKSATWFRLRFRDRYALDLRLVTRSRLLVSDAARALFRSEGQQGPGQEEEVAGSETADADLFAGSDLLNSLIAGTAPRAHANSAAKAKGAATSHVDPTPAAAALQFQPIPNIDSVLRKVHAALHPPSAAADDDGVHNLRRALLVSLAPATSTALKSEPLLGTLIPLLVELVSREIGG
Length1523
PositionTail
OrganismSporisorium reilianum (strain SRZ2) (Maize head smut fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Sporisorium.
Aromaticity0.05
Grand average of hydropathy-0.377
Instability index49.23
Isoelectric point6.22
Molecular weight166057.73
Publications
PubMed=21148393

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP26735
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     519.27|     172|     226|     164|     361|       1
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  164-  358 (246.46/205.42)	ALVERLANYGYeslQNLAetlPSLPSSSKRAkifnTAlDVRKQfIKLLVLARWSKDVADLQ....KSRNIIALLSEQQWQHEDVFAGLTDIRKIlPNAR....MRNADLPTAIDVLQTGTYR..RLPSSiKDMAVATKPFTDEQALAIVTRLEEAlrTRMACRERVPAPlssysirDGKVHFSVPGLFDAQLTASSGGQDADDDT
  396-  577 (272.80/163.48)	AYRERLRVWGD...QELA...PKSQSAQSEA....TA.DEDKS.DPLRAAAQTAQDTADEKpadaKESKEIGQPAETTLQDEPATVKASAERDA.PLSRlfafLQERSLHYQMDILQHQAYElcRLNWG.ANLRVETSERPRRLTLHYWTQAQGA..DGAAQRADSPAA.......GGSVRITIVDLPDRAGATKTLAMLLDDDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     181.61|      38|     152|     799|     836|       2
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  799-  836 (69.55/35.52)	SYLGLRA.VRNLNLRAQDLVKFGPSTS..TSPDAAPQL..FIP
  954-  990 (52.71/25.18)	SY..FRV.EQQLRMRGIPYLHVGSNTS.rSSPPAKRQR..RLP
 1026- 1056 (31.67/12.26)	SDTGVAAlVPSLCLRAADL..LGPARShlTKPN..........
 1483- 1511 (27.68/ 9.82)	............NLRRALLVSLAPATS..TALKSEPLLgtLIP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     267.45|      82|     164|    1223|    1305|       3
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 1223- 1305 (134.41/89.35)	QSGGYVVEFGSIPTGELEsLDSPTALDASASAETAARKHDEAVSKWFGDVHAAANP.HNALAFELRRTVNVAARTAAMHAAVHP
 1389- 1471 (133.04/84.17)	QGPGQEEEVAGSETADAD.LFAGSDLLNSLIAGTAPRAHANSAAKAKGAATSHVDPtPAAAALQFQPIPNIDSVLRKVHAALHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     314.43|     101|     625|      19|     124|       4
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   19-  124 (158.64/111.02)	QNRQSTSSHA.SRLpsSSPTKPLMTSNgNGNGNGAHFHAASPSAALSPTHVALDKSKQIATSPHKL..MMGVPPAATpSLASASN....DSSSRQQQPPhDAHHANGHANGSA
  645-  752 (155.79/90.44)	QRRILVSDHAvSRL..LRPEDCTLCVE.HAQRQGDEFSTATEATSFSFLQIELRRSSRPRSAINKQgsTSGVPPLRL.SVDAVSGrlllDAETTQSSTT.DLHVAQQAANFTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.51|      19|     552|     579|     605|       5
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  579-  597 (31.45/25.87)	PTSKTEERTSPVAVKRRGL
  620-  638 (31.06/ 9.64)	PHSLDVESLLSSVIKRHTL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP26735 with Med14 domain of Kingdom Fungi
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